Potential of the aqueous extract of Terminalia chebula as an anticaries agent

Jagtap, Aarti; Karkera, S.G

doi:10.1016/s0378-8741(99)00058-6

Cited by 82 publications

(71 citation statements)

References 7 publications

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“…The extract was prepared according to Jagtap et al, [17] with slight modification. The dried ripe fruit of T. chebula was obtained and ground into a fine powder.…”

Section: Preparation Of the Extractmentioning

confidence: 99%

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Anti Cariogenic Effect of Terminalia Chebula

Rekha

Jayamathi

Ramakrishnan

et al. 2014

JCDR

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Background: Terminalia chebula is one of the traditional medicines used in the treatment of many diseases and possesses a wide variety of therapeutic activities. The aim of this study was to determine the antimicrobial properties of Terminalia chebula against oral pathogens related to caries. Materials and Methods:In this study, Antimicrobial activity was tested using Kirby bouer method by streaking. Total phenol and total flavonoid content were analysed. Twenty high caries risk patients were subjected to rinse aqueous extract of Terminalia chebula. Salivary samples were collected for pH and microbial screening. Oral pathogens were identified by qualitative biochemical analysis. Results:The total phenol content of extract was found to be 21.33 ±1.633 (mean ± SD) and total flavonoids was found to be 23.17 ± 2.317 (mean ± SD). There was a gradual increase in pH till 45mts post-rinse when compared to pre-rinse was observed. Antimicrobial effect of Terminalia Chebula aganist microbes showed that there was a significant reduction between the prerinse and post-rinse samples.Conclusion: These promising findings suggested the presence of antimicrobial activity of Terminalia Chebula against oral pathogens and proven to be an effective alternate antimicrobial agent.

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“…The extract was prepared according to Jagtap et al, [17] with slight modification. The dried ripe fruit of T. chebula was obtained and ground into a fine powder.…”

Section: Preparation Of the Extractmentioning

confidence: 99%

“…The dried extract thus obtained was exposed to UV rays for 24h and checked for sterility on nutrient agar plates and stored in labelled sterile bottles in a freezer at 4°C until further use. This concentrate was then diluted with sterile distilled water to get a mouth rinse of 10% (w/v) concentration [17].…”

Section: Preparation Of the Extractmentioning

confidence: 99%

Anti Cariogenic Effect of Terminalia Chebula

Rekha

Jayamathi

Ramakrishnan

et al. 2014

JCDR

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“…5 However, only three studies have assessed the effect of aqueous extract of Terminalia chebula on Streptococcus mutans. [6][7][8] But, none of the studies conducted till now have assessed the effect of ethanol extract of Terminalia chebula on Streptococcus mutans. Since in vitro studies are the preliminary studies done to establish the efficacy of any antibacterial agent, an in vitro study was conducted with an aim of determining the effect of Terminalia chebula extract prepared using two different solvents, on Streptococcus mutans.…”

Section: Introductionmentioning

confidence: 99%

“…6,7 The difference could be due to the variation in the fruit used in the studies or variation in the extraction preparation procedures. The MIC of ethanolic extract in the present study was 2.5%.…”

mentioning

confidence: 99%

An in vitro Study to determine the Effect of Terminalia chebula Extract and Its Formulation on Streptococcus mutans

Nayak

Ankola

Metgud

et al. 2014

The Journal of Contemporary Dental Practice

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Aim: Many weapons are available in the arsenal of a dental professional to combat dental caries, which is almost ubiquitously present. From a public health perspective, most of these weapons are far from being an ideal drug. Hence, there is a demand for better and effective antibacterial agents. This factor stimulated the process of the present study. The aim of the study was to determine the effect of ethanol extract of Terminalia chebula on Streptococcus mutans. Materials and methods:Dried ripe fruits of Terminalia chebula were procured and powdered. Physical tests were done to estimate purity of the fruit powder. Hydroethanolic and aqueous extracts were prepared according to standard procedures. Minimum inhibitory concentration of the extracts was determined by tube dilution method and confirmed by agar dilution method. The effect of the hydroethanolic extract on sucrose induced adhesion, glucan-induced aggregation and on glycolysis of Streptococcus mutans was also assessed. Preservative, gelling agent and sweetener were added in suitable quantities to the ethanol extract, and mouthrinse was formulated. Minimum inhibitory concentration of the formulation was also determined. Results:Yield was better in case of aqueous extract. The Minimum inhibitory concentration of hydroethanolic extract was determined to be 2.5%. Minimum inhibitory concentration of the aqueous extract was determined to be 10%. Hydroethanolic extract of Terminalia chebula (2.5%) inhibited sucrose induced adherence and aggregation of Streptococcus mutans in vitro. Conclusion:The mouthrinse formulated from ethanol extract of Terminalia chebula demonstrated substantial antibacterial activity and could be used as an effective anticaries agent. Clinical Significance: Terminalia chebula mouthrinse can be effectively used in clinical practice as an anticaries mouthrinse with additional benefit being that it is safe and economical. Original research

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“…Acacia arabica 10 is considered as an astringent and credited with the antimicrobial activity. Triphala acts as anticaries agents strongly inhibits the sucrose or glucan induced aggregations of S. Mutans 11 and strengthens the gums, prevents and treats several diseases of mouth such as dental caries, spongy and bleeding gums, gingivitis and stomatitis 12 . The strong antioxidant activity of Triphala may be partially responsible for many of the biological properties 13 .…”

Section: Herbal Extracts Include the Following Agentsmentioning

confidence: 99%