Potential new biomarkers for endometrial cancer

Townsend, Michelle H.; Ence, Zac E.; Felsted, Abigail M.; Parker, Alyssa; Piccolo, Stephen R.; Robison, Richard A.; O’Neill, Kim L.

doi:10.1186/s12935-019-0731-3

Cited by 44 publications

(34 citation statements)

References 47 publications

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“…EZH2 has been reported to interact with TERF2 and TERF2IP [ 131 ], of the shelterin complex, and also telomeric repeat-containing RNA ( TERRA ) [ 132 , 133 ]. In our survival analysis, AURKA and CCNA2 were identified as markers of unfavourable prognosis ( Table S34 ), which is supported by previous immunohistochemical studies [ 122 , 134 ]. Polymorphisms within the RAD51 gene have been associated with EC progression and recurrence [ 135 , 136 ].…”

Section: Discussionsupporting

confidence: 87%

Investigating the Role of Telomere and Telomerase Associated Genes and Proteins in Endometrial Cancer

Bradfield

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Hill

et al. 2020

MPs

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Endometrial cancer (EC) is the commonest gynaecological malignancy. Current prognostic markers are inadequate to accurately predict patient survival, necessitating novel prognostic markers, to improve treatment strategies. Telomerase has a unique role within the endometrium, whilst aberrant telomerase activity is a hallmark of many cancers. The aim of the current in silico study is to investigate the role of telomere and telomerase associated genes and proteins (TTAGPs) in EC to identify potential prognostic markers and therapeutic targets. Analysis of RNA-seq data from The Cancer Genome Atlas identified differentially expressed genes (DEGs) in EC (568 TTAGPs out of 3467) and ascertained DEGs associated with histological subtypes, higher grade endometrioid tumours and late stage EC. Functional analysis demonstrated that DEGs were predominantly involved in cell cycle regulation, while the survival analysis identified 69 DEGs associated with prognosis. The protein-protein interaction network constructed facilitated the identification of hub genes, enriched transcription factor binding sites and drugs that may target the network. Thus, our in silico methods distinguished many critical genes associated with telomere maintenance that were previously unknown to contribute to EC carcinogenesis and prognosis, including NOP56, WFS1, ANAPC4 and TUBB4A. Probing the prognostic and therapeutic utility of these novel TTAGP markers will form an exciting basis for future research.

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Section: Discussionsupporting

confidence: 87%

Investigating the Role of Telomere and Telomerase Associated Genes and Proteins in Endometrial Cancer

Bradfield

Button

Hill

et al. 2020

MPs

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“…Searching for effective biomarkers for early diagnosis, prognosis, and therapeutic targets for the treatment of lung cancer is still essential. Increasing studies have identified that molecular markers including miRNAs play an important role in the diagnosis and/or prognosis in various cancers [21–24]. For instance, miR-23a as one of the most extensively studied miRNAs in various cancers plays an essential role in the application of cancer diagnosis, prognosis, and treatment [23].…”

Section: Discussionmentioning

confidence: 99%

Overexpression of microRNA-423-3p indicates poor prognosis and promotes cell proliferation, migration, and invasion of lung cancer

Wang

Li²,

Zhuang³

et al. 2019

Diagn Pathol

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Background Lung cancer is one of the common malignant tumors worldwide with high incidence and mortality. MicroRNA-423-3p (miR-423-3p) acts as an oncogene in several types of cancers. The aim of this study is to reveal the clinical significance and biological function of miR-423-3p in lung cancer. Methods The expression of miR-423-3p was detected in lung cancer specimens by reverse transcription-quantitative polymerase chain reaction (qRT-PCR) assay. Kaplan-Meier survival and Cox regression analyses were used to investigate the prognostic significance of miR-423-3p in lung cancer. CCK-8 and Transwell assays were used to determine the functional role of miR-423-3p in lung cancer. Results We observed that miR-423-3p was significantly upregulated in lung cancer tissues and cell lines. Overexpression of miR-423-3p was significantly associated with lymph node metastasis, TNM stage, and poor prognosis. Multivariate Cox regression analysis results showed that miR-423-3p was an independent prognostic indicator for lung cancer patients. Results of functional analyses revealed that overexpression of miR-423-3p promoted cell proliferation, migration, and invasion in lung cancer cells. Conclusions These results indicated that miR-423-3p acts as an oncogene and promotes cell proliferation migration, and invasion of lung cancer. And miR-423-3p may serve as a potential prognostic biomarker and therapeutic target for the treatment of lung cancer.

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“…Furthermore, ligand‐dependent Notch activation required mono‐ubiquitination of cytoplasmic domain of ligands, followed by internalization of ligands to cytoplasm (Itoh et al, 2003; Takeuchi et al, 2005). Indeed, cytoplasmic localization of Notch ligands is frequently found in various cancer cells (He et al, ; Townsend et al, ; Zhang et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…One of Notch ligand, JAG2 appeared to exert several carcinogenesis, endometrial cancer (Townsend et al, ), colorectal cancer. (He et al, ), myeloma.…”

Section: Introductionmentioning

confidence: 99%

Overexpression of JAG2 is related to poor outcomes in oral squamous cell carcinoma

Hatano

Saigo

Kito

et al. 2019

Clinical & Exp Dental Res

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Objectives JAG2 is one of Notch ligands, which recently appear to exert various carcinogenesis. In the present study, we aimed to unveil the relation of JAG2 expression and clinicopathological features in oral squamous cell carcinoma (OSCC). Materials and Methods We examined JAG2 expression in OSCC plus adjacent nontumorous epithelia in eight patients. Ninety‐one OSCC tissue specimens were immunohistochemically stained with specific antibodies to JAG2. The immunoreactivities of JAG2 were correlated with clinicopathological factors, including the prognosis of patients. Chi‐square test, Kaplan–Meier survival, and Cox proportional hazard analysis were used to determine the statistical value of JAG2 expression in OSCC. Results JAG2 mRNA expression was much expressed in OSCC tissues compared with adjacent tissue specimens in five of eight patients. JAG2 immunoreactivity was found at invasion front in 31 of 91 OSCC. JAG2 immunoreactivity was significantly associated with age, less than 50 years old of patients (P = .048). Kaplan–Meier analysis demonstrated that the patients with JAG2 immunoreactvty have a short overall survival. With the Cox proportional hazard regression mode, the independent factors predictive of poor overall survival included JAG2 immunoreactivity (P < .05). Conclusions The present findings suggest that JAG2 overexpression, especially at the cancer invasion front, has potential prognostic value.

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Potential new biomarkers for endometrial cancer

Cited by 44 publications

References 47 publications

Investigating the Role of Telomere and Telomerase Associated Genes and Proteins in Endometrial Cancer

Investigating the Role of Telomere and Telomerase Associated Genes and Proteins in Endometrial Cancer

Overexpression of microRNA-423-3p indicates poor prognosis and promotes cell proliferation, migration, and invasion of lung cancer

Overexpression of JAG2 is related to poor outcomes in oral squamous cell carcinoma

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