Potential for Adverse Drug‐Alcohol Interactions Among Retirement Community Residents

Adams, Wendy L.

doi:10.1111/j.1532-5415.1995.tb05567.x

Cited by 68 publications

(59 citation statements)

References 46 publications

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“…In another study among 311 drinkers (mean [SD] age, 83 [6] years) in 3 retirement communities in suburban Milwaukee, Wisconsin, 38% used drugs that could have negative interactions with alcohol [66]. A third study among a sample of 667 communitydwelling older adults (mean [SD] age, 74 [7] years) living in northeast New York estimated that 25% of them drank alcohol and took medication that could negatively interact with alcohol [67].…”

Section: Interaction With Medicationsmentioning

confidence: 99%

Alcohol and older people from a public health perspective

Anderson

Scafato

Galluzzo

2012

Annali Dell'Istituto Superiore Di Sanità

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Abstract. Objectives and methods. As part of the European project VINTAGE, a systematic review of scientific literature was undertaken to document the evidence base on the impact of alcohol on the health and well-being of older people, and on effective policies and preventive approaches to face the problem in this steadily increasing segment of the population. Results. 369 references were identified, from which 78 papers were selected. Conclusions. The review confirms the paucity of data on this topic and the need for more specific research. Although there is scarce evidence, the elderly seems to respond equally well to alcohol policy, screening instruments and brief interventions as do younger adults. According to a lifecycle approach, a future focus on the middle aged is also recommended.Key words: aged, alcohol drinking, public health, Europe, review.Riassunto (alcol e anziani in una prospettiva di salute pubblica). Obiettivi e Metodi. Nell'ambito del progetto europeo VINTAGE, è stata condotta una revisione sistematica della letteratura scientifica, al fine di fornire la base di evidenza sull'impatto del consumo di alcol sulla salute e il benessere degli anziani, e su misure e interventi di prevenzione efficaci nel fronteggiare il problema in questo segmento della popolazione in costante aumento. Risultati. Dai 369 riferimenti bibliografici identificati, sono stati selezionati 78 articoli. Conclusioni. La revisione conferma la carenza di dati sull'argomento e la necessità di ricerche mirate. Nonostante la scarsità di evidenze, sembra che gli anziani rispondano altrettanto bene degli adulti alle politiche sull'alcol, agli strumenti di screening e all'intervento breve. In un'ottica che investe l'intero arco della vita, si raccomanda di focalizzare gli interventi futuri anche sugli adulti.Parole chiave: anziani, assunzione di alcolici, salute pubblica, Europa, rassegna.

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Section: Interaction With Medicationsmentioning

confidence: 99%

Alcohol and older people from a public health perspective

Anderson

Scafato

Galluzzo

2012

Annali Dell'Istituto Superiore Di Sanità

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“…Yet, even with the rapid growth of CCRCs in recent years, little research has focused on alcohol use in these settings. Instead, much of the extant research has focused on residential retirement communities, such as Leisure World (Adams, 1995; Paganini-Hill, Kawas, & Corrada, 2007), rather than CCRCs. In some instances, the drinking quantity and frequency of drinking were found to be higher in these semi-structured communities than within general population-based samples (e.g.…”

Section: Introductionmentioning

confidence: 99%

Drinking behavior among older adults at a continuing care retirement community: affective and motivational influences

