Potential of Superhydrophobic Surface for Blood-Contacting Medical Devices

Wu, Xun Hui; Liew, Yun Khoon; Wu, Chun; Then, Yoon Yee

doi:10.3390/ijms22073341

Cited by 41 publications

(20 citation statements)

References 94 publications

(120 reference statements)

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“…For instance, implantable medical devices, such as metal mesh-based heart stents, covered stents, cardiac occluders, etc. can be developed considering superhydrophobic surfaces have been preliminarily demonstrated with blood-repellent properties for anticoagulation and antithrombus [30][31][32]. In addition, superhydrophobic SSM has been widely used for metal corrosion protection and oil-water separation [33].…”

Section: Preparation Of Durable Superhydrophobic Ssm/pdms-cs Surfacesmentioning

confidence: 99%

Highly durable superhydrophobic surfaces based on a protective frame and crosslinked PDMS-candle soot coatings

Sun

Lou

et al. 2022

Mater. Res. Express

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Superhydrophobic surfaces can be applied to environmental, energy, and healthcare fields. However, the weak durability issue has significantly limited the practical industrial applications. To overcome the readily destroyed interfacial structures and chemical compositions, the superhydrophobic surfaces with high mechanical and chemical durability have been created on a stainless steel mesh (SSM) as a protective frame based on tightly crosslinked polydimethylsiloxane (PDMS)−candle soot (CS) composite coatings through simple mechanical transfer and candle burning processes, which abbreviated to SSM/PDMS−CS and showed a water contact angle (WCA) of 159.4 ± 1.6° and a sliding angle (SA) of 2.3 ± 0.5°. Harsh abrasion examinations based on sandpaper and fiber paper have been conducted by applying 100 g weight and 200 cm sliding distance. And the obtained WCAs and SAs were 155 ± 3.7°, 155.7 ± 2° and 3.7 ± 0.5°, 3.5 ± 0.3°. Scanning electron microscope showed scratches on the surface, but the superhydrophobic property has been well maintained. After 40 kHz ultrasonication treatment for 30 min, WCA and SA were 152 ± 0.9° and 4.1 ± 0.8°. Finally, SSM/PDMS−CS surfaces exhibit good chemical resistance to corrosive solutions even after pH 2, pH 10, 1 M NaCl, and toluene treatments for 15 days.

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Section: Preparation Of Durable Superhydrophobic Ssm/pdms-cs Surfacesmentioning

confidence: 99%

Highly durable superhydrophobic surfaces based on a protective frame and crosslinked PDMS-candle soot coatings

Sun

Lou

et al. 2022

Mater. Res. Express

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“…The application of superhydrophobicity and patterned devices to the biological field is broad and still growing. Superhydrophobic coatings with antibacterial, antiviral, and antimicrobial properties have been reported [ 146 , 147 ], as well as nanostructured devices for cells and platelets adhesion or repellence [ 148 ], cell culture, tissue engineering, drug delivery [ 149 ], biosensing [ 150 , 151 ], and proteins analysis [ 152 ].…”

Section: Smart Substrates For Nucleic Acids Characterizationmentioning

confidence: 99%

DNA Studies: Latest Spectroscopic and Structural Approaches

et al. 2021

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This review looks at the different approaches, techniques, and materials devoted to DNA studies. In the past few decades, DNA nanotechnology, micro-fabrication, imaging, and spectroscopies have been tailored and combined for a broad range of medical-oriented applications. The continuous advancements in miniaturization of the devices, as well as the continuous need to study biological material structures and interactions, down to single molecules, have increase the interdisciplinarity of emerging technologies. In the following paragraphs, we will focus on recent sensing approaches, with a particular effort attributed to cutting-edge techniques for structural and mechanical studies of nucleic acids.

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“…However, those coatings certified for clinical application today are only efficient to delay the undesired blood-surface interaction. Novel approaches such as coating with superhydrophobic [ 13 , 14 ], omniphobic [ 15 ] and further molecules are still the subject of current research and development [ 16 , 17 ] and have not entered the clinical arena yet.…”

Section: Introductionmentioning

confidence: 99%

Towards Biohybrid Lung: Induced Pluripotent Stem Cell Derived Endothelial Cells as Clinically Relevant Cell Source for Biologization

et al. 2021

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In order to provide an alternative treatment option to lung transplantation for patients with end-stage lung disease, we aim for the development of an implantable biohybrid lung (BHL), based on hollow fiber membrane (HFM) technology used in extracorporeal membrane oxygenators. Complete hemocompatibility of all blood contacting surfaces is crucial for long-lasting BHL durability and can be achieved by their endothelialization. Autologous endothelial cells (ECs) would be the ideal cell source, but their limited proliferation potential excludes them for this purpose. As induced pluripotent stem cell-derived ECs enable the generation of a large number of ECs, we assessed and compared their capacity to form a viable and confluent monolayer on HFM, while indicating physiologic EC-specific anti-thrombogenic and anti-inflammatory properties. ECs were generated from three different human iPSC lines, and seeded onto fibronectin-coated poly-4-methyl-1-pentene (PMP) HFM. Following phenotypical characterization, ECs were analyzed for their thrombogenic and inflammatory behavior with or without TNFα induction, using FACS and qRT-PCR. Complementary, leukocyte- and platelet adhesion assays were carried out. The capacity of the iPSC-ECs to reendothelialize cell-free monolayer areas was assessed in a scratch assay. ECs sourced from umbilical cord blood (hCBECs) were used as control. iPSC-derived ECs formed confluent monolayers on the HFM and showed the typical EC-phenotype by expression of VE-cadherin and collagen-IV. A low protein and gene expression level of E-selectin and tissue factor was detected for all iPSC-ECs and the hCBECs, while a strong upregulation of these markers was noted upon stimulation with TNFα. This was in line with the physiological and strong induction of leukocyte adhesion detected after treatment with TNFα, iPSC-EC and hCBEC monolayers were capable of reducing thrombocyte adhesion and repopulating scratched areas. iPSCs offer the possibility to provide patient-specific ECs in abundant numbers needed to cover all blood contacting surfaces of the BHL with a viable, non-thrombogenic and non-inflammatory monolayer. iPSC-EC clones can differ in terms of their reendothelialization rate, and pro-inflammatory response. However, a less profound inflammatory response may even be advantageous for BHL application. With the proven ability of the seeded iPSC-ECs to reduce thrombocyte adhesion, we expect that thrombotic events that could lead to BHL occlusion can be avoided, and thus, justifies further studies on enabling BHL long-term application.

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Potential of Superhydrophobic Surface for Blood-Contacting Medical Devices

Cited by 41 publications

References 94 publications

Highly durable superhydrophobic surfaces based on a protective frame and crosslinked PDMS-candle soot coatings

Highly durable superhydrophobic surfaces based on a protective frame and crosslinked PDMS-candle soot coatings

DNA Studies: Latest Spectroscopic and Structural Approaches

Towards Biohybrid Lung: Induced Pluripotent Stem Cell Derived Endothelial Cells as Clinically Relevant Cell Source for Biologization

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