Potential functionality of β-conglycinin with subunit deficiencies: soy protein may regulate glucose and lipid metabolism

Fu, Hongling; Shan, Dandan; Li, Jiaxin; Swallah, Mohammed Sharif; Yang, Xiaoqing; Ji, Lei; Wang, Sainan; Gong, Hao; Lyu, Bo; Yu, Hansong

doi:10.1039/d2fo02869g

Cited by 9 publications

(3 citation statements)

References 45 publications

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“…For example, β-conglycinin could inhibit the proliferation of cancer cells by inducing apoptosis and causing cell cycle arrest. Its bioactive peptides, released during digestion, can disrupt cancer cell signaling pathways, thereby reducing tumor growth and metastasis [98]. Peptides from pulses have shown anti-gastrointestinal cancer potential, peptides from common beans have impacted human colorectal cell lines, and the pulse proteins from common bean, fava bean, lupin, lentils, chickpea, and cowpea are associated with antiproliferative effects and reduced cell migration [8].…”

Section: Antitumoral Activitymentioning

confidence: 99%

Proteins from Legumes, Cereals, and Pseudo-Cereals: Composition, Modification, Bioactivities, and Applications

Zhang,

Boateng,

et al. 2024

Foods

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This review presents a comprehensive analysis of plant-based proteins from soybeans, pulses, cereals, and pseudo-cereals by examining their structural properties, modification techniques, bioactivities, and applicability in food systems. It addresses the critical need for a proper utilization strategy of proteins from various plant sources amidst the rising environmental footprint of animal protein production. The inherent composition diversity among plant proteins, their nutritional profiles, digestibility, environmental impacts, and consumer acceptance are compared. The innovative modification techniques to enhance the functional properties of plant proteins are also discussed. The review also investigates the bioactive properties of plant proteins, including their antioxidant, antimicrobial, and antitumoral activities, and their role in developing meat analogs, dairy alternatives, baked goods, and 3D-printed foods. It underscores the consideration parameters of using plant proteins as sustainable, nutritious, and functional ingredients and advocates for research to overcome sensory and functional challenges for improved consumer acceptance and marketability.

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Section: Antitumoral Activitymentioning

confidence: 99%

Proteins from Legumes, Cereals, and Pseudo-Cereals: Composition, Modification, Bioactivities, and Applications

Zhang,

Boateng,

et al. 2024

Foods

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“…When hungry, skin tissue can utilize fatty acids as a source of energy. In addition, lipids play important roles in supporting the basic structure of skin cells and preventing skin water loss [33,34]. An important characteristic of lipid metabolism in aging skin is a decrease in protective lipid synthesis and secretion.…”

Section: Lipid Metabolismmentioning

confidence: 99%

Research Progress in Skin Aging, Metabolism, and Related Products

He,

Gao,

Xie

2023

IJMS

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In recent years, skin aging has received increasing attention. Many factors affect skin aging, and research has shown that metabolism plays a vital role in skin aging, but there needs to be a more systematic review. This article reviews the interaction between skin metabolism and aging from the perspectives of glucose, protein, and lipid metabolism and explores relevant strategies for skin metabolism regulation. We found that skin aging affects the metabolism of three major substances, which are glucose, protein, and lipids, and the metabolism of the three major substances in the skin also affects the process of skin aging. Some drugs or compounds can regulate the metabolic disorders mentioned above to exert anti-aging effects. Currently, there are a variety of products, but most of them focus on improving skin collagen levels. Skin aging is closely related to metabolism, and they interact with each other. Regulating specific metabolic disorders in the skin is an important anti-aging strategy. Research and development have focused on improving collagen levels, while the regulation of other skin glycosylation and lipid disorders including key membrane or cytoskeleton proteins is relatively rare. Further research and development are expected.

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“…Researchers are still preferring to use the logic of nutrient classification to analyze the functionality of soy components. But in reality, it is the many subdivided components that are functional, such as β-globulin [part of soybean protein, which can affect the body's glycolipid metabolism ( 22 )], diglycerides [part of soybean oil, which can reduce visceral fat ( 23 )], stachyose [part of soybean oligosaccharides, which can meet the needs of people with diseases ( 24 )]. In addition, whether there are other subdivided components with physiological functions is to be further explored.…”

Section: Development Prospectsmentioning

confidence: 99%

Editorial: Innovative high value-added processing of soybean and its by-products

Lyu

Wang

et al. 2023

Front. Nutr.

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Potential functionality of β-conglycinin with subunit deficiencies: soy protein may regulate glucose and lipid metabolism

Abstract: 3T3-L1 pre-adipocytes were used to reveal the impact of subunit-deficient β-conglycinin on cell proliferation, cell adipogenesis, and proteomic expression, and to gain insight into the potential of subunit-deficient β-conglycinin's functional characteristics.

Cited by 9 publications

References 45 publications

Proteins from Legumes, Cereals, and Pseudo-Cereals: Composition, Modification, Bioactivities, and Applications

Proteins from Legumes, Cereals, and Pseudo-Cereals: Composition, Modification, Bioactivities, and Applications

Research Progress in Skin Aging, Metabolism, and Related Products

Editorial: Innovative high value-added processing of soybean and its by-products

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