Potential Modulatory Microbiome Therapies for Prevention or Treatment of Inflammatory Bowel Diseases

Bunt, Daan V.; Minnaard, Adriaan J.; Aidy, Sahar El

doi:10.3390/ph14060506

Cited by 10 publications

(6 citation statements)

References 116 publications

(134 reference statements)

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“…Additionally, researchers carry out a research to examine the effect of mucinutilizing bacteria, and confirm that commensal P. russellii plays a role in reducing the susceptibility to colitis by metabolizing tryptophan to IA, through which, goblet cell differentiation is improved and inflammatory signal is reduced[ 124 ]. The same pathway occurs for IA in P. russellii.…”

Section: Tryptophan Metabolismmentioning

confidence: 99%

Role of metabolites derived from gut microbiota in inflammatory bowel disease

Wen¹,

Duan²

2022

WJCC

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Over the past two decades, it is improved gut microbiota plays an important role in the health and disease pathogenesis. Metabolites, small molecules produced as intermediate or end products of microbial metabolism, is considered as one of the major interaction way for gut microbiota with the host. Bacterial metabolisms of dietary substrates, modification of host molecules or bacteria are the major source of metabolites. Signals from microbial metabolites affect immune maturation and homeostasis, host energy metabolism as well as mucosal integrity maintenance. Based on many researches, the composition and function of the microbiota can be changed, which is also seen in the metabolite profiles of patients with inflammatory bowel disease (IBD). Additionally, some specific classes of metabolites also can trigger IBD. In this paper, definition of the key classes of microbial-derived metabolites which are changed in IBD, description of the pathophysiological basis of association and identification of the precision therapeutic modulation in the future are the major contents.

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Section: Tryptophan Metabolismmentioning

confidence: 99%

Role of metabolites derived from gut microbiota in inflammatory bowel disease

Wen¹,

Duan²

2022

WJCC

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“…Disturbances in the interaction between the intestinal flora and the mucosal immune system play a key role in the development of UC and are usually associated with reduced flora diversity and imbalances in strain composition (Bunt et al, 2021 ). Dysbiosis usually leads to a decrease in the production of short-chain fatty acids, which reduces an important source of energy for intestinal epithelial cells, leading to increased intestinal permeability and triggering inflammation (Wu et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Integrative analysis revealed the role of glucagon-like peptide-2 in improving experimental colitis in mice by inhibiting inflammatory pathways, regulating glucose metabolism, and modulating gut microbiota

Gao

Cui

et al. 2023

Front. Microbiol.

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IntroductionUlcerative colitis (UC) is an inflammatory bowel disease characterized by recurrent and remitting inflammation of the mucosa of the colon and rectum, the incidence of which is on the rise. Glucagon-like peptide-2 (GLP-2) is a newly discovered neurotrophic factor, but its efficacy and mechanism of action in UC remain unclear. In this study, we investigated the protective effects and potential targets of GLP-2 on dextran sodium sulfate (DSS)-induced UC in mice through integrative analysis.MethodsThe effects of GLP-2 on UC were assessed by calculating the disease activity index, colonic mucosal damage index, and pathological histological scores. Enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry were used to detect the expression of GLP-2, nuclear factor kappa-B (NF-κB), interleukin-6 (IL-6), and signal transducer and activator of transcription-3 (STAT3). The 16SrRNA gene was used to detect changes in gut microbiota in mouse colonic tissues, and oral glucose tolerance test (OGTT) blood glucose levels were used to analyze the differences in flora.ResultsThe results showed that GLP-2 could reduce the inflammation of UC mice, which may be achieved by inhibiting the potential targets of NF-κB, and Janus kinase (JAK)/STAT3 inflammatory pathways, regulating sugar metabolism, increasing dominant species, and improving microbial diversity.DiscussionThis study provides new insight into the potential of GLP-2 for achieving more ideal UC treatment goals in future.

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“…It has been proved that Catenibacillus could perform deglycosylation reaction for aromatic C-glucosides and flavonoid O-glucosides producing protocatechuic acid, 3,4-dihydroxyphenylacetic acid and 3,4-dihydroxyphenylpropionic acid, which exhibited antioxidant effects by decreasing the contents of NO, H 2 O 2 and MDA. 51,52 Additionally, the relative abundance of Peptococcus was increased by antioxidant supplementation (vitamin E, selenium-enriched yeast and soy isoflavone) and positively associated with Nrf2 gene expression, total antioxidant capacity and activities of SOD, GSH-Px and catalase. 53,54 In this study, total flavonoid content was higher in the UV-C irradiated peanut sprouts than in the dark germinated peanut sprouts (Table S2 †).…”

Section: Papermentioning

confidence: 99%