Potential Role of Disrupted Lacrimal Acinar Cells in Dry Eye during Pregnancy

Schechter, Joel; Pidgeon, Michael; Chang, Donald C.; Fong, Yi-Ching; Trousdale, Melvin D.; Chang, Natalie

doi:10.1007/978-1-4615-0717-8_20

Cited by 34 publications

(18 citation statements)

References 5 publications

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“…Dryness can be further increased by dehydration resulting from nausea and vomiting and the use of anti-nausea medications. 7 …”

Section: Physiological Ocular Changesmentioning

confidence: 99%

Pregnancy and the Eye

Yenerel¹,

Küçümen²

2015

tjo

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Pregnancy causes significant changes in all systems of the body. Although most of them are physiological, they may also lead to pathological consequences. The resulting pathological changes may occur for the first time or existing diseases affected by pregnancy can become more serious or change course. Diseases specific only to pregnancy may arise. Like all systems of the body, the visual system is also affected by pregnancy, developing a wide range of physiological and pathological changes. Knowing the ocular physiological changes and diagnosing eye diseases that may develop during pregnancy, and preventing and treating these diseases is crucial to ensure the baby’s healthy development. Therefore, we have reviewed the conditions that an ophthalmologist should recognize, follow-up, and pay attention to during treatment and summarized them under the topic “pregnancy and the eye”.

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“…Dryness can be further increased by dehydration resulting from nausea and vomiting and the use of anti-nausea medications. 7 …”

Section: Physiological Ocular Changesmentioning

confidence: 99%

Pregnancy and the Eye

Yenerel¹,

Küçümen²

2015

tjo

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“…[5] This may occur as a result of the direct disruption of lacrimal acinar cells through pregnancy enhanced immune-reactivity of prolactin, transforming growth factor beta 1, and epidermal growth factor in ductal cells. [56]…”

Section: Physiologic Changesmentioning

confidence: 99%

The eye and visual system in pregnancy, what to expect? An in-depth review

Samra¹

2013

Oman J Ophthalmol

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Pregnancy represents a real challenge to all body systems. Physiological changes can involve any of the body organs including the eye and visual system. The ocular effect of pregnancy involves a wide spectrum of physiologic and pathologic changes. The latter might be presenting for the first time during pregnancy such as corneal melting and corneal ectasia, or an already existing ocular pathologies that are modified by pregnancy such as diabetic retinopathy and glaucoma. In addition, pregnancy can affect vision through systemic disease that are either specific to the pregnant state itself such as the pre-eclampsia/eclampsia and Sheehan's syndrome, or systemic diseases that occur more frequently in relation to pregnancy such as Graves’ disease, idiopathic intracranial hypertension, anti-phospholipid syndrome, and disseminated intravascular coagulation.

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“…10,30,41,42 In pregnant rabbits, LG undergoes an immunophysiological transformation similar to that of the mammary gland as it prepares to deliver milk-prolactin immunoreactivity in the ductal cell increases and redistributes from the apical to basolateral cytoplasm. 43,44 Other reports also showed that lymphocytes in the rabbit LG redistribute from their normal periductal foci to the interacinar space during pregnancy. 15,43 …”

Section: Discussionmentioning

confidence: 95%

Na⁺/K⁺-ATPase Expression Changes in the Rabbit Lacrimal Glands During Pregnancy

Huang¹,

Lu²,

Ding³

2012

Current Eye Research

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Purpose To investigate the expressional changes of Na+/K+-ATPase subunits in the lacrimal glands (LG) of term pregnant rabbits. Methods LG were obtained from term pregnant rabbits and age-matched female control rabbits for laser capture microdissection (LCM), real time RT-PCR, western blot, and immunofluorescence. The mRNA and proteins of α1, α2, β1, β2, and β3 subunits of Na+/K+-ATPase were detected and quantified. Results Although only the mRNA for β3 from whole LG of pregnant rabbits was significantly different from that of normal controls, many mRNA levels for α1, α2, β1, β2, and β3 from acini and epithelial cells from various duct segments that were collected by LCM were significantly different from those of normal control rabbits. Western blots demonstrated that the expressions of all three β subunits were significantly higher in pregnant rabbits, while both α subunits remained unchanged during pregnancy. Interestingly, immunofluorescence results showed that the distribution patterns of all Na+/K+-ATPase subunits during pregnancy were similar to those of the control rabbits. Conclusions Changes were found in mRNA and protein expressions of Na+/K+-ATPase subunits in LG from term pregnant rabbits and these changes suggest a role in the pregnancy-related LG secretion changes and dry eye symptoms observed in these animals.

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Potential Role of Disrupted Lacrimal Acinar Cells in Dry Eye during Pregnancy

Cited by 34 publications

References 5 publications

Pregnancy and the Eye

Pregnancy and the Eye

The eye and visual system in pregnancy, what to expect? An in-depth review

Na⁺/K⁺-ATPase Expression Changes in the Rabbit Lacrimal Glands During Pregnancy

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Potential Role of Disrupted Lacrimal Acinar Cells in Dry Eye during Pregnancy

Cited by 34 publications

References 5 publications

Pregnancy and the Eye

Pregnancy and the Eye

The eye and visual system in pregnancy, what to expect? An in-depth review

Na+/K+-ATPase Expression Changes in the Rabbit Lacrimal Glands During Pregnancy

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Na⁺/K⁺-ATPase Expression Changes in the Rabbit Lacrimal Glands During Pregnancy