Potential of costimulation-based therapies for composite tissue allotransplantation

Elster, Eric A.; Blair, Patrick J.; Kirk, Allan D.

doi:10.1002/1098-2752(2000)20:8<430::aid-micr14>3.0.co;2-k

Cited by 26 publications

(7 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of "co-stimulatory blockade" to prevent allograft rejection was presented by Elster et al [53]. Fundamentally, activated recipient T-cells cause rejection.…”

Section: Current Status Of Ctamentioning

confidence: 99%

Composite Tissue Allotransplantation (CTA): Current Status and Future Insights

et al. 2001

View full text Add to dashboard Cite

Approximately 7 million individuals (over 1 million amputees) require complex reconstructive procedures in the United States each year. The recent success of clinical composite tissue allotransplantation, attests to the fact that composite tissue allografts have tremendous potential in these life-enhancing reconstructions.This review summarizes the initial outcomes of the first four human hand transplants, together with those of the first larynx, bone, knee, nerve and tendon transplants, with special emphasis on the operative technique, graft survival and functional outcomes. The May 2000 Louisville symposium, where these results were presented was undoubtedly a milestone in the history of modern composite tissue allotransplantation. It set the stage for reconstructive and transplant surgeons, researchers, physiotherapists, patients and patient advocates and members of the community to convene and discuss major advances in current composite tissue allotransplantation. The symposium underscored the vital importance of objective evaluation of the status of composite tissue allotransplantation by frank dissemination of details of clinical results and complications of the transplants performed thus far.The composite tissue allotransplantation area is among the newest of transplant areas. The immunology of composite tissue allografts is complex, making tolerance more difficult to achieve than organ tolerance. It needs to be emphasized that any episodes of acute rejection should be prevented for perfect restoration of function and to minimize the risk of chronic rejection in composite tissue allografts. Efficacious, safe and ethical clinical tolerance protocols could improve patient acceptance of composite tissue allografts by providing an alternative to chronic immunosuppression.

show abstract

“…The use of "co-stimulatory blockade" to prevent allograft rejection was presented by Elster et al [53]. Fundamentally, activated recipient T-cells cause rejection.…”

Section: Current Status Of Ctamentioning

confidence: 99%

Composite Tissue Allotransplantation (CTA): Current Status and Future Insights

et al. 2001

View full text Add to dashboard Cite

show abstract

“…This has not been achieved so far. However, when a protocol for the induction of tolerance becomes a clinical reality, composite tissue allografts would certainly become a therapeutic option for multiple indications in a greater number of patients (Bu¨ttemeyer et al, 1996;Elster et al, 2000;Gorantla et al, 2003;Hettiaratchy, 2004;Hewitt, 1998;Jones, 2002;Kann and Hewitt, 2001;Llull, 1998;Orloff et al, 1995;Ozer et al, 2003;Rossini et al, 1999;Thomas et al, 2000;Werkele et al, 1998). There are several potential pathways towards what has been called the ''holy grail'' in transplantation.…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Hand Transplantation: The State-of-the-Art

Schuind¹,

Abramowicz

Schneeberger

2007

J Hand Surg Eur Vol

View full text Add to dashboard Cite

The feasibility of hand transplantation has been demonstrated, both surgically and immunologically. Levels of immunosuppression comparable to regimens used in solid organ transplantation are proving sufficient to prevent graft loss. Many patients have achieved discriminative sensibility and recovery of intrinsic muscle function. In addition to restoration of function, hand transplantation offers considerable psychological benefits. The recipient's pre-operative psychological status, his motivation and his compliance with the intense rehabilitation programme are key issues. While the induction of graft specific tolerance represents a hope for the future, immunosuppression currently remains necessary and carries significant risks. Hand transplantation should, therefore, only be considered a therapeutic option for a carefully selected group of patients.

show abstract

“…105 Moreover, it is important to consider the prothrombotic properties of anti-CD154 mAb because they will limit its use in a field where graft survival depends on the microvascular anastomosis. 106,107 Clearly, further studies should be done to clarify the benefits of mAbs in the tolerance of CTA.…”

Section: Blockage Of Costimulatory Molecules (Blockage Of the Second mentioning

confidence: 99%