Potential of Health and Demographic Surveillance System in Asthma and Chronic Obstructive Pulmonary Disease Microbiome Research

Dhotre, Dhiraj; Patil, Rutuja; Shouche, Yogesh S.; Juvekar, Sanjay; Salvi, Sundeep

doi:10.3389/fpubh.2017.00196

Cited by 5 publications

(3 citation statements)

References 62 publications

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“…China has a high incidence of COPD, and with an increasing population, environment deterioration and prominent aging problem, the number of COPD patients complicated with pneumonia has also shown a growing trend ( 9 ). Alveolar lavage using antibiotics based on the bronchoscope technique has been widely applied in clinic to remove the lung mucus and control inflammation, which can effectively increase the treatment effective rate of COPD patients complicated with pneumonia, and reduce the inflammatory response ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

Analysis of curative effect of adjuvant therapy with bronchoalveolar lavage on COPD patients complicated with pneumonia

Zhao

Liu

et al. 2018

Exp Ther Med

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Clinical effect of adjuvant therapy with bronchoalveolar lavage on chronic obstructive pulmonary disease (COPD) patients complicated with pneumonia and its influence on the expression levels of inflammatory factors were studied. One hundred and twenty mild-moderate COPD patients complicated with pneumonia treated in the Department of Respiratory Medicine, The Sixth People's Hospital of Nantong from February 2016 to February 2017 were selected and randomly divided into three groups: One-time lavage group (n=40), two-time lavage group (n=40) and control group (n=40). Fasting peripheral blood was collected from all the patients in the morning. The lung function and blood gas analyses, and the detection of peripheral white blood cells (WBC), procalcitonin (PCT) and C-reactive protein (CRP) were performed. Moreover, the messenger RNA (mRNA) levels of interleukin-6 (IL-6), IL-8, tumor necrosis factor-α (TNF-α) and leukotriene B4 (LTB4) in lavage fluid were detected via reverse transcription-quantitative polymerase chain reaction. The lung functions of patients in the two-time lavage group were significantly improved compared with that in the one-time lavage group (p<0.01). pH and PaO2 in two-time lavage group were higher than those in the one-time lavage group (p<0.01). Peripheral WBC, PCT and CRP levels in the two-time lavage group were lower than those in the one-time lavage group (p<0.05). The mRNA levels of IL-6, IL-8, TNF-α and LTB4 in lavage fluid in two-time lavage group were lower than those in one-time lavage group (p<0.01). IL-6, IL-8, TNF-α and LTB4 expression levels in lavage fluid in two-time lavage group were lower than those in one-time lavage group (p<0.01). In conclusion, the adjuvant therapy with bronchoalveolar lavage improves the therapeutic effect on COPD patients complicated with pneumonia, which can significantly reduce the expression levels of inflammatory factors, and facilitate the control of pulmonary infection and recovery of lung function.

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Section: Discussionmentioning

confidence: 99%

Analysis of curative effect of adjuvant therapy with bronchoalveolar lavage on COPD patients complicated with pneumonia

Zhao

Liu

et al. 2018

Exp Ther Med

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“…e supplementation of these genera in nude mice can reduce the number of pulmonary eosinophils, reduce the immune response of 1/ 2 or 17 [34][35][36], and alleviate the symptoms of those abovementioned respiratory diseases [37][38][39]. Notably, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pneumoniae, and Klebsiella pneumoniae were found to be the most common bacterial species in patients with severe respiratory diseases, which were also considered to be the potential pathogenic factors [40][41][42]. (2) e pulmonary epithelial barrier dysfunction impacts the removal mechanism for lung microorganisms (e.g., damaged mucosa cilia) or promotes the migration of microorganisms to the lungs (e.g., secondary infections).…”

Section: Lung Microbiota and Respiratorymentioning

confidence: 99%

Gut-Lung Microbiota in Chronic Pulmonary Diseases: Evolution, Pathogenesis, and Therapeutics

