Potential of Bacillus licheniformis for the production of 2,3-butanediol

Nilegaonkar, Smita; Bhosale, Suresh B.; Dandage, Chitra N.; Kapadi, A. H.

doi:10.1016/0922-338x(96)89161-6

Cited by 15 publications

(11 citation statements)

References 11 publications

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“…Many bacterial species produce 2,3-butanediol by fermentation, but the best producers seem to be Klebsiella oxytoca [5], Enterobacter aerogenes [6], Bacillus polymyxa [7], and Bacillus licheniformis [8]. …”

Section: Introductionmentioning

confidence: 99%

“…Interest in microbial production of 2,3-butanediol has been increasing recently due to extensive industrial application of this product [ 4 ]. Many bacterial species produce 2,3-butanediol by fermentation, but the best producers seem to be Klebsiella oxytoca [ 5 ], Enterobacter aerogenes [ 6 ], Bacillus polymyxa [ 7 ], and Bacillus licheniformis [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Enhancement of 2,3‐Butanediol Production by Klebsiella oxytoca PTCC 1402

Anvari

Motlagh

2011

BioMed Research International

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Optimal operating parameters of 2,3-Butanediol production using Klebsiella oxytoca under submerged culture conditions are determined by using Taguchi method. The effect of different factors including medium composition, pH, temperature, mixing intensity, and inoculum size on 2,3-butanediol production was analyzed using the Taguchi method in three levels. Based on these analyses the optimum concentrations of glucose, acetic acid, and succinic acid were found to be 6, 0.5, and 1.0 (% w/v), respectively. Furthermore, optimum values for temperature, inoculum size, pH, and the shaking speed were determined as 37°C, 8 (g/L), 6.1, and 150 rpm, respectively. The optimal combinations of factors obtained from the proposed DOE methodology was further validated by conducting fermentation experiments and the obtained results revealed an enhanced 2,3-Butanediol yield of 44%.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhancement of 2,3‐Butanediol Production by Klebsiella oxytoca PTCC 1402

Anvari

Motlagh

2011

BioMed Research International

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“…An optimization study of glucose fermentation by B. licheniformis, likely performed using a factorial experimental design, demonstrated that an increase in the inoculum's size had positive effect on the yield as well (Nilegaonkar et al, 1996).…”

Section: Resultsmentioning

confidence: 99%

Enhancement of 2,3-butanediol production by Klebsiella pneumoniae PTCC 1290: Application of Taguchi methodology for process optimization

Khayati¹,

Pahlevanzadeh²,

Ghaemi³

et al. 2009

Afr. J. Biotechnol.

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2,3-Butanediol production parameter optimization using Klebsiella pneumoniae PTCC 1290 was performed using the design of experiments available in the form of an orthogonal array and a software for automatic design and analysis of the experiments, both based on Taguchi protocol. Optimal levels of physical parameters and key media components namely temperature, pH, inoculum size, agitation, acetic acid and succinic acid were determined. 2,3-Butanediol production obtained from the 18 sets of fermentation experiments performed with the selected factors and levels were further processed with Qualitek-4 software at bigger is better as quality character. The optimized conditions showed an enhanced 2,3-butanediol production of 35.8% (from 11.856 to 18.459 g l -1). The optimal combinations of factors obtained from the proposed design of experiments methodology was further validated by conducting fermentation experiments and the obtained results revealed an enhanced 2,3-butanediol production of 25.8%. Taguchi approach of design of experiments resulted in evaluating the main and interaction effects of the factors individually and in combination.

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“…Bacterial 2,3-BDO production has been shown e.g. with strains of Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter aerogenes, Bacillus polymyxa, and Bacillus licheniformis (Grover et al, 1990, Perego et al, 2000, De Mas et al, 1988, Nilegaonkar et al, 1996, Jansen et al, 1984. Biosynthesis of 2,3-BDO is funneled from pyruvate in three steps.…”

Section: 3-butanediolmentioning

confidence: 99%