Potential of neem ( Azadirachta indica L.) for prevention and treatment of oncologic diseases

Patel, Shradha M.; Venkata, Kalyan C. Nagulapalli; Bhattacharyya, Piyali; Sethi, Gautam; Bishayee, Anupam

doi:10.1016/j.semcancer.2016.03.002

Cited by 165 publications

(121 citation statements)

References 74 publications

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“…Azadirachta indica (Neem) is the most useful traditional medicinal plant and considered as "Village dispensary" in India. Twigs of the neem (datoon) are used by a significant portion of the population to maintain oral hygiene [7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Topical Application of <i>Azadirachta indica</i> (Neem) in Prevention of Gingivitis: A Randomized Control Trial

Singh¹,

Pathak²,

Goel³

et al. 2019

OJST

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Background: The purpose of the present study was to envisage the anti-plaque and anti-inflammatory properties of neem (Azadirachta) in the form of a mouth gel. Materials and Methods: A total of 60 subjects (33 males and 27 females) from age group 19 -35 years, suffering from mild to moderate gingivitis were randomly divided into two groups. Group A (n = 30) participants were advised experimental (neem) gel and Group B (n = 30) participants were advised 0.2% chlorhexidine gel. All the clinical parameters (the gingival index by Loe and Silness [1], Plaque index by Silness and Loe [2] and sulcus bleeding index by Muhlemann H. R. and Sen S. [3]) were recorded at baseline, on the 14 th day and 21 st day by the same clinician in both groups. Results: on intragroup comparison the gingival index, plaque index and sulcus bleeding index decrease significantly in both the groups in all assessed periods. On intergroup comparison the indices did not differ significantly at baseline but after 2 nd and 3 rd week, the indices in Group B decrease more than the group A, which was statistically significant. Conclusion: Based on the observations of our study, it can be concluded that chlorhexidine gluconate as well as neem gel can be effectively used as an adjunct to mechanical plaque control in prevention of plaque and gingivitis. chlorhexidine gluconate gel has been found to be more effective when antiplaque and anti-inflammatory properties were considered. The effect of neem observed maybe because of its anti-inflammatory action. The antiplaque action of chlorhexidine gluconate is due to its substantivity. Substantivity of neem is required to be further studied.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Topical Application of <i>Azadirachta indica</i> (Neem) in Prevention of Gingivitis: A Randomized Control Trial

Singh¹,

Pathak²,

Goel³

et al. 2019

OJST

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“…Aerial parts and seeds of the neem tree ( Azadirachta indica ) have been used as traditional medicine to treat a number of human disease conditions . Neem has a rich use in Ayurvedic traditional medicine, and its folkloric use to treat pro‐inflammatory conditions has led to the hypothesis that its anti‐inflammatory potential could be useful in cancer prevention and treatment . Supporting this notion is the long history of traditional use of neem to treat acute and chronic inflammatory disease in India and Africa .…”

Section: Introductionmentioning

confidence: 99%

“…1 Neem has a rich use in Ayurvedic traditional medicine, and its folkloric use to treat pro-inflammatory conditions has led to the hypothesis that its anti-inflammatory potential could be useful in cancer prevention and treatment. 2 Supporting this notion is the long history of traditional use of neem to treat acute and chronic inflammatory disease in India and Africa. 3 Neem twigs, for instance, have long been used traditionally to maintain oral health and neem has been shown to have anti-bacterial, anti-fungal, and anti-ulcer properties.…”

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confidence: 99%

A supercritical CO₂ extract of neem leaf (A. indica) and its bioactive liminoid, nimbolide, suppresses colon cancer in preclinical models by modulating pro‐inflammatory pathways

Patel

Tripathy

Mukhopadhyay

et al. 2018

Molecular Carcinogenesis

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Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer death in men and women in the United States. Anti-inflammatory blockade has been proven to be a promising avenue of colorectal cancer prevention. However, NSAIDs while effective in curbing CRC risk are too toxic for long-term use in cancer prevention. The Neem tree (Azadirachta indica) is rich in liminoid terpenoids, collectively known as azadiractoids and has been shown to have anti-inflammatory effects. To explore a role of neem in CRC, human colon cancer cell lines HCT116 and HT29 cells were treated with purified Super Critical Neem Extract (SCNE) or the neem liminoid, nimbolide. SCNE treatment resulted in a dose dependent inhibition of CRC cell proliferation and an increase in apoptosis. Treatment with SCNE and nimbolide decreased the expression of transcriptional factors, STAT3 and NF-κB which plays a major role in gene regulation of multiple cellular processes. Protein expression of COX1, IL-6, and TNF-α were decreased on treatment with SCNE in CRC cells. Western blots and Zymogram assays results revealed anti-invasive effect by decreased expression of MMP2 and MMP9 proteins in CRC cells. Overall, these data confirm a potential anti-cancer effect of SCNE, reducing cell proliferation, inflammation, migration, and invasion in human colon cancer cells. Confirming these indications, we found that treatment of mice bearing HT29 and HCT116 xenografted tumors exhibited striking inhibition of colon tumor growth. Clearly we must explore the effect of neem in preclinical animal models for anti-cancer therapy.

