Potential of C-Phenylcalix[4]Resorcinarene Epoxide Compound as Drug Delivery Agent in Breast Cancer Cells MCF-7

Fatmawati, Dwi Rahmasari; Hidayat, Danny Nur Wahyu; Sari, Diah Kartika; Putri, Rizky Riyami; Jumina, Jumina; Kurniawan, Yehezkiel Steven

doi:10.14710/jksa.25.3.123-129

Cited by 4 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Efforts to reduce the side effects caused by the active ingredients of drugs that are more selective and effective in cancer treatment are needed (Fatmawati et al, 2022). Modern computational chemistry approaches using molecular docking methods can simulate how compounds interact with target proteins and predict the chemical characteristics required for drug activity (Widiyarti, Firdayani, et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Hybridization Synthesis and Anticancer Activity Test of New Carboxylic Acid Derivatives by In-Silico and In-Vitro

Azhar,

Warsito,

Srihardyastutie

2023

jppipa, pendidikan ipa, fisika, biologi, kimia

View full text Add to dashboard Cite

Design of new compounds as active ingredients of drugs must be selective and efficient to achieve therapeutic efficacy and minimize resulting side effects. Hybridization synthesis approaches using major components of essential oils can reliably generate new molecules that are superior as active ingredients of anti-cancer drugs due to their cytotoxic properties. This study synthesized a hybrid molecule of citronellyl salicylate by an esterification reaction using Steglich and Fisher method under ultrasonic assistance. The Steglich esterification is more efficient in producing citronellyl salicylate during 30 minutes reaction, yield 12.45%. Analysis of the synthesized product by FTIR is characterized by the presence of typical absorptions of the ester group at ῡ 1650 cm-1 and 1270 cm-1, while LC ESI-MS shows m/z 294 is indicated [M+NH4]+. Anticancer activity was tested in-silico for protein receptors MMP-9, MMP-2, Cyclin-A, p53, and BAK using Molecular Docking Pyrx 9.0 and the highest activity was shown binding affinity value -8.4 kcal/mol for the MMP-9 protein receptor. Similarly, the results of the in vitro activity assay of citronellyl salicylate to 4T1 breast cancer cells showed that the morphology of cancer cells was damaged and the viability of cancer cells was lower than that of normal cells

show abstract

Section: Introductionmentioning

confidence: 99%

Hybridization Synthesis and Anticancer Activity Test of New Carboxylic Acid Derivatives by In-Silico and In-Vitro

Azhar,

Warsito,

Srihardyastutie

2023

jppipa, pendidikan ipa, fisika, biologi, kimia

View full text Add to dashboard Cite

show abstract

Oliveramine: An Isolated Alkaloid from Fagraea fragrans (Tembesu) Bark

et al. 2022

View full text Add to dashboard Cite

This paper described the progress of phytochemical, especially alkaloids, work on Fagraea fragrans species (tembesu), Loganiaceae. A dimeric-pyridine alkaloid with molecular formula C20H20O4N2 has been successfully isolated from diethyl ether extracts from this plant’s barks. The alkaloid was explored from diethyl ether extracts using sulphuric acid (2%), then basified with ammonium hydroxide (25%) until the solution had a pH of 10.5. The later solution was extracted again with chloroform. The alkaloid residue was subjected to column chromatography and eluted with 10% acetone in chloroform. The chemical structure of the isolated dimeric-pyridine alkaloid was determined by LCMS/MS, 13C-NMR, and 1H-NMR spectroscopies. As a result, the isolated dimeric-pyridine alkaloid was closely similar to the oliveramine alkaloid, and this is also the first report about oliveramine from Fagraea fragrans (F. Fragrans).

show abstract

The Journey of Natural Products: From Isolation Stage to Drug’s Approval in Clinical Trials

Kurniawan,

Indriani,

Amrulloh

et al. 2023

Bioactivities

View full text Add to dashboard Cite

Nature serves as an excellent inspiration for researchers in the fields of chemistry and medicine. Terrestrial or marine organisms produce billions of natural products with unique chemical and physical properties. Some of them have been used in traditional therapy for specific diseases since ancient times. Although their exact chemical structures have yet to be elucidated clearly in that time, investigations in medicinal chemistry have been well documented. Furthermore, utilizing natural products in drug design and development offers advantages such as high biocompatibility, low toxicity, fewer side effects, wide bioactivities, and large structure diversity. Nowadays, rational drug research using computer-aided drug design is well established to cut the long way of drug discovery and overcome the resistance cases and the increment in the number of active patients. This review will highlight some natural products to comprehensively understand their journey from unknown natural products, isolation, purification, characterization, in silico evaluation, bioactivity screening assay, drug modifications, in vitro investigation, in vivo examination, and clinical trial.

show abstract

Potential of C-Phenylcalix[4]Resorcinarene Epoxide Compound as Drug Delivery Agent in Breast Cancer Cells MCF-7

Cited by 4 publications

References 20 publications

Hybridization Synthesis and Anticancer Activity Test of New Carboxylic Acid Derivatives by In-Silico and In-Vitro

Hybridization Synthesis and Anticancer Activity Test of New Carboxylic Acid Derivatives by In-Silico and In-Vitro

Oliveramine: An Isolated Alkaloid from Fagraea fragrans (Tembesu) Bark

The Journey of Natural Products: From Isolation Stage to Drug’s Approval in Clinical Trials

Contact Info

Product

Resources

About