2021
DOI: 10.3390/pharmaceutics13060818
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Potential of Cyanine Derived Dyes in Photodynamic Therapy

Abstract: Photodynamic therapy (PDT) is a method of cancer treatment that leads to the disintegration of cancer cells and has developed significantly in recent years. The clinically used photosensitizers are primarily porphyrin, which absorbs light in the red spectrum and their absorbance maxima are relatively short. This review presents group of compounds and their derivatives that are considered to be potential photosensitizers in PDT. Cyanine dyes are compounds that typically absorb light in the visible to near-infra… Show more

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Cited by 86 publications
(57 citation statements)
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“…Finally, the accuracy of target tissue irradiation is the most important point when considering PDT as a treatment option. Therefore, deep tumors (not easily accessible without surgical intervention) are difficult to treat due to the low penetration of visible light into the tissue [ 54 , 56 ]. The main advantages and limitations of PDT are summarized in Table 3 .…”
Section: Advantages and Limitations Of Pdtmentioning
confidence: 99%
“…Finally, the accuracy of target tissue irradiation is the most important point when considering PDT as a treatment option. Therefore, deep tumors (not easily accessible without surgical intervention) are difficult to treat due to the low penetration of visible light into the tissue [ 54 , 56 ]. The main advantages and limitations of PDT are summarized in Table 3 .…”
Section: Advantages and Limitations Of Pdtmentioning
confidence: 99%
“…First of all, their absorption maxima can be tuned to the NIR region through easy structural modifications. Moreover, their biocompatibility, low toxicity and good photostability make them suitable for biological applications and in particular for photodynamic therapy [6,33,[55][56][57][58].…”
Section: Cyanine Dye-based Photosensitizersmentioning
confidence: 99%
“…For this reason, porphyrins and related compounds , are the most widely studied photosensitizers, with some examples having reached clinical use for photodynamic therapy (PDT) . Other classes of photosensitizer include the fluorones, , azadipyrromethenes, , metal coordination complexes, , and cyanine dyes, although of these only a few candidates have so far received approval for use in humans. , …”
Section: Introductionmentioning
confidence: 99%