Potential mechanisms for the hypothesized link between sunshine, vitamin D, and food allergy in children

Vassallo, Milo F.; Camargo, Carlos A.

doi:10.1016/j.jaci.2010.06.011

Cited by 136 publications

(120 citation statements)

References 70 publications

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“…16,17 Epidemiologic data have shown a higher prevalence of allergic diseases, including AD, food allergy, and anaphylaxis, at higher latitudes, used as a proxy of sun exposure. 11,18,19 Lower 25OHD levels also appear to correlate with AD severity, which suggests a potential role of VD in the pathogenesis of AD. 5 A prospective birth cohort study supported this association by showing that infants born with cord blood 25OHD levels of ,50 nmol/L had a higher risk of AD at 12 months of age.…”

Section: Discussionmentioning

confidence: 92%

“…10 Extremely low levels of 25OHD (,12 nmol/L) are associated with development of rickets or osteomalacia, but insufficient levels (,75 nmol/L) are linked to a wide variety of nonskeletal diseases including infections and allergies. 11 Adequate sunlight exposure is the most cost-effective means of obtaining VD, because most VD in humans is synthesized from precursors in the skin to VD 3 . Some foods such as oily fish also contain VD 3 .…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D Deficiency Rickets in an Adolescent With Severe Atopic Dermatitis

et al. 2014

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Atopic dermatitis (AD) affects 10% to 20% of children worldwide. Its severity may be inversely correlated with 25-hydroxyvitamin D (25OHD) levels. Although low levels of vitamin D (VD) can cause rickets in infants, VD deficiency rickets is an unusual presentation in teenagers. We report the case of a 14-year-old girl with severe AD and fish allergy since early childhood. She lived at high latitude (with less sun exposure) and, because of her atopic disorders, avoided sunlight and fish. Laboratory studies showed elevated alkaline phosphatase and parathyroid hormone levels and low serum calcium; her serum 25OHD level was ,12 nmol/L. A radiograph of the wrist showed a radiolucent band in the distal metaphysis of the radius with marginal sclerosis. She was diagnosed as having hypocalcemic rickets due to VD deficiency. Treatment with VD increased her 25OHD level to 44 nmol/L, with normalization of alkaline phosphatase, parathyroid hormone, and calcium. Moreover, we observed a dramatic improvement in her AD severity with VD treatment. This case demonstrates the complex interaction between VD deficiency, AD, and food allergy. We advise a high index of suspicion of VD deficiency rickets in children of all ages with AD, particularly during accelerated growth periods and in the presence of other risk factors such as darker skin, living at high latitude, sun avoidance, and low intake of VD-rich foods. The concomitant improvement in bone-related parameters and AD severity may reflect a double benefit of VD treatment, a possibility that warrants research on VD as potential treatment for AD.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency Rickets in an Adolescent With Severe Atopic Dermatitis

et al. 2014

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“…Vitamin D deficiency is more common reported worldwide than considered to be. Various estimates up to 30-80% vitamin D deficiency have been reported in the literature [6]. NHANES (2001-4) study of 6.000 individuals of 1-21 year olds in USA demonstrated 9% vitamin D deficient (<15ng/ml) and 61% vitamin D insufficient (<30ng/ ml) subjects.…”

Section: Vitamin D Deficiencymentioning

confidence: 99%

“…Whether low vitamin D levels are primary or secondary to allergic disease is not clear [2][3][4][5][6]. For instance: since more severe asthmatic patients spend less time outdoors, this situation is an apparent cause of vitamin D deficiency, owing to the disease [2].…”

Section: Vitamin D Deficiencymentioning

confidence: 99%

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Vitamin D and Allergy

Özdemir¹

2016

MOJI

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After the modern vitamin D hypothesis firstly suggested in 1999 for the allergy pandemic, numerous conditions have been thought to be associated with vitamin D deficiency such as allergy, autoimmunity and neoplasm. Consistently, previous observational studies have linked lower vitamin D status to increased markers of atopy and allergic diseases e.g. atopic dermatitis, anaphylaxis and food allergy. Vitamin D is a "hormone" having important immunomodulatory and immunoregulatory properties. In vitamin D deficient conditions, disrupted mucosal and skin complex integrity and intercurrent infections may act synergistically with allergenic exposure to amplify sensitization risk. There has been emerging data to show that vitamin D can enhance the anti-inflammatory effects of glucocorticoids and potentially be used as adjuvant therapy in steroid-resistant severe asthma. And recent in vivo data suggest that vitamin D supplementation reduce the severity of eczema and allergic rhinitis as well as urticaria symptoms. However, there is presently inadequate evidence to support daily vitamin D supplementation in the prevention and/or treatment of allergic diseases in infants, children and adolescents.

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Peanut thresholds in peanut‐allergic children are related to dietary composition

Luiten,

Biezeveld,

van Doorn

et al. 2023

Immunity Inflam & Disease

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Background: There is no clear explanation for the large variation in threshold levels among peanut-allergic children. We hypothesized that diet composition can partly explain this variation in thresholds, as nutrients and foods influence the intestinal barrier function and microbiota.Aim: to explore the relationship between the threshold levels for peanut and nutritional intake and gut microbial composition in peanut-allergic children.Methods: In this explorative cross-sectional study the cumulative threshold levels for peanut were determined by oral food challenge tests. Data on

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Potential mechanisms for the hypothesized link between sunshine, vitamin D, and food allergy in children

Cited by 136 publications

References 70 publications

Vitamin D Deficiency Rickets in an Adolescent With Severe Atopic Dermatitis

Vitamin D Deficiency Rickets in an Adolescent With Severe Atopic Dermatitis

Vitamin D and Allergy

Peanut thresholds in peanut‐allergic children are related to dietary composition

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