Potential of Bioactive Glass Particles of Different Size Ranges to Affect Bone Formation in Interproximal Periodontal Defects in Dogs

Felipe, Maria Emília M.C.; Andrade, Patrícia Freitas de; Novaes, Arthur B.; Grisi, Márcio F. M.; Souza, Sérgio Luı́s Scombatti de; Taba, Mário; Palioto, Daniela Bazan

doi:10.1902/jop.2009.080583

Cited by 17 publications

(18 citation statements)

References 31 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, the SiCaP investigated was identical in composition and manufacture and granule size was the only variable investigated. A study by Felipe et al10 showed distinct dissolution rates for Bioglass of different size ranges. Results from the study reported a statistically significant difference favouring bone growth adjacent to granules 300–355 μm in size when compared with those of 90–710 μm in size.…”

Section: Discussionmentioning

confidence: 99%

“…Granule size is also thought to be important as it has an effect on the rate of resorption and the ability of the material to promote bone growth 8. Previous studies have shown that a minimum space of 100 μm between graft particles is essential to allow for neo‐vascularisation and bone formation and that when the spaces become larger, bone growth increases 9–11. Particle sizes of about 380 μm in diameter will yield this minimal dimension of inter‐particular space 12.…”

Section: Introductionmentioning

confidence: 99%

“…Particle sizes of about 380 μm in diameter will yield this minimal dimension of inter‐particular space 12. A study by Yukna et al11 reported that particle sizes between 300 and 500 μm provided adequate space between the particles and were optimum for the treatment of periodontal bone defects, however a study by Felipe et al10 found that bioglass particles of smaller size range underwent faster resorption and were subsequently replaced by more new bone also shown in canine periodontal defects. Oonishi et al13 evaluated the osteointegration of HA granules of 1–3 μm, 10 μm, and 100–300 μm in diameter and reported that a minimal size of 10 μm was necessary for direct bone contact between bone and the HA granules.…”

Section: Introductionmentioning

confidence: 99%

“…8 Previous studies have shown that a minimum space of 100 lm between graft particles is essential to allow for neo-vascularisation and bone formation and that when the spaces become larger, bone growth increases. [9][10][11] Particle sizes of about 380 lm in diameter will yield this minimal dimension of inter-particular space. 12 A study by Yukna et al 11 reported that particle sizes between 300 and 500 lm provided adequate space between the particles and were optimum for the treatment of periodontal bone defects, however a study by Felipe et al 10…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The effect of particle size on the osteointegration of injectable silicate‐substituted calcium phosphate bone substitute materials

Coathup

Cai²,

Campion³

et al. 2013

J Biomed Mater Res

View full text Add to dashboard Cite

Calcium phosphate (CaP) particles as a carrier in an injectable bone filler allows less invasive treatment of bony defects. The effect of changing granule size within a poloxamer filler on the osteointegration of silicate-substituted calcium phosphate (SiCaP) bone substitute materials was investigated in an ovine critical-sized femoral condyle defect model. Treatment group (TG) 1 consisted of SiCaP granules sized 1000–2000 μm in diameter (100 vol %). TG2 investigated a granule size of 250–500 μm (75 vol %), TG3 a granule size of 90–125 μm (75 vol %) and TG4 a granule size of 90–125 μm (50 vol %). Following a 4 and 8 week in vivo period, bone area, bone-implant contact, and remaining implant area were quantified within each defect. At 4 weeks, significantly increased bone formation was measured in TG2 (13.32% ± 1.38%) when compared with all other groups (p = 0.021 in all cases). Bone in contact with the bone substitute surface was also significantly higher in TG2. At 8 weeks most new bone was associated within defects containing the smallest granule size investigated (at the lower volume) (TG4) (42.78 ± 3.36%) however this group was also associated with higher amounts of fragmented SiCaP. These smaller particles were phagocytosed by macrophages and did not appear to have a negative influence on healing. In conclusion, SiCaP granules of 250–500 μm in size may be a more suitable scaffold when used as an injectable bone filler and may be a convenient method for treating bony defects. © 2013 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 902–910, 2013

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of particle size on the osteointegration of injectable silicate‐substituted calcium phosphate bone substitute materials

