Potential plasma microRNAs signature miR-190b-5p, miR-215-5p and miR-527 as non-invasive biomarkers for prostate cancer

Khan, Mohd Mabood; Serajuddin, Mohammad; Bharadwaj, Mausumi

doi:10.1080/1354750x.2022.2163694

Cited by 8 publications

(4 citation statements)

References 74 publications

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“…The most interesting finding of this study was the possibility that plasma miRNAs can serve as circulating biomarkers for PCa because they carry remarkable signatures of the carcinoma. Significant amounts of circulating miRNAs have been detected in a number of biological fluids, indicating their utility as diagnostic markers for a range of physiopathological diseases, including PCa [ 26 , 27 ]. Because of their ability to detect pathological changes early and with high accuracy, their low sensitivity to background noise, and their lack of invasiveness, circulating miRNAs serve as an excellent biomarker [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Integrated grade-wise profiling analysis reveals potential plasma miR-373-3p as prognostic indicator in Prostate Cancer & its target KPNA2

Khan,

Sharma,

Serajuddin

et al. 2024

Non-coding RNA Research

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Section: Discussionmentioning

confidence: 99%

Integrated grade-wise profiling analysis reveals potential plasma miR-373-3p as prognostic indicator in Prostate Cancer & its target KPNA2

Khan,

Sharma,

Serajuddin

et al. 2024

Non-coding RNA Research

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“…Different types of cancer, including PCa, have been shown to have different miRNA expression patterns between tumor and normal tissues, plasma, and exosomes [12,13]. In PCa, various studies have demonstrated that miRNAs regulate numerous cellular and molecular mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of miR-148a-3p and miR-106a-5p as Biomarkers for Prostate Cancer: Pilot Study

Coman,

Schitcu,

Budisan

et al. 2024

Genes

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MicroRNAs (miRNAs) are a class of small non-coding RNAs that may function as tumor suppressors or oncogenes. Alteration of their expression levels has been linked to a range of human malignancies, including cancer. The objective of this investigation is to assess the relative expression levels of certain miRNAs to distinguish between prostate cancer (PCa) from benign prostatic hyperplasia (BPH). Blood plasma was collected from 66 patients diagnosed with BPH and 58 patients with PCa. Real-time PCR technology was used to evaluate the relative expression among the two groups for miR-106a-5p and miR-148a-3p. The significant downregulation of both miRNAs in plasma from PCa versus BPH patients suggests their potential utility as diagnostic biomarkers for distinguishing between these conditions. The concurrent utilization of these two miRNAs slightly enhanced the sensitivity for discrimination among the two analyzed groups, as shown in ROC curve analysis. Further validation of these miRNAs in larger patient cohorts and across different stages of PCa may strengthen their candidacy as clinically relevant biomarkers for diagnosis and prognosis.

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“…Long noncoding RNAs (lncRNAs), exceeding 200 nucleotides, and microRNAs (miR-NAs), typically around 21 nucleotides, represent two distinct types of noncoding RNAs (ncRNAs) devoid of protein-coding capacity [18,19]. These ncRNA variants play pivotal roles in governing gene transcription and translation by interacting with the 3' untranslated region (3'UTR) of messenger RNA (mRNA) [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Long Noncoding RNA MALAT1: Salt-Sensitive Hypertension

Khan,

Kirabo

2024

IJMS

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Hypertension stands as the leading global cause of mortality, affecting one billion individuals and serving as a crucial risk indicator for cardiovascular morbidity and mortality. Elevated salt intake triggers inflammation and hypertension by activating antigen-presenting cells (APCs). We found that one of the primary reasons behind this pro-inflammatory response is the epithelial sodium channel (ENaC), responsible for transporting sodium ions into APCs and the activation of NADPH oxidase, leading to increased oxidative stress. Oxidative stress increases lipid peroxidation and the formation of pro-inflammatory isolevuglandins (IsoLG). Long noncoding RNAs (lncRNAs) play a crucial role in regulating gene expression, and MALAT1, broadly expressed across cell types, including blood vessels and inflammatory cells, is also associated with inflammation regulation. In hypertension, the decreased transcriptional activity of nuclear factor erythroid 2-related factor 2 (Nrf2 or Nfe2l2) correlates with heightened oxidative stress in APCs and impaired control of various antioxidant genes. Kelch-like ECH-associated protein 1 (Keap1), an intracellular inhibitor of Nrf2, exhibits elevated levels of hypertension. Sodium, through an increase in Sp1 transcription factor binding at its promoter, upregulates MALAT1 expression. Silencing MALAT1 inhibits sodium-induced Keap1 upregulation, facilitating the nuclear translocation of Nrf2 and subsequent antioxidant gene transcription. Thus, MALAT1, acting via the Keap1-Nrf2 pathway, modulates antioxidant defense in hypertension. This review explores the potential role of the lncRNA MALAT1 in controlling the Keap1-Nrf2-antioxidant defense pathway in salt-induced hypertension. The inhibition of MALAT1 holds therapeutic potential for the progression of salt-induced hypertension and cardiovascular disease (CVD).

show abstract

Potential plasma microRNAs signature miR-190b-5p, miR-215-5p and miR-527 as non-invasive biomarkers for prostate cancer

Cited by 8 publications

References 74 publications

Integrated grade-wise profiling analysis reveals potential plasma miR-373-3p as prognostic indicator in Prostate Cancer & its target KPNA2

Integrated grade-wise profiling analysis reveals potential plasma miR-373-3p as prognostic indicator in Prostate Cancer & its target KPNA2

Evaluation of miR-148a-3p and miR-106a-5p as Biomarkers for Prostate Cancer: Pilot Study

Long Noncoding RNA MALAT1: Salt-Sensitive Hypertension

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