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“…Azadirachta indica A. Juss has a good control effect on S. litura as a plant pesticide, and because of the chemical effects of azadirachta compounds, considerable progress has been made in their biological activities and pharmaceutical applications in the past 50 years. It is now considered a valuable source of unique natural products (Patel, Nagulapalli Venkata, Bhattacharyya, Sethi, & Bishayee, 2016). Previous research has shown that azadirachtin has a variety of biological effects on insects, such as antifeeding (Tomé et al, 2013), inhibition of growth and development (Lucantoni et al, 2006), avoidance (Bezzar-Bendjazia, Kilani-Morakchi, Maroua, & Aribi, 2017;Liu & Liu, 2006), cytotoxicity (Radhika, Sahayaraj, Senthil-Nathan, & Hunter, 2018), and so on.…”

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confidence: 99%

Antifeeding effects of azadirachtin on the fifth instar Spodoptera litura larvae and the analysis of azadirachtin on target sensilla around mouthparts

Qin

Zhang

You

et al. 2019

Arch Insect Biochem Physiol

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To clarify the types, number, and distribution of sensilla on the head of the fifth instar Spodoptera litura (Fabricius) (Lepidoptera: Noctuidae) larvae and identify the main sensilla of azadirachtin acting on larvae, scanning electron microscopy was used to study the morphology of the head and sensilla on the mouthparts. The four sensilla—sensillum basiconicum, sensillum chaeticum, sensillum styloconicum, and sensillum trichodeum—on the head of the fifth instar larvae were treated with 0, 0.1, 0.5, 1, 2, and 4 mg/kg azadirachtin by a microdrop method. The larvae showed an obvious antifeeding effect with azadirachtin. And higher the concentration of azadirachtin, the more obvious the phenomenon of antifeeding activity. The sensillum styloconicum and the sensillum trichodeum were the main sensilla for azadirachtin. When 1 mg/kg azadirachtin was used to treat sensillum styloconicum and sensillum basiconicum, the fifth instar larvae of S. litura showed obvious antifeedant activity and the cumulative feed intake for 24 hr was no more than 30% of the leaf area. Quantitative reverse‐transcription polymerase chain reaction verified the expression patterns of some Grs, indicating that Grst43a was upregulated by 1.3‐ and 3.9‐fold, Gor24 was upregulated by 2.5‐ and 3.3‐fold, Gr5a was downregulated by 0.6‐fold and upregulated by 2.0‐fold, and Gr28a was downregulated by 0.8‐fold and upregulated by 3.6‐fold upon treatment with 0.5 mg/kg and 1 mg/kg azadirachtin in 24 hr. Gr genes participated in the identification of bitterness and we speculated that Gr genes may indirectly lead to the occurrence of antifeeding behavior.

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Potential of neem ( Azadirachta indica L.) for prevention and treatment of oncologic diseases

Cited by 165 publications

References 74 publications

Evaluation of Topical Application of <i>Azadirachta indica</i> (Neem) in Prevention of Gingivitis: A Randomized Control Trial

Evaluation of Topical Application of <i>Azadirachta indica</i> (Neem) in Prevention of Gingivitis: A Randomized Control Trial

A supercritical CO₂ extract of neem leaf (A. indica) and its bioactive liminoid, nimbolide, suppresses colon cancer in preclinical models by modulating pro‐inflammatory pathways

Antifeeding effects of azadirachtin on the fifth instar Spodoptera litura larvae and the analysis of azadirachtin on target sensilla around mouthparts

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Potential of neem ( Azadirachta indica L.) for prevention and treatment of oncologic diseases

Cited by 165 publications

References 74 publications

Evaluation of Topical Application of &lt;i&gt;Azadirachta indica&lt;/i&gt; (Neem) in Prevention of Gingivitis: A Randomized Control Trial

Evaluation of Topical Application of &lt;i&gt;Azadirachta indica&lt;/i&gt; (Neem) in Prevention of Gingivitis: A Randomized Control Trial

A supercritical CO2 extract of neem leaf (A. indica) and its bioactive liminoid, nimbolide, suppresses colon cancer in preclinical models by modulating pro‐inflammatory pathways

Antifeeding effects of azadirachtin on the fifth instar Spodoptera litura larvae and the analysis of azadirachtin on target sensilla around mouthparts

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Evaluation of Topical Application of <i>Azadirachta indica</i> (Neem) in Prevention of Gingivitis: A Randomized Control Trial

Evaluation of Topical Application of <i>Azadirachta indica</i> (Neem) in Prevention of Gingivitis: A Randomized Control Trial

A supercritical CO₂ extract of neem leaf (A. indica) and its bioactive liminoid, nimbolide, suppresses colon cancer in preclinical models by modulating pro‐inflammatory pathways