The development of leading commodities in a region must be based on its potential and development opportunities. Various benchmarks can be used as a basis for determining the leading commodities includes Location Quotient (LQ). The study aims to determine the potential leading commodities and its development area in Sigi District. The research was conducted in November 2020-Februari 2021. The data collected were primary and secondary data, which secondary data was in the form of harvested areas time series of agricultural commodities in the 2013-2018 periods. Moreover, primary data was collected through Focus Group Discussion and interview using questionnaire. The leading commodities were analyzed using the LQ while the area development of leading commodities was determined by Technique for Others Preference by Similarity to Ideal Solution (TOPSIS). Criteria for TOPSIS included agroecosystems, water availability, infrastructure, human resource, and support-systems. Based on Location Quotient, the annual commodities of corn, groundnut, green beans, cassava, shallot, Chinese cabbage, tomato and perennial commodities namely clove, nutmeg, coffee, candlenut, cocoa, and vanilla were classified as leading commodities in Sigi District. The potential development area model for shallot is Oloboju Village, Biromaru Sub-District while the potential development area model for corn is Pesaku Village, Dolo Barat Sub-District.