Potential for sexual conflict assessed via testosterone-mediated transcriptional changes in liver and muscle of a songbird

Peterson, Mark P.; Rosvall, Kimberly A.; Taylor, Charlene A.; Lopez, Jacqueline; Choi, Jeong Hyeon; Ziegenfus, Charles; Tang, Haixu; Colbourne, John K.; Ketterson, Ellen D.

doi:10.1242/jeb.089813

Cited by 31 publications

(31 citation statements)

References 115 publications

(158 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In male juncos treated with T, the liver also responds with shifts in hundreds of genes related to growth and metabolism, e.g. insulin receptor 4, follistatin (Peterson et al 2014). Androgens also act on skeletal muscle to bring about various changes linked to muscle hypertrophy and activity in golden-collared manakins ( Manacus vitellinus , e.g.…”

Section: Gene Regulatory Responses To T and To Social Challengesmentioning

confidence: 99%

“…Androgens also act on skeletal muscle to bring about various changes linked to muscle hypertrophy and activity in golden-collared manakins ( Manacus vitellinus , e.g. insulin-like growth factor 1, parvalbumin, Fuxjager et al 2012) and several hundred genes related to energy metabolism in dark-eyed juncos (Peterson et al 2014), including those regulating insulin metabolism and cellular growth. Importantly, the direction of these shifts in gene regulation are largely consistent with T-enhanced breakdown of energy stores paired with T-induced muscle growth and energy availability – all effects that ought to be well suited for responding to a persistent social challenge.…”

Section: Gene Regulatory Responses To T and To Social Challengesmentioning

confidence: 99%

“…Here, we provide new analyses that represent a first pass at filling this gap by comparing two studies we have conducted in the dark-eyed junco: one study in which we assessed the genome-wide transcriptional response to T implants (Peterson et al 2013; Peterson et al 2014) and another in which we quantified transcriptional responses to a social challenge (Rosvall et al in prep., Rosvall et al 2012b; Rosvall et al 2014a). Critically, male juncos do not elevate T in response to social challenges under most circumstances (Rosvall et al 2014b), and the males in the social challenge experiment described here did not alter systemic T levels (Rosvall et al 2012b), thus allowing us to tease apart responses to systemic changes in T from other social effects on gene regulation.…”

Section: Gene Regulatory Responses To T and To Social Challengesmentioning

confidence: 99%

“…Both studies took place at or near the Mountain Lake Biological Station in the Jefferson National Forest, Virginia, USA during the early to mid-breeding season. The T-implant study occurred in early June 2010 using 12 males that were captured, implanted with either T or control implants (n = 6 each), and held in a semi-naturalistic outdoor aviary for 26 days prior to euthanasia and tissue harvesting (Peterson et al 2013; Peterson et al 2014). This implant regimen induces T levels at the high of the natural range of variation as well many changes in T-mediated behavioral and physiological phenotypes (Ketterson et al 1991; Ketterson et al 1996).…”

Section: Gene Regulatory Responses To T and To Social Challengesmentioning

confidence: 99%

See 3 more Smart Citations

Behavioral effects of social challenges and genomic mechanisms of social priming: What’s testosterone got to do with it?

Rosvall

Peterson

2014

Current Zoology

Self Cite

View full text Add to dashboard Cite

Social challenges from rival conspecifics are common in the lives of animals, and changes in an animal’s social environment can influence physiology and behavior in ways that appear to be adaptive in the face of continued social instability (i.e. social priming). Recently, it has become clear that testosterone, long thought to be the primary mediator of these effects, may not always change in response to social challenges, an observation that highlights gaps in our understanding of the proximate mechanisms by which animals respond to their social environment. Here, our goal is to address the degree to which testosterone mediates organismal responses to social cues. To this end, we review the behavioral and physiological consequences of social challenges, as well as their underlying hormonal and gene regulatory mechanisms. We also present a new case study from a wild songbird, the dark-eyed junco (Junco hyemalis), in which we find largely divergent genome-wide transcriptional changes induced by social challenges and testosterone, respectively, in muscle and liver tissue. Our review underscores the diversity of mechanisms that link the dynamic social environment with an organisms’ genomic, hormonal, and behavioral state. This diversity among species, and even among tissues within an organism, reveals new insights into the pattern and process by which evolution may alter proximate mechanisms of social priming.

show abstract

Section: Gene Regulatory Responses To T and To Social Challengesmentioning

confidence: 99%

Section: Gene Regulatory Responses To T and To Social Challengesmentioning

confidence: 99%

Section: Gene Regulatory Responses To T and To Social Challengesmentioning

confidence: 99%

Section: Gene Regulatory Responses To T and To Social Challengesmentioning

confidence: 99%

See 2 more Smart Citations

Behavioral effects of social challenges and genomic mechanisms of social priming: What’s testosterone got to do with it?

