2021
DOI: 10.3390/ijms22179178
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Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration

Abstract: Age-related macular degeneration (AMD) is the leading cause of visual impairment in the aging population with poorly known pathogenesis and lack of effective treatment. Age and family history are the strongest AMD risk factors, and several loci were identified to contribute to AMD. Recently, also the epigenetic profile was associated with AMD, and some long non-coding RNAs (lncRNAs) were shown to involve in AMD pathogenesis. The Vax2os1/2 (ventral anterior homeobox 2 opposite strand isoform 1) lncRNAs may modu… Show more

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Cited by 16 publications
(6 citation statements)
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References 106 publications
(124 reference statements)
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“…97 Overexpression of PWRN2, a Prader-Willi region non-protein-coding RNA 2, has been associated with in age-related macular degeneration. 98 MARCHF10 is a E3 ubiquitin-protein ligase, a class of molecules implicated in memory formation, recovery from stroke and several neurological diseases. 99 We replicated our VaD signals using EADB data (Table 3).…”
Section: Discussionmentioning
confidence: 99%
“…97 Overexpression of PWRN2, a Prader-Willi region non-protein-coding RNA 2, has been associated with in age-related macular degeneration. 98 MARCHF10 is a E3 ubiquitin-protein ligase, a class of molecules implicated in memory formation, recovery from stroke and several neurological diseases. 99 We replicated our VaD signals using EADB data (Table 3).…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, most transcripts cannot be translated into proteins which are de ned as ncRNAs. The ncRNAs contain various lncRNAs and miRNAs with a length of more than 200nt [23] and 22nt [24] , respectively.…”
Section: Discussionmentioning
confidence: 99%
“…The fundamental function of lncRNAs is the regulation of gene expression that can be performed directly or indirectly in cis or trans. lncRNAs may form base pairs with a complementary fragment of mRNA, impeding its translation—the antisense function [ 115 ]. lncRNAs recruit and/or guide transcription factors to regulate the transcription of the target gene—the guide function.…”
Section: Epigenetic Connections Of Cgrpmentioning
confidence: 99%