Potential of amphiphilically modified low molecular weight chitosan as a novel carrier for hydrophobic anticancer drug: Synthesis, characterization, micellization and cytotoxicity evaluation

Development of Respirable Nanomicelle Carriers for Delivery of Amphotericin B by Jet Nebulization

“…1). 19,22 The CMC values of copolymers with 17% and 60% substitution degree were 2 Â 10 À2 and 2 Â 10 À3 mg/ mL, respectively, which were lower than the CMC of low-molecular weight surfactants 19 and also lower than some chitosan grafted copolymers which were reported previously. 16,22 The results indicated that the CMC value of DC-SA micelles would decrease following increase of substitution degree.…”

“…Similar result was obtained by loading paclitaxel molecules in low molecular weight chitosan-based polymeric micelles. 22 Zeta potential is an important parameter for measuring the stability of polymeric micelles. Amino groups of chitosan are responsible for relatively high positive surface charges for DC-SA micelles, which provided repelling forces among adjacent particles.…”

Self-assembled micelles based on hydrophobically modified quaternized cellulose for drug delivery

“…Nowadays, increasing interest has been focused on the polymer micelles based on hydrophobically modified polysaccharides, because they can not only solubilize and stabilize the hydrophobic drug but also decrease their eventual high toxicity to healthy cells [10,11]. Nevertheless, compared to the numerous works published on conventional block copolymers, the investigations on the self-assembled micelles based on hydrophobically modified polysaccharides as drug delivery systems are still rather limited [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25].…”

Enhanced Oral Absorption of Paclitaxel in N-Deoxycholic Acid-N, O-Hydroxyethyl Chitosan Micellar System

“…21,22 Moreover, grafting hydrophobic and hydrophilic moieties to CS allows it to form micelles in aqueous solution. 23,24 Considering the special structure of micellar system and the absorption enhancing effect of CS, an amphiphilic CS derivative, N-deoxycholic acid-N, O-hydroxyethyl chitosan (DHC), was developed to improve the limited oral bioavailability of PTX. A similar compound hydrophobically modified glycol chitosan (HGC) 25 was reported to encapsulate PTX.…”