Potential mechanisms of Chinese Herbal Medicine that implicated in the treatment of COVID-19 related renal injury

Abstract

Highlight: It was proven that renal injury in Corona Virus Disease 2019 (COVID-19) patients has been a real concern. There are three possible mechanisms of renal injury in COVID-19 infection: direct viral mediated, prolonged cytokine storm mediated, and drug-induced renal injury. There is no targeted drug therapy in the treatment of renal injury, while Chinese Herbal Medicine can be a potential solution. Huang Qi, Fu Ling, Di Huang, Shan Yao and Bai Zhu are the core herbs in Chinese Herbal Medicine to treat renal injury. Chinese Herbal Medicine may act on PTGS2, PTGS1, IL6 and CASP3, etc., to prevent the pharmacological and non-pharmacological COVID-19 related renal injury.

Effectiveness of Chinese herbal medicine combined with Western medicine on deferring dialysis initiation for nondialysis chronic kidney disease stage 5 patients: a multicenter prospective nonrandomized controlled study

“…He et al collected prescriptions for the treatment of renal injury in CHM clinical reports from databases such as the China National Knowledge Infrastructure (CNKI), VIP, and Wanfang. Frequency statistics were performed on herbs among all the prescriptions recorded, and the association rules analysis showed that the core herbs included Huang Qi (Radix astragali), Fu Ling (Poria), Bai Zhu (Rhizoma atractylodis macrocephalae), Shan Yao (Rhizoma dioscoreae), and Di Huang (Radix rehmanniae) (15), which was generally consistent with the clinical medications of this study. Huang Qi, Fu Ling, Bai Zhu, and Shan Yao strengthen the spleen, benefit Qi, and remove dampness.…”

Network pharmacology, molecular docking integrated surface plasmon resonance technology reveals the mechanism of Toujie Quwen Granules against coronavirus disease 2019 pneumonia

“…3 , the proteins in the center of the PPI are PTGS2, IL6, TNF, MAPK14, and so on, which may play an important role in the treatment of COVID-19 with TQG. PTGS2, encoding COX2, plays an important role in SARS-CoV infections and SARS-CoV N protein causes lung inflammation by activating COX2 and stimulating multiple COX2 inflammatory cascades ( Elkahloun and Saavedra, 2020 ; He et al., 2020 ). IL-6 plays an important role in the immunopathogenesis of COVID-19 and is supported by data from a range of studies reporting increased serum concentrations of this cytokine, foremost in the severe cases ( Nasonov and Samsonov, 2020 ).…”

Traditional Chinese medicine in COVID-19

“…Although a great quantity of review articles have been published on the topic of TCM in COVID-19 13 , 14 , 19 , 23 , 25 , 35 , 71 , 87 , 168 , 171 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 , 253 , 254 , 255 , 256 , 257 , 258 , 259 , 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 277 , our work offers something unique. 1) To our knowledge, this is the first review of TCM on COVID-19 that integrates evidence-based scientific findings from bedside to bench with the most comprehensive and updated literatures.…”