Potential of bacterial culture media in biofabrication of metal nanoparticles and the therapeutic potential of the as‐synthesized nanoparticles in conjunction with artemisinin against MDA‐MB‐231 breast cancer cells

Abstract

In the recent past, various groups have proposed diverse biocompatible methods for the synthesis of metal nanoparticles (NPs). Besides culture biomass, culture supernatants (CS) are increasingly being explored for the synthesis of NPs; however, with the ever-increasing exploration of various CS in the biofabrication of NPs, it is equally important to explore the potential of various culture media (CMs) in the synthesis of metal NPs. Considering these aspects, in the present investigation, we explore the possible applicability of various CMs in the biofabrication of metal NPs.The synthesis of NPs was primarily followed by UV/VIS spectroscopy, and, thereafter, the NPs were characterized by various physiochemical techniques, including EM, EDX, FT_IR, X-ray diffraction, and DLS measurements, and finally, their anticancer potentialities were investigated against breast cancer. In addition, the NPs were examined in conjunction with artemisinin for therapeutic benefits against aggressive and highly metastatic MDA-MB-231 breast cancer cells. Cumulatively, the results of the present study collated the potentials of various bacterial CMs in the biofabrication of metal NPs and ascertained the efficacy of the as-synthesized silver nanoparticles, especially the combinatorial entity as intriguing breast cancer therapeutics. The data of the present study plausibly assist in advancing the therapeutic applicability of the combinatorial amalgam against aggressive and highly metastatic MDA-MB-231 breast cancer cells. K E Y W O R D S artemisinin (ART), breast cancer, culture media (CMs), culture supernatants (CS), nanoparticles (NPs)

Applications of Metallic Nanoparticles in the Skin Cancer Treatment

“…The important role of MNPs in the clinical context of cancer treatment is extensive optical properties, high surface-to-volume ratio, easy synthesis and chemistry, and facial surface function [ 59 , 62 , 63 ]. MNPs and metal oxide NPs (MONPs) have effective anticancer activity in various types of cancer, such as breast cancer [ 64 ], lung [ 65 ], colorectal [ 66 ], pancreatic [ 67 ], and skin cancers [ 68 ]. Different MNPs and MONPs have a better cytotoxic efficacy on skin cancer than conventional dosage forms.…”

Potential of Topical Cosmeceuticals Cream Functionalized with Biogenic Metallic Nanostructured Material as Antibacterial Agents

“…A previous study demonstrated that due to compositional difference in cell wall and membrane of Gram-positive and Gram-negative bacteria, silver nanoparticles shows variation in antibacterial activity. Moreover, researchers have suggested that the bonding of Ag + with DNA, leads to fragmentation of DNA [49]. Interaction of silver nanoparticles with cytoplasm, multiple enzymes, transporter proteins, and nucleic has also been reported as a possible mechanism leading to cell death [50].…”

Antineoplastic Efectiveness of Silver Nanoparticles Synthesized from Onopordum Acanthium L. extract (AgNPs-OAL) toward MDA-MB231 Breast Cancer Cells

“…It has been reported that new strategies for targeting ROS contribute to the cancer therapy [23]. Various reports have elucidated the roles of different nanometals in triggering ROS content in different cancer cells [24,25]. Zhu et al reported that AgNPs can induce human hepatocellular carcinoma HepG-2 cell apoptosis via ROSmediated MAPKs, AKT, and p53 signaling pathways [26].…”