Potential mechanisms for the effects of far-infrared on the cardiovascular system – a review

Shemilt, Richard; Bagabir, Hala Abubaker; Lang, Chim C.; Khan, Faisel

doi:10.1024/0301-1526/a000752

Cited by 15 publications

(26 citation statements)

References 59 publications

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“…After the IR source was removed, the venous flow diminished below the baseline. This positive effect of IR agrees with the results of previous studies (39,40).…”

Section: Resultssupporting

confidence: 93%

On the Driver of Blood Circulation Beyond the Heart

Pollack

2021

Preprint

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The heart is widely acknowledged as the unique driver of blood circulation. Recently, we discovered a flow-driving mechanism that can operate without imposed pressure, using infrared (IR) energy to propel flow. We considered the possibility that, by exploiting this mechanism, blood vessels, themselves, could propel flow. We verified the existence of this driving mechanism by using a three-day-old chick-embryo model. When the heart was stopped, blood continued to flow, albeit at a lower velocity. When IR was introduced, flow increased, by ~300%. When IR energy was diminished under otherwise physiological conditions, blood failed to flow. Hence, this IR-dependent, vessel-based flow-driving mechanism may indeed operate in the circulatory system, complementing the action of the heart.

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“…After the IR source was removed, the venous flow diminished below the baseline. This positive effect of IR agrees with the results of previous studies (39,40).…”

Section: Resultssupporting

confidence: 93%

On the Driver of Blood Circulation Beyond the Heart

Pollack

2021

Preprint

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“…Similarly, FIR significantly prevented cisplatin‐evoked decreased capillary tube–like formation in HUVECs, while the event was strongly diminished by transfection with HIF‐1α siRNA, indicating the involvement of HIF‐1α in the proangiogenic activity of FIR. Previous studies have confirmed that FIR is able to alleviate ischemia/reperfusion injury and the poor blood flow in ischemic hindlimb of diabetic mice by enhancing endothelial progenitor cell functions and activating eNOS/NO cascade 29–31 . Accordingly, FIR has a therapeutic potential for ischemia‐associated cardiovascular diseases by augmenting HIF‐1α–dependent new vessel formation and vasodilation.…”

Section: Discussionmentioning

confidence: 90%

“…Several studies have confirmed that far‐infrared radiation (FIR) exhibits a protective effect against cardiovascular disorders and endothelial inflammation via heme oxygenase‐1 induction 15,16 …”

Section: Introductionmentioning

confidence: 99%

Far‐infrared radiation alleviates cisplatin‐induced vascular damage and impaired circulation via activation of HIF‐1α

Chen

Hsu

et al. 2022

Cancer Science

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Severe vascular damage and complications are often observed in cancer patients during treatment with chemotherapeutic drugs such as cisplatin. Thus, development of potential options to ameliorate the vascular side effects is urgently needed. In this study, the effects and the underlying mechanisms of far-infrared radiation (FIR) on cisplatin-induced vascular injury and endothelial cytotoxicity/dysfunction in mice and human umbilical vein endothelial cells (HUVECs) were investigated. An important finding is that the severe vascular stenosis and poor blood flow seen in cisplatintreated mice were greatly mitigated by FIR irradiation (30 minutes/day) for 1-3 days.Moreover, FIR markedly increased the levels of phosphorylation of PI3K and Akt, and VEGF secretion, as well as the expression and the activity of hypoxia-inducible factor 1α (HIF-1α) in cisplatin-treated HUVECs in a promyelocytic leukemia zinc finger protein (PLZF)-dependent manner. However, FIR-stimulated endothelial angiogenesis and VEGF release were significantly diminished by transfection with HIF-1α siRNA.We also confirmed that HIF-1α, PI3K, and PLZF contribute to the inhibitory effect of FIR on cisplatin-induced apoptosis in HUVECs. Notably, FIR did not affect the anticancer activity and the HIF-1α/VEGF cascade in cisplatin-treated cancer cells under normoxic or hypoxic condition, indicating that the actions of FIR may specifically target endothelial cells. It is the first study to demonstrate that FIR effectively attenuates cisplatin-induced vascular damage and impaired angiogenesis through activation of HIF-1α-dependent processes via regulation of PLZF and PI3K/Akt. Taken together, cotreatment with the noninvasive and easily performed FIR has a therapeutic potential to prevent the pathogenesis of vascular complications in cancer patients during cisplatin treatment.

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“…Animal studies have shown that far-infrared mechanisms include the activation of oxidative stress and heat shock proteins. Clinical studies have shown that FIR may have therapeutic effects on heart failure and myocardial ischemia and may improve the flow rate and survival rate of arteriovenous fistulas [ 25 ], implying that FIR may have a certain recovery effect on inflammation injury in living organisms. Proteomics research methods were adopted to further explain the mechanism of the SEW and FIR intervention.…”

Section: Discussionmentioning

confidence: 99%