Potential Diagnostic and Prognostic Biomarkers of Circular RNAs for Lung Cancer in China

Wang, Chengdi; Jiang, Yuting; Lei, Qian; Wu, Yangping; Shao, Jun; Pu, Dan; Liu, Weimin

doi:10.1155/2019/8023541

Cited by 9 publications

(8 citation statements)

References 68 publications

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“…It was seen apparently that the nanocomposite formed was from the prepared graphene followed by the linked GNP (Figure 2E). The fabrication of IDE surface was followed based on our established method using the silicon as the basic substrate and the aluminum electrodes were formed on the silicon as the dielectric 34,35. The fabricated IDE surface formed the clear finger and gap regions as observed under the SEM (Figure 3A).…”

Section: Resultsmentioning

confidence: 99%

<p>Glucose oxidase complexed gold-graphene nanocomposite on a dielectric surface for glucose detection: a strategy for gestational diabetes mellitus</p>

Ge¹,

Lakshmipriya²,

Gopinath³

et al. 2019

IJN

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BackgroundGestational diabetes mellitus is a commonly occurring metabolic disorder during pregnancy, affecting >4% of pregnant women. It is generally defined as the intolerance of glucose with the onset or initial diagnosis during pregnancy. This illness affects the placenta and poses a threat to the baby as it affects the supply of proper oxygen and nutrients.PurposeDue to the high percentage of affected pregnant women, it should be mandatory to evaluate glucose levels during pregnancy and there is a need for a continuous monitoring system.MethodsHerein, the investigators modified the interdigitated (di)electrodes (IDE) sensing surface to detect the glucose on covalently immobilized glucose oxidase (GOx) with the graphene. The characterization of graphene and gold nanoparticle (GNP) was performed by high-resolution microscopy.ResultsSensitivity was found to be 0.06 mg/mL and to enhance the detection, GOx was complexed with GNP. GNP-GOx was improved the sensitive detection twofold from 0.06 to 0.03 mg/mL, and it also displayed higher levels of current changes at all the concentrations of glucose that were tested. High-performance of the above IDE sensing system was attested by the specificity, reproducibility and higher sensitivity detections. Further, the linear regression analysis indicated the limit of detection to be between 0.02 and 0.03 mg/mL.ConclusionThis study demonstrated the potential strategy with nanocomposite for diagnosing gestational diabetes mellitus.

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Section: Resultsmentioning

confidence: 99%

<p>Glucose oxidase complexed gold-graphene nanocomposite on a dielectric surface for glucose detection: a strategy for gestational diabetes mellitus</p>

Ge¹,

Lakshmipriya²,

Gopinath³

et al. 2019

IJN

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“…Compelling evidence in the last decade indicated that circRNA play important roles in various cancer types [44–48]. In the present study, we compared the circRNA expression profiles in plasma exosomes isolated from CRC patients and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

CircFNDC3B sequestrates miR‐937‐5p to derepress TIMP3 and inhibit colorectal cancer progression

Zeng

Liu

et al. 2020

Molecular Oncology

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Circular RNA (circRNA) are single-stranded RNA with covalently closed 3 0 and 5 0 ends, with many recognized to be involved in human diseases as gene regulators, typically by interacting with other RNA. CircFNDC3B is a circRNA formed by back-splicing of exons 5 and 6 of the FNDC3B gene. CircFNDC3B was recently implicated in renal carcinoma, gastric and bladder cancer. However, the expression levels of circFNDC3B and its role in colorectal cancer (CRC) remain unclear. Expression of circFNDC3B and TIMP3 levels in CRC tissues and cell lines were found to be low, whereas microRNA (miR)-937-5p expression was high in CRC. Micro-RNA-937-5p downregulated TIMP3, thereby promoting tumor cell proliferation, invasion, migration and angiogenesis. Moreover, CircFNDC3B was shown to bind to miR-937-5p. CircFNDC3B and circFNDC3B-enriched exosomes inhibited tumorigenic, metastatic and angiogenic properties of CRC, and miR-937-5p overexpression or TIMP3 knockdown could reverse these effects. In vivo CRC tumor growth, angiogenesis and liver metastasis were suppressed by circFNDC3B overexpression, circFNDC3Benriched exosomes or miR-937-5p knockdown. In conclusion, our work reports a tumor-suppressing role for the circFNDC3B-miR-97-5p-TIMP3 pathway and suggests that circFNDC3B-enriched exosomes can inhibit angiogenesis and CRC progression.

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“…The detection of serum tumor markers, such as carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), cytokeratin 19 fragments (CYFRA 21-1), and epidermal growth factor receptor (EGFR), are important auxiliary means for the diagnosis and evaluation of the pathological types and clinical stages of lung cancer ( 7 ). However, there are still clinical challenges in improving the patient survival rate due unsatisfied early diagnosis based on the traditional methods ( 8 , 9 ). Thus, biomarkers for early diagnosis and prognosis of lung cancer are extremely needed.…”

Section: Overview Of the Lung Cancer Screening Methodsmentioning

confidence: 99%

Research progress regarding long-chain non-coding RNA in lung cancer: a narrative review

Yu¹,

He²,

Lu³

et al. 2022

J Thorac Dis

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Background and Objective: Lung cancer is the main cause of cancer-related death worldwide, and its incidence rate is high. Traditional methods of lung cancer screening, such as those based on X-ray, lowdose computed tomography (LDCT), positron emission computed tomography (PET/CT), electronic bronchoscopy, and serum tumor markers were not satisfied with the urgent need in improving the patient survival rate. Thus, biomarkers for early diagnosis and prognosis of lung cancer are extremely needed.Studies have identified a variety of long-chain non-coding RNAs (lncRNAs) that are expressed at abnormal levels in patients with lung cancer which was believed as a potential biomarker for the diagnosis and prognostic evaluation of lung cancer. This review aims to discuss the role of lncRNAs in non-small cell lung cancer (NSCLC), so as to provide insights into the prognosis of lung cancer. Methods:We searched PubMed database of the related scientific researches with outcomes from 09/16/2011 to 05/02/2022 focusing on lncRNA application in lung cancer via searching terms of "lncRNA AND lung cancer", "lncRNA AND non-small cell lung cancer", "lncRNA AND drug resistance", "lncRNA AND radio sensitivity". Published articles written in English available to readers were considered.

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Potential Diagnostic and Prognostic Biomarkers of Circular RNAs for Lung Cancer in China

Cited by 9 publications

References 68 publications

<p>Glucose oxidase complexed gold-graphene nanocomposite on a dielectric surface for glucose detection: a strategy for gestational diabetes mellitus</p>

<p>Glucose oxidase complexed gold-graphene nanocomposite on a dielectric surface for glucose detection: a strategy for gestational diabetes mellitus</p>

CircFNDC3B sequestrates miR‐937‐5p to derepress TIMP3 and inhibit colorectal cancer progression

Research progress regarding long-chain non-coding RNA in lung cancer: a narrative review

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