Potential of nanoemulsions for accelerated wound healing: innovative strategies

Abstract

Wounds represent various significant health concerns for patients and also contribute major costs to healthcare systems. Wound healing comprises of overlapped and various coordinated steps such as homeostasis, inflammation, proliferation, and remodeling. In response to the failure of many strategies in delivering intended results including wound closure, fluid loss control, and exhibiting properties such as durability, targeted delivery, accelerated action, along with histocompatibility, numerous nanotechnological advances have been introduced. To understand the magnitude of wound therapy, this systematic and updated review discussing the effectiveness of nanoemulsions has been undertaken. This review portrays mechanisms associated with wound healing, factors for delayed wound healing, and various technologies utilized to treat wounds effectively. While many strategies are available, nanoemulsions have attracted the tremendous attention of scientists globally for the research in wound therapy due to their long-term thermodynamic stability and bioavailability. Nanoemulsions not only aid in tissue repair, but are also considered as an excellent delivery system for various synthetic and natural actives. Nanotechnology provides several pivotal benefits in wound healing, including improved skin permeation, controlled release, and stimulation of fibroblast cell proliferation. The significant role of nanoemulsions in improved wound healing along with their preparation techniques has also been highlighted with special emphasis on mechanistic insights. This article illustrates recent research advancements for the utilization of nanoemulsions in wound treatment. An adequate literature search has been conducted using the keywords ‘Nanoemulsions in wound healing’, ‘Wound therapy and nanoemulsions’, ‘Herbal actives in wound therapy’, ‘Natural oils and wounds treatment’ etc., from PubMed, Science Direct, and Google Scholar databases. Referred and original publications in the English language accessed till April 2022 has been included, whereas nonEnglish language papers, unpublished data, and nonoriginal papers were excluded from the study.

Nanomaterials in the Wound Healing Process: New Insights and Advancements

“…Over the last two decades, the use of nanomaterials (NMs), specifically novel formulations such as nanoparticles formulated for wound healing processes and infection management, has expanded dramatically [ 9 ]. The scaffolding of nanoparticles for wound healing has recently gained a lot of attention as a targeted approach to advanced dressings [ 10 ]. Antimicrobial NMs currently come in a range of forms, including polymers such as lipids in liposomes, cellulose, and mesoporous silica, which serve as carriers for antimicrobial and wound healing agents ( Figure 1 ) [ 11 ].…”

Accelerating Diabetic Wound Healing by Modulating the Inflammatory Environment Using Quercetin–Rosemary Oil Lipid Nanoemulsions with Artificial Intelligence‐Based Wound Closure Analysis

“…Recent advances in nanotechnology have led to the development of lipid‐based nanoemulsions as promising platforms for delivering drugs and bioactive compounds to target tissues. [ 24–28 ]…”

“…Recent advances in nanotechnology have led to the development of lipid-based nanoemulsions as promising platforms for delivering drugs and bioactive compounds to target tissues. [24][25][26][27][28] Achieving accurate delineation of wound regions from medical images is paramount for effective diagnosis and treatment planning. In this approach.…”

The wound healing effect of polycaprolactone-chitosan scaffold coated with a gel containing Zataria multiflora Boiss. volatile oil nanoemulsions

“…Additionally, regarding the great potential of nanoemulsion formulations in drug delivery, their application in preparing novel scaffolds could be promising [ 56 , 57 ]. Meanwhile, considering the desirable properties of hydroxypropyl methylcellulose (HPMC), such as safety, hydrophilic nature of gel matrix, and excellent skin biocompatibility, it can be considered as a good candidate for preparing nanoemulsion formulation [ 58 – 61 ].…”