2001
DOI: 10.1897/1551-5028(2001)020<0198:pmrgpa>2.0.co;2
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Potential Multidrug Resistance Gene Pohl: An Ecologically Relevant Indicator in Marine Sponges

Abstract: Sponges are sessile filter feeders found in all aquatic habitats from the tropics to the arctic. Against potential environmental hazards, they are provided with efficient defense systems, e.g., protecting chaperones and/or the P-170/multidrug resistance pump system. Here we report on a further multidrug resistance pathway that is related to the pad one homologue (POH1) mechanism recently identified in humans. It is suggested that proteolysis is involved in the inactivation of xenobiotics by the POH1 system. Tw… Show more

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(1 citation statement)
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“…heat-shock proteins (Koziol et al 1997), targeting chaperones like the 14-3-3 protein(s) (Wiens et al 1998), multidrug resistance (MDR) (reviewed in Kurelec 1997) or thioredoxin (Wiens et al 1999) and by (2) organismic protection, including a well-developed immune system ) and bioactive secondary metabolites (Sarma et al 1993, Proksch 1994. Recently, we also identified the second MDR-system, related to the POHl Lpad one homologoue] mechanisms (Spataro et al 1997), which is thought to 'eliminate' pollutants via an enzymatic route (Krasko et al 2000).…”
Section: Introductionmentioning
confidence: 99%
“…heat-shock proteins (Koziol et al 1997), targeting chaperones like the 14-3-3 protein(s) (Wiens et al 1998), multidrug resistance (MDR) (reviewed in Kurelec 1997) or thioredoxin (Wiens et al 1999) and by (2) organismic protection, including a well-developed immune system ) and bioactive secondary metabolites (Sarma et al 1993, Proksch 1994. Recently, we also identified the second MDR-system, related to the POHl Lpad one homologoue] mechanisms (Spataro et al 1997), which is thought to 'eliminate' pollutants via an enzymatic route (Krasko et al 2000).…”
Section: Introductionmentioning
confidence: 99%