Sacco

Burruss

Smith

et al. 2014

Aging & Mental Health

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Objectives The purpose of this pilot study was to describe patterns of alcohol consumption among continuing care retirement community(CCRC) residents and to explore the role of drinking motives and affective states on drinking context and consumption. Method We utilized a phone-based daily diary approach to survey older adults about their daily alcohol consumption, context of drinking (e.g. drinking alone), positive and negative affect, and their motives for drinking. Data were analyzed descriptively, and regression models were developed to examine associations between sociodemographic factors, affect, drinking context and motives, and alcohol consumption. Results CCRC residents drank most frequently at home and were alone almost half of drinking days on average, although the context of drinking varied considerably by participant. Problem alcohol use was rare, but hazardous use due to specific comorbidities, symptoms and medications, and the amount of alcohol consumption was common. Respondents endorsed higher social motives for drinking and lower coping motives. Social motives were associated with decreased likelihood of drinking alone, but negative affect was associated with decreased likelihood of drinking outside one’s home. Coping and social motives were associated with greater consumption, and higher positive affect was associated with lower consumption. Conclusion Among CCRC residents, alcohol use may be socially motivated rather than motivated by coping with negative affect. Future research should examine other motives for drinking in older adulthood. Evaluation of older adults living in CCRCs should include attention to health factors beyond problem use as other forms of hazardous use may be common in CCRCs.

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“…While there are numerous studies examining the effect of other drugs on warfarin metabolism, mainly as a result of competitive displacement of warfarin from its binding site in subdomain 2A of HSA [14,18,21,22], there is no specific information on how various ethanol concentrations (0.1-0.5% v/v) may modulate the HSA/ warfarin interaction. One study showed that 47% of people in retirement communities drink alcohol on a weekly basis and 5% of that population reported the use of alcohol and warfarin concurrently [1]. Because almost all serum warfarin is bound to HSA (99%) small changes in the Kd for the warfarin/HSA interaction can significantly change the free fraction of the drug.…”

Section: Introductionmentioning

confidence: 99%

Investigations of the Effects of Ethanol on Warfarin Binding to Human Serum Albumin

Ha¹,

Petersen²,

Park³

et al. 2000

J Biomed Sci

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Ethanol effects on warfarin binding to human serum albumin (HSA) have been studied by equilibrium dialysis and fluorescence methods at pH 7.4 in phosphate-buffered saline at 37°C. In the presence of various amounts of ethanol fluorescence intensity of bound warfarin decreased significantly but this intensity reduction was not solely from displacement of bound warfarin from HSA. By comparing fluorescence and equilibrium dialysis data we concluded that fluorescence intensity reduction of warfarin was mainly the result of changes in the surrounding environment of the warfarin binding site by ethanol interaction with HSA and that displacement of bound warfarin was not significant compared to the fluorescence intensity changes. The dissociation constant of warfarin binding to HSA decreased with an increasing amount of ethanol. From the changes in fluorescence intensity upon warfarin binding to HSA with the presence of ethanol ranging from 0 to 5.0% the following dissociation constants (Kd) were determined: 0% ethanol 5.39 ± 0.2 μM, 0.1% ethanol 5.86 ± 0.1 μM, 0.3% ethanol 5.83 ± 0.2 μM, 0.5% ethanol 6.76 ± 0.1 μM, 1% ethanol 7.01 ± 0.1 μM, 3% ethanol 9.9 ± 0.7 μM, 5% ethanol 13.01 ± 0.1 μM. From the equilibrium dialysis with the same ranges of ethanol presence the following Kd values were obtained: 0% ethanol 6.62 ± 1.6 μM, 0.1% ethanol 6.81 ± 1.1 μM, 0.3% ethanol 8.26 ± 2.5 μM, 0.5% ethanol 8.86 ± 1.9 μM, 1% ethanol 11.01 ± 4.2 μM, 3% ethanol 20.75 ± 2.4 μM, 5% ethanol 21.67 ± 2.2 μM. The results suggest that warfarin bound to HSA was displaced by ethanol. These data indicate that ethanol influence on warfarin binding to HSA may alter the pharmacokinetics of warfarin.

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Potential for Adverse Drug‐Alcohol Interactions Among Retirement Community Residents

Cited by 68 publications

References 46 publications

Alcohol and older people from a public health perspective

Alcohol and older people from a public health perspective

Drinking behavior among older adults at a continuing care retirement community: affective and motivational influences

Investigations of the Effects of Ethanol on Warfarin Binding to Human Serum Albumin

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