Coathup

Cai²,

Campion³

et al. 2013

J Biomed Mater Res

View full text Add to dashboard Cite

show abstract

“…For disinfection purposes, bioactive glasses have shown no side effects in root canal therapy (19) due to several probable mechanisms, including the inhibition of bacterial colonization, a pH increase in aquatic solutions, and calcium levels (25)(26)(27). However, calcium hydroxide indicated a better antimicrobial effect than bioactive glass (28).…”

Section: Introductionmentioning

confidence: 99%

Bactericidal Activity of Copper Oxide Nanocomposite/Bioglass for in Vitro Clindamycin Release in Implant Infections Due to Staphylococcus aureus

Alijanian¹,

Talebian²,

Doudi³

2016

Avicenna J Med Biochem

View full text Add to dashboard Cite

Background: In recent years, bioactive bioceramics such as bioglass and hydroxyapatite (HA) have been introduced as a remarkable development in the field of medicine due to their bio-adaptability, non-toxicity, and persistence, in vivo. They have many potential applications in the repair of bone defects and hence they have attracted significant interest from scholars. Objectives: The aim of this study was to synthesize inorganic matrix CuO-based bioglasses and evaluate their antibacterial activity against aerobic bacterial infections in bone implants. Methods: Nano-composite samples of silica-based bioactive glass, 60S BG with nano-powder CuO, were synthesized using the sol-gel method and then assessed with regard to their antibacterial properties against Staphylococcus aureus using well diffusion agar. The samples included BG58S (58%SiO2, 36%CaO, 6%P2O5), BG/10CuO (58%SiO2, 26%CaO, 6%P2O5, 10%CuO), and BG/20CuO (48%SiO2, 26%CaO, 6%P2O5, 20%CuO). To evaluate their bioactivity, the prepared samples of BG/20CuO, BG/10CuO, and BG58S were immersed in simulated body fluids (SBF). The surface morphology and structure of the samples before and after immersion in the SBF were characterized using scanning electron microscopy (SEM) and Fourier transform infrared (FTIR), respectively. Then, the BG/20CuO and BG/10CuO samples were loaded in clindamycin, an antibiotic widely used in the treatment of osteomyelitis, and their release profiles were studied in phosphate buffer solution. Results: It was observed that the growth inhibition zone increased through clindamycin release due to the increasing CuO percentage in the nanocomposite of bioactive glass. The bioactivity of the nanocomposite/bioglass with CuO was superior to that of bioglass alone. In this study, the BG/20CuO sample showed a sustained release of clindamycin, which is sufficient for a drug delivery system. Conclusions: Increasing the Cu nanoparticles in bioactive glass samples leads to the release of Cu 2+ , which has a positive effect on the antibacterial mechanism, as well as decreasing the cultured Staphylococcus colonies found on the bioglasses. Therefore, it seems that the nanocomposite/bioglass of CuO is a promising option for aerobic bacterial inhibitor systems in common bone implant infections.

show abstract

Bioactive glass in the treatment of an infrabony defect in a dog

Bilgiç¹

2023

Vet Record Case Reports

View full text Add to dashboard Cite

This article describes a graft‐only approach to regenerate periodontal structures in a vertical infrabony defect around the mesial root of the mandibular second molar tooth of a dog. Bioactive glass material was used to fill this defect without coverage of a membrane. The grafted area was examined using periodontal probing and an intraoral radiograph 6 months after the procedure. Probing depth around the affected root had decreased to normal levels, and the intraoral radiograph of the affected area revealed new bone growth. Bioactive glass without a membrane appeared to be sufficient for alveolar bone regeneration in this canine patient.

show abstract

Potential of Bioactive Glass Particles of Different Size Ranges to Affect Bone Formation in Interproximal Periodontal Defects in Dogs

Abstract: The bioactive glass particles of small size range underwent faster resorption and substitution by new bone than the larger particles, and the use of bioactive glass particles favored the formation of mineralized bone.

Cited by 17 publications

References 31 publications

The effect of particle size on the osteointegration of injectable silicate‐substituted calcium phosphate bone substitute materials

The effect of particle size on the osteointegration of injectable silicate‐substituted calcium phosphate bone substitute materials

Bactericidal Activity of Copper Oxide Nanocomposite/Bioglass for in Vitro Clindamycin Release in Implant Infections Due to Staphylococcus aureus

Bioactive glass in the treatment of an infrabony defect in a dog

Contact Info

Product

Resources

About