Shi

et al. 2021

Canadian Journal of Infectious Diseases and Medical Microbiolog

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The microbiota colonized in the human body has a symbiotic relationship with human body and forms a different microecosystem, which affects human immunity, metabolism, endocrine, and other physiological processes. The imbalance of microbiota is usually linked to the aberrant immune responses and inflammation, which eventually promotes the occurrence and development of respiratory diseases. Patients with chronic respiratory diseases, including asthma, COPD, bronchiectasis, and idiopathic pulmonary fibrosis, often have alteration of the composition and function of intestinal and lung microbiota. Gut microbiota affects respiratory immunity and barrier function through the lung-gut microbiota, resulting in altered prognosis of chronic respiratory diseases. In turn, lung dysbiosis promotes aggravation of lung diseases and causes intestinal dysfunction through persistent activation of lymphoid cells in the body. Recent advances in next-generation sequencing technology have disclosed the pivotal roles of lung-gut microbiota in the pathogenesis of chronic respiratory diseases. This review focuses on the association between the gut-lung dysbiosis and respiratory diseases pathogenesis. In addition, potential therapeutic modalities, such as probiotics and fecal microbiota transplantation, are also evaluated for the prevention of chronic respiratory diseases.

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“…Various types of CB-MISs have been used for different public health purposes, such as demographic surveillance, disease surveillance, vaccine safety assessments, epidemiological research, and clinical trials. [1][2][3][4][5][6] Few studies in the peer-reviewed literature assess the contributions that a CB-MIS can make to the planning, monitoring, and evaluation of social and behavior change communication (SBCC) interventions. This article describes the effectiveness of the CORE Group Polio Project (CGPP) program to improve polio and routine immunization (RI) coverage in underserved populations, the contribution of its CB-MIS to achieving these results, the strength of the vital events registration system embodied within the CB-MIS, and the potential of this CB-MIS for contributing to the effectiveness of other public health programs in similar environments.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of a Census-Based Management Information System for Guiding Polio Eradication and Routine Immunization Activities: Evidence from the CORE Group Polio Project in Uttar Pradesh, India

Choudhary

Perry

Solomon

2019

The American Journal of Tropical Medicine and Hygiene

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Census-based management information systems (CB-MISs) bring strength and power to public health programs by providing current information about everyone in the population covered by the program. Such a system has been developed by the CORE Group Polio Project (CGPP) in India. This article assesses the effectiveness of the CGPP CB-MIS in the management of social and behavioral change interventions. It also assesses the feasibility of the CB-MIS for vital events registration. We describe the procedures of the CB-MIS and measure the outcomes of the CGPP by observing the trends of vaccination coverage in CGPP catchment areas over time. We also compute vital statistics from births and deaths registered through the CGPP CB-MIS and compare them with the estimates from the Civil Registration System of India using statistics from India's Sample Registration System in Uttar Pradesh as the "gold standard." The CB-MIS has helped the CGPP to manage its social and behavior change communication interventions effectively, and it has contributed to the increase in polio vaccine coverage facilitated by the CGPP. We also estimate that the CGPP's CB-MIS has registered 86% of births and 98% of infant deaths, a much higher level of registration than has been achieved by the Civil Registration System for the entire state of Uttar Pradesh. The CB-MIS has helped to make it possible for community-based health workers to make behavioral diagnoses of barriers to immunization and to overcome them. The CB-MIS also provides a robust platform for community-based health workers to register vital events.

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Potential of Health and Demographic Surveillance System in Asthma and Chronic Obstructive Pulmonary Disease Microbiome Research

Cited by 5 publications

References 62 publications

Analysis of curative effect of adjuvant therapy with bronchoalveolar lavage on COPD patients complicated with pneumonia

Analysis of curative effect of adjuvant therapy with bronchoalveolar lavage on COPD patients complicated with pneumonia

Gut-Lung Microbiota in Chronic Pulmonary Diseases: Evolution, Pathogenesis, and Therapeutics

Effectiveness of a Census-Based Management Information System for Guiding Polio Eradication and Routine Immunization Activities: Evidence from the CORE Group Polio Project in Uttar Pradesh, India

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