Potential Involvement of the Stem Cell Factor Receptor c-kit in Alopecia Areata and Androgenetic Alopecia: Histopathological, Immunohistochemical, and Semiquantitative Investigations

Ashrafuzzaman, Md.; Yamamoto, Tomoko; Shibata, Noriyuki; Hirayama, Takeshi; Kobayashi, Makio

doi:10.1267/ahc.09032

Cited by 11 publications

(5 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the mean number of c‐kit‐immunoreactive cells per follicle was significantly increased. This upregulation may reflect a negative feedback mechanism in response to possible downregulation of the ligand stem cell factor similar to that seen in AGA in the same study 29 . Stem cell involvement was demonstrated in two elderly women with AA with unusual lymphocytic cell infiltrates surrounding both the bulge and the bulbar regions.…”

Section: Nonscarring Alopeciasupporting

confidence: 54%

“…In addition, another study by Ashrafuzzaman et al. 29 showed that the mean length of hair follicles was significantly shorter in the AGA groups than in the control group and similarly the mean number of Ki‐67‐immunoreactive cells per follicle was significantly reduced. Another report has indicated that mice lacking in functional vitamin D receptors develop a functional first coat of hair but lack the cyclic regeneration of hair follicles, leading to the development of alopecia 30 .…”

Section: Nonscarring Alopeciamentioning

confidence: 92%

See 1 more Smart Citation

Stem cells and alopecia: a review of pathogenesis

Al-Refu

2012

British Journal of Dermatology

View full text Add to dashboard Cite

Recent work has focused on the hair follicle as the main source of multipotent stem cells in the skin. The hair follicle bulge contains multipotent stem cells that can form the epidermis, hair follicles and sebaceous glands and help in repopulation of the epidermis after injury. The localization of these stem cells to the bulge area may explain why some types of inflammatory alopecia cause permanent loss of hair (cicatricial alopecia) (such as lichen planopilaris and discoid lupus erythematosus), while others (such as alopecia areata) are reversible (noncicatricial alopecia). The lack of distinctive bulge morphology in human hair follicles has hampered studies of bulge cells. To date, the best marker for bulge stem cells in human hair is cytokeratin (CK) 15; human bulge cells have been reported to express CK15 selectively throughout all stages of the hair cycle in different types of follicles. There is direct evidence in the mouse, and indirect evidence in the human, that compromising the integrity of the sebaceous gland and/or bulge is important in the development of alopecia. Several interesting studies have been done in the last few years to investigate the role of stem cells in alopecia, especially nonscarring types. This is a review about the role of stem cells in the pathogenesis of alopecia (scarring and nonscarring).

show abstract

Section: Nonscarring Alopeciasupporting

confidence: 54%

Section: Nonscarring Alopeciamentioning

confidence: 92%

Stem cells and alopecia: a review of pathogenesis

Al-Refu

2012

British Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…Androgenic alopecia (AGA) is a common type of hair loss, which is known as the result of interaction between 5a-DHT level and genetic predisposition [ 143 ]. Several researches have indicated the roles of HFTs in the onset of AGA [ 144 , 145 ]. However, not all types of HFTs but the specific CD200-rich and CD34-positive HFSCs are mainly in deficiency in the bald scalp of AGA patients [ 146 ].…”

Section: Emerging Roles In Non-malignant Skin Disordersmentioning

confidence: 99%

The PI3K/Akt Pathway: Emerging Roles in Skin Homeostasis and a Group of Non-Malignant Skin Disorders

Teng

Fan

et al. 2021

Cells

View full text Add to dashboard Cite

The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway regulates cell proliferation, differentiation, and migration, along with angiogenesis and metabolism. Additionally, it could mediate skin development and homeostasis. There is much evidence to suggest that dysregulation of PI3K/Akt pathway is frequently associated with several human cutaneous malignancies like malignant melanoma (MM), basal cell carcinoma (BCC), and cutaneous squamous cell carcinoma (SCC), as well as their poor outcomes. Nevertheless, emerging roles of PI3K/Akt pathway cascade in a group of common non-malignant skin disorders including acne and psoriasis, among others, have been recognized. The enhanced understanding of dysfunction of PI3K/Akt pathway in patients with these non-malignant disorders has offered a solid foundation for the progress of updated therapeutic targets. This article reviews the latest advances in the roles of PI3K/Akt pathway and their targets in the skin homeostasis and progression of a wide range of non-malignant skin disorders and describes the current progress in preclinical and clinical researches on the involvement of PI3K/Akt pathway targeted therapies.

show abstract

“…There have been number of immunohistochemical markers used to study or to detect the bulge regions of the hair follicles but many of them such as Ki‐67 and c‐kit fail to show specific staining of the bulge area. While several markers have been reported positive for the vicinity of the bulge stem cells including one for CD 200 and CD34, the clone C8/144b of cytokeratin 15 has consistently demonstrated the bulge stem cell region and it is known to show normal hair differentiation in in vitro study .…”

Section: Discussionmentioning

confidence: 99%