Potential detrimental effects of a phytoestrogen-rich diet on male fertility in mice

Cederroth, Christopher R.; Zimmermann, Céline; Bény, Jean‐Louis; Schaad, Olivier; Combepine, Chantal; Descombes, Patrick; Doerge, Daniel R.; Pralong, François P.; Vassalli, Jean‐Dominique; Nef, Serge

doi:10.1016/j.mce.2010.02.011

Cited by 77 publications

(49 citation statements)

References 48 publications

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“…In a recent review of the literature (Cederroth et al, 2010a), we found that out of 32 studies in mice, rats, rabbits, mink, and monkeys concerning the effects of soy or isoflavone exposure (including, gestational, post-natal, and adult chronic exposure), 11 out of 18 of them reported changes (either positive or negative) in the level of reproductive hormones such as testosterone, LH or FSH, but without significant effects on sperm production or litter size. Among the 12 studies that investigated the consequences on sperm production and fertility, only two reported negative effects (Cederroth et al, 2010b;Eustache et al, 2009). It is interesting to note that these two studies were the only ones to assess the effects of life-long exposure (from conception to adulthood).…”

Section: Soy Phytoestrogens and Male Reproductive Functionmentioning

confidence: 99%

Soy, phytoestrogens and their impact on reproductive health

Cederroth

Zimmermann

Nef

2012

Molecular and Cellular Endocrinology

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193

117

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a b s t r a c tThere is growing interest in the potential health threats posed by endocrine-disrupting chemicals (EDCs) to the reproductive system. Soybean is the most important dietary source of isoflavones, an important class of phytoestrogen. While consumption of soy food or phytoestrogen supplements has been frequently associated with beneficial health effects, the potentially adverse effects on development, fertility, and the reproductive and endocrine systems are likely underappreciated. Here we review the available epidemiological, clinical and animal data on the effects of soy and phytoestrogens on the development and function of the male and female reproductive system, and weigh the evidence as to their detrimental impact.

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Section: Soy Phytoestrogens and Male Reproductive Functionmentioning

confidence: 99%

Soy, phytoestrogens and their impact on reproductive health

Cederroth

Zimmermann

Nef

2012

Molecular and Cellular Endocrinology

Self Cite

193

117

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“…Lappé et al (1999), reported that the concentration of soy phytoestrogens is lower in transgenic than in organic soybean. The presence of the soy phytoestrogens, can lead structural and functional modifications in the reproductive tract during development and adulthood (Cardozo & Baó, 2007;Cederroth et al, 2010). In concurrence with a report by Pan et al (2008), consumption of large amounts of soy phytoestrogens can trigger erectile dysfunction, which involves erectile tissue.…”

Section: Introductionmentioning

confidence: 88%

Effects of Transgenic Soybean and Organic Soybean on Rat Penis Morphology during the Aging Process

et al. 2017

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SUMMARY:The contents of soybean can modify the structure of the reproductive system, especially, when consumed for prolonged periods. In this study, we evaluated the effects of the consumption of transgenic soybean on rat penis morphology after prolonged use. Wistar rats (n = 30) were divided into three groups according to diet: Transgenic Soybean (TS) group, Organic Soybean (OS) group and Control (C) group. After 455 days of intake, the rats were sacrificed and the penises were excised and fixed in formalin for subsequent histological processing. The samples were stained with hematoxylin and eosin, Weigert's resorcin-fuchsin stain, and picrosirius red with polarization. The images were scanned for the histomorphometric analyses of the corpora cavernosa, corpus spongiosum, erectile tissue, and tunica albuginea as well as the measurement of the thickness of the tunica albuginea. The diameter and areas of the penile arteries with the intima and media tunica were also measured. The elastic fibers of the tunica albuginea, corpora cavernosa and corpus spongiosum were quantified using stereological methods. No significant differences were observed in the collagen and elastic components among the groups. We concluded that no statistically significant differences were found among the groups, demonstrating that the prolonged consumption of OS and TS does not affect the penile structure.

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“…Several studies suggest that soy-based diets containing phytoestrogens, when consumed in pregnancy and during lactation, can act as key systems hormonal disruptors that control the growth and development, due to the estrogenic activity of these compounds [10][11][12].…”

Section: Soy and Metabolic Programmingmentioning

confidence: 99%

“…Other works point to the toxic effects of phytoestrogens on reproduction and may cause abnormalities in the estrous cycle, and changes in ovarian and testicular function, leading to the development of precocious puberty in female offspring and decreased production of testosterone in male offspring [11,51]. Using organ cultures of fetal testes from wild type and ERα or ERβ knock-out mice, it was shown that genistein inhibits testosterone secretion by fetal Leydig cells during early fetal development [51].…”

Section: Soy and Metabolic Programmingmentioning

confidence: 99%

“…Because of this estrogenic activity, the safety of its consumption in critical phases of development, as the gestation and lactation, has been questioned [10][11][12], as they may act as hormonal disruptors key systems that control the growth and development, permanent structural changes, generating metabolic and functional tissues and organism systems that can be attached to the development of chronic diseases; this process is called programming [13].…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between the Consumption of Soy and Its Derivatives During Critical Periods of Development and in Adulthood and Endocrine-Metabolic Disorders

Vieira¹,

Brasiel²,

Ferreira³

et al. 2017

J Endocrinol Metab

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The consumption of soybeans and their constituents, isolated soy protein and isoflavones, has been associated with positive effects on body weight, lipid profile and insulin, which has stimulated the production and consumption of foods derived from soy. However, these polyphenolic compounds (isoflavones) have similar structure to 17-β estradiol and may act as agonists or antagonists in estrogen receptors. Due to its estrogenic activity, the safety of its consumption during critical periods of development, such as gestation and lactation, has been questioned. Studies that evaluate the effects of soybeans on endocrine metabolic parameters are still controversial. This review focuses on the role that soy and isoflavones play during critical periods of development and into adulthood.

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Potential detrimental effects of a phytoestrogen-rich diet on male fertility in mice

Cited by 77 publications

References 48 publications

Soy, phytoestrogens and their impact on reproductive health

Soy, phytoestrogens and their impact on reproductive health

Effects of Transgenic Soybean and Organic Soybean on Rat Penis Morphology during the Aging Process

Relationship Between the Consumption of Soy and Its Derivatives During Critical Periods of Development and in Adulthood and Endocrine-Metabolic Disorders

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