Potential Pharmacotherapy of Alzheimer Disease. A Comparison of Various Forms of Physostigmine Administration

Becker, Robert E.; Giacobini, Ezio; Elble, R.; McIlhany, Michael; Sherman, Kathleen

doi:10.1111/j.1600-0404.1988.tb07983.x

Cited by 41 publications

(21 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The acetylcholine concentration in the brain of AD patients appears to be a critical element in the development of dementia [25]. Loss of cholinergic cells, particularly in the basal forebrain, is accompanied by loss of the neurotransmitter acetylcholine [25,26]. One approach is to inactivate AChE, the enzyme that 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 13 one was identified as an AChE mixed-type inhibitor, and molecular docking studies suggested that it was most likely to bind to the active site and the peripheral anionic site of ChE [29].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II)

Hung

Lee

Chuong

et al. 2015

Chemico-Biological Interactions

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II)

Hung

Lee

Chuong

et al. 2015

Chemico-Biological Interactions

View full text Add to dashboard Cite

“…Loss of cholinergic cells, particularly in the basal forebrain, is accompanied by loss of the neurotransmitter acetylcholine (Selkoe, 1994). A decrease in acetylcholine in the brains of patients with AD appears to be a critical element in producing dementia (Becker et al , 1988). In chronic dementia, re-uptake of acetylcholine decreases in neurons of the frontal cortex and hippocampus, and changes in increasing AChE activity occur.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Eucommia ulmoides Oliv. Bark on Scopolamine-Induced Learning and Memory Deficits in Mice

Kwon

Joo

et al. 2013

Biomolecules and Therapeutics

View full text Add to dashboard Cite

Eucommia ulmoides Oliv. Bark (EUE) is commonly used for the treatment of hypertension, rheumatoid arthritis, lumbago, and ischialgia as well as to promote longevity. In this study, we tested the effects of EUE aqueous extract in graded doses to protect and enhance cognition in scopolamine-induced learning and memory impairments in mice. EUE significantly improved the impairment of short-term or working memory induced by scopolamine in the Y-maze and significantly reversed learning and memory deficits in mice as measured by the passive avoidance and Morris water maze tests. One day after the last trial session of the Morris water maze test (probe trial session), EUE dramatically increased the latency time in the target quadrant in a dose-dependent manner. Furthermore, EUE significantly inhibited acetylcholinesterase (AChE) and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus and frontal cortex in a dose-dependent manner. EUE also markedly increased brain-derived neurotrophic factor (BDNF) and phosphorylation of cAMP element binding protein (CREB) in the hippocampus of scopolamine-induced mice. Based on these findings, we suggest that EUE may be useful for the treatment of cognitive deficits, and that the beneficial effects of EUE are mediated, in part, by cholinergic signaling enhancement and/or protection.

show abstract

“…Acetylcholinesterase inhibitors (AChEIs) currently form the basis of the newest drugs available for the management of this disease. AChEIs are general chemical classes, such as physostigmine, galanthamine, tacrine and heptylphysostigmine, and have been tested for the symptomatic treatment of AD (Becker et al, 1988;Fulton and Benfield, 1996). However, the nonselectivity of these drugs, and their limited efficacy, poor bioavailability, adverse cholinergic side effects in the periphery, narrow therapeutic ranges and hepatotoxicity are some of the severe limitations to their therapeutic success (Bores et al, 1996;Forette et al, 1999).…”

Section: Introductionmentioning

confidence: 97%

Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay

et al. 2009

View full text Add to dashboard Cite

Acetylcholinesterase inhibitors (AChEIs) currently form the basis of the newest drugs available for the treatment of Alzheimer's disease. For the aim of screening effective AChEIs, the methanol extracts of the seeds of genus Peganum were found to show significant inhibitory activity of acetylcholinesterase enzyme (AChE) using an in vitro TLC-bioautographic assay. In further studies to seed of P. nigellastrum Bunge, activity-guided fractionation led to the isolation of two new alkaloids nigellastrine I (9) and nigellastrine II (10), and along with eight known alkaloids, vasicinone (1), vasicine (2), harmine (3), deoxyvasicinone (4), deoxyvasicine (5), harmaline (6), harmol (7), harman (8), in which harmol and harman were first isolated from species P. nigellastrum Bunge. As active constituents, all compounds showed good inhibitory activities against AChE. The results of in vitro semi-quality TLC-bioautographic assay showed that harmine, harmaline and harmol displayed a similar AChE inhibitive activities comparing to galanthamine. These results indicated that these alkaloids in P. nigellastrum Bunge could be a potent class of AChEIs.

show abstract

Potential Pharmacotherapy of Alzheimer Disease. A Comparison of Various Forms of Physostigmine Administration

Cited by 41 publications

References 49 publications

Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II)

Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II)

Inhibitory Effects of Eucommia ulmoides Oliv. Bark on Scopolamine-Induced Learning and Memory Deficits in Mice

Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay

Contact Info

Product

Resources

About