2016
DOI: 10.1016/j.arabjc.2014.09.009
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Potential of N-aryl(benzyl,heteryl)-2-(tetrazolo[1,5-c]quinazolin-5-ylthio)acetamides as anticancer and antimicrobial agents

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Cited by 20 publications
(12 citation statements)
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“…Substances 1.1–1.5 were synthesized according to the reported procedures [ 10 , 11 ]. Other starting materials and solvents were obtained from commercially available sources and used without additional purification.…”
Section: Methodsmentioning
confidence: 99%
“…Substances 1.1–1.5 were synthesized according to the reported procedures [ 10 , 11 ]. Other starting materials and solvents were obtained from commercially available sources and used without additional purification.…”
Section: Methodsmentioning
confidence: 99%
“…Besides, the inhibition of protein kinase CK2 was established as one of the possible mechanisms of the detected antitumor activity. 59 In papers of Antypenko et al 57,58 it was shown, that S-substituted tetrazolo[1,5-c]quinazoline-5(6H)-thiones 142-144 exhibit anticancer, antimicrobial, and antifungal activity. Thus, 1-(4-methoxyphenyl)-2-(tetrazolo [1,5-c]quinazolin-5-ylsulfanyl)ethanones, 5-(3-chloropropylsulfanyl) tetrazolo [1,5-c]quinazolines inhibited growth of C. albicans, 5-[2-(N,N-dialkylaminoethyl)sulfanyl]tetrazolo[1,5-c]-quinazolines did it in respect to S. aureus and E. faecalis.…”
Section: Biological Properties Of 2-(azolyl)anilinesmentioning
confidence: 99%
“…55,57,58 The high levels of growth inhibition served as a cytotoxicity marker of potential possession of the antitumor activity. It was shown, that tetrazolyl-and ([1,2,4]-triazol-3-yl)anilines their condensed derivatives (compounds 62, 137-139, 142-144) possess antitumor activity against 60 human cancer cell lines.…”
Section: Biological Properties Of 2-(azolyl)anilinesmentioning
confidence: 99%
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“…9,10 Our latest investigations of substituted condensed tetrazolo [1,5-c]quinazolines have also proved their potential as pharmaceutical agents, namely anticancer (N-(benzo[d]thiazol-2-yl)-2-(tetrazolo [1,5-c]quinazolin-5-ylthio)acetamides against cells of melanoma), antimicrobial (1-(2,5-dimethoxyphenyl)-2-(tetrazolo [1,5-c]quinazolin-5-ylthio)ethanone against Staphylococcus aureus), antifungal (5-(3-chloropropylthio)tetrazolo [1,5-c]quinazoline against Candida albicans), and bioluminescence inhibition properties. 11,12 So, tetrazolo [1,5-c]quinazolines are of undoubting interest and valuable objects for further research. In this work, as a logical continuation of our previous investigations a range of 6-N-R-tetrazolo [1,5- …”
Section: Introductionmentioning
confidence: 99%