Rosvall

Peterson

2014

Current Zoology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Behavioural dominance often defines a male's access to mates (Qvarnström & Forsgren, ). Testosterone, which mediates the dominance hierarchy in males, can impose differential expression of many physiological pathways between males and females (Peterson et al., ). Testosterone can affect mating behaviour (Mills et al., ; Mokkonen, Koskela, Mappes, & Mills, ) and fitness: For example, red deer male calves born to first‐time mothers were less likely to survive if they had high neonatal testosterone level (Pavitt, Walling, Mcneilly, Pemberton, & Kruuk, ).…”

Section: Introductionmentioning

confidence: 99%

Maintenance costs of male dominance and sexually antagonistic selection in the wild

et al. 2018

View full text Add to dashboard Cite

Variation in dominance status determines male mating and reproductive success, but natural selection for male dominance can be detrimental or antagonistic for female performance, and ultimately their fitness. Attaining and maintaining a high dominance status in a population of competing individuals is physiologically costly for males. But how male dominance status is mediated by maintenance energetics is currently not well understood, nor are the corresponding effects of male energetics on his sisters recognized. We conducted laboratory and field experiments on rodent populations to test whether selective breeding for male dominance status (dominant vs. subordinate breeding lines) antagonistically affected basal metabolic rate (BMR) and fitness of females under wild conditions. Our results showed elevated BMR in females, but not in males, from the dominant breeding line. However, phenotypically dominant males from the subordinate breeding line had the highest BMR. Males from the dominant line with low BMR sired the most litters and offspring in the field. Similarly, females from the dominant selection line tended to have more offspring if they had lower BMR, while the opposite trend was found in females from the subordinate selection line. Females with high and low BMR reproduced most often, as indicated by a significant quadratic selection gradient. The increased female BMR resulting from selection for male dominance suggests genetic incompatibility between sexes in metabolism inheritance. Elevated BMR in behaviourally dominant males, but not in males from the dominant breeding line, suggests physiological costs in males not genetically suited for dominance. Fitness costs of elevated maintenance costs (measured as BMR) shown here support the energetic compensation hypothesis where high BMR is selected against as it would trade off energy required for other important life‐history attributes. A http://onlinelibrary.wiley.com/doi/10.1111/1365-2435.13216/suppinfo is available for this article.

show abstract

Sex‐ and Developmental Stage–Related Differences in the Hepatic Transcriptome of Japanese Quail (Coturnix japonica) Exposed to 17β‐Trenbolone

Mittal

Henry

Cornman

et al. 2021

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Endocrine‐disrupting chemicals can cause transcriptomic changes that may disrupt biological processes associated with reproductive function including metabolism, transport, and cell growth. We investigated effects from in ovo and dietary exposure to 17β‐trenbolone (at 0, 1, and 10 ppm) on the Japanese quail (Coturnix japonica) hepatic transcriptome. Our objectives were to identify differentially expressed hepatic genes, assess perturbations of biological pathways, and examine sex‐ and developmental stage–related differences. The number of significantly differentially expressed genes was higher in embryos than in adults. Male embryos exhibited greater differential gene expression than female embryos, whereas in adults, males and females exhibited similar numbers of differentially expressed genes (>2‐fold). Vitellogenin and apovitellenin‐1 were up‐regulated in male adults exposed to 10 ppm 17β‐trenbolone, and these birds also exhibited indications of immunomodulation. Functional grouping of differentially expressed genes identified processes including metabolism and transport of biomolecules, enzyme activity, and extracellular matrix interactions. Pathway enrichment analyses identified as perturbed peroxisome proliferator–activated receptor pathway, cardiac muscle contraction, gluconeogenesis, growth factor signaling, focal adhesion, and bile acid biosynthesis. One of the primary uses of 17β‐trenbolone is that of a growth promoter, and these results identify effects on mechanistic pathways related to steroidogenesis, cell proliferation, differentiation, growth, and metabolism of lipids and proteins. Environ Toxicol Chem 2021;40:2559–2570. © 2021 SETAC. This article has been contributed to by US Government employees and their work is in the public domain in the USA.

show abstract

Potential for sexual conflict assessed via testosterone-mediated transcriptional changes in liver and muscle of a songbird

Cited by 31 publications

References 115 publications

Behavioral effects of social challenges and genomic mechanisms of social priming: What’s testosterone got to do with it?

Behavioral effects of social challenges and genomic mechanisms of social priming: What’s testosterone got to do with it?

Maintenance costs of male dominance and sexually antagonistic selection in the wild

Sex‐ and Developmental Stage–Related Differences in the Hepatic Transcriptome of Japanese Quail (Coturnix japonica) Exposed to 17β‐Trenbolone

Contact Info

Product

Resources

About