Potential role of green tea extract and epigallocatechin gallate in preventing bisphenol A-induced metabolic disorders in rats: Biochemical and molecular evidence

Mohsenzadeh, Mahdieh Sadat; Razavi, Bibi Marjan; Imenshahidi, Mohsen; Yazdi, Seyed Abbas Tabatabaee; Mohajeri, Seyed Ahmad; Hosseinzadeh, Hossein

doi:10.1016/j.phymed.2021.153754

Cited by 11 publications

(7 citation statements)

References 111 publications

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“…In addition, as one of endocrine disrupting chemicals, long‐term exposure to BPA could cause reproductive toxicity, neurotoxicity, immune damage, and metabolic diseases 6–8 . It has been demonstrated in our previous study that exposure to BPA could significantly promote depletion of reduced glutathione (GSH), 9 while affecting lipid metabolism to induce lipid peroxide accumulation, 10 which was consistent with the study by Mohsenzadeh et al 11 At the same time, studies have shown that BPA‐induced inflammation and oxidative stress can promote the occurrence of liver fibrosis, which is a major factor leading to liver failure 12 . So far, discovering effective therapeutic strategies to inhibit BPA‐induced hepatotoxicity is still an urgent issue.…”

Section: Introductionsupporting

confidence: 90%

Hepatoprotective effect of Artemisia Argyi essential oil on bisphenol A‐induced hepatotoxicity via inhibition of ferroptosis in mice

Cui

Zhou

Zhang

et al. 2023

Environmental Toxicology

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The environmental pollutant bisphenol A (BPA), used in the manufacture of plastic packaging materials for various diets, is widely distributed in the environment and causes severe hepatotoxicity by inducing oxidative stress. Artemisia argyi essential oil (AAEO), a volatile oil component isolated from Artemisia argyi H.Lév. & Vaniot, has pharmacological effects, especially for hepatoprotective actions. However, the potential effect of AAEO in BPA induced hepatotoxicity has not been characterized. First, we analyzed the chemical composition in AAEO by gas chromatography–mass spectrometry. Herein, we investigated the effect of AAEO on hepatic metabolic changes in mice exposed to BPA. Results showed that compared with the BPA group, AAEO could reduce the level of liver function enzymes in BPA mice serum, and ameliorate hepatic lesions and fibrosis. Additionally, 20 differential metabolites screened by metabolomics were mainly involved in the reprogramming of glutathione metabolism, purine metabolism, and polyunsaturated fatty acid synthesis. Moreover, AAEO could reduce hepatic ferroptosis induced by BPA, as demonstrated by reducing xanthine oxidase activity, up‐regulating the activities of glutathione peroxidase 4 (GPX4), superoxide dismutase, and catalase and the expression of SLC7A11 to promote the glutathione synthetic, while inhibiting transferrin receptor 1 (TFR1) expression to reduce the accumulation of Fe2+ in cells. Therefore, our study identified AAEO as a hepatic protectant against BPA‐induced hepatotoxicity by reversing the occurrence of ferroptosis.

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Section: Introductionsupporting

confidence: 90%

Hepatoprotective effect of Artemisia Argyi essential oil on bisphenol A‐induced hepatotoxicity via inhibition of ferroptosis in mice

Cui

Zhou

Zhang

et al. 2023

Environmental Toxicology

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“…One possibility is the positive regulation of insulin signaling by flavonoids (da Costa et al, 2017), which might enhance adiponectin secretion (Chen et al, 2016a). Second, several flavonoids have been reported to possess anti‐adipogenic and lipogenic activities, regulating leptin and adiponectin secretion (Danielewski et al, 2021; Du et al, 2021; Mohsenzadeh et al, 2021; Peng et al, 2021; Tan et al, 2021). Additionally, inhibition of oxidative stress (Kowalska, Dembczynski, Golabek, Olkowicz, & Olejnik, 2021) and regulation of gut microbiota (Zhao et al, 2017) by flavonoids might also play a role for its effects on leptin and adiponection level.…”

Section: Discussionmentioning

confidence: 99%

“…Flavonoids are natural products that exist ubiquitously in fruits and vegetables and can be classified into six subgroups, namely, flavonols, flavones, flavanones, isoflavones, flavan3‐ols, and anthocyanosides (Al‐Ishaq, Abotaleb, Kubatka, Kajo, & Busselberg, 2019). Mounting evidence at the cellular and animal level suggests that flavonoid supplementation can increase adiponectin production (Danielewski et al, 2021; Du, Wang, Li, Ren, & Yang, 2021; Mohsenzadeh et al, 2021) or decrease leptin concentration (Peng et al, 2021; Tan et al, 2021). Therefore, the use of fruits and vegetables might be promising for preventing obesity and its associated metabolic diseases by regulating adiponectin/leptin.…”

Section: Introductionmentioning

confidence: 99%

Effect of flavonoid intake on circulating levels of adiponectin and leptin: A systematic review and meta‐analysis of randomized controlled clinical trials

Liu

Zhou

et al. 2022

Phytotherapy Research

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This meta-analysis of randomized controlled trials (RCTs) was conducted to explore the effects of flavonoid intake on adiponectin and leptin levels. The PubMed, EMBASE, and Cochrane Library databases were searched on March 1, 2021. Random-effects, subgroup, sensitivity, and meta-regression analyses were conducted on 40 publications. Flavonoid intake significantly increased circulating adiponectin (0.54 μg/ml, 95% CI [0.20, 0.88], p = .002; I 2 = 86.4%) and significantly reduced leptin levels (weighted mean difference: À0.79 ng/ml, 95% CI [À1.33, À0.25], p = .004; I 2 = 87.7%). Subgroup analysis demonstrated that flavonoid intervention produced a significant elevation in adiponectin levels only in studies that lasted more than 12 weeks, conducted in Asian regions, were parallel-designed, involved obese or overweight participants and participants with type 2 diabetes mellitus (T2DM) or cardiovascular diseases, used tea catechins, and used a dietary supplement intervention. A significantly negative effect on leptin levels was observed in studies conducted in Asian countries, with healthy participants and participants with T2DM, used whole food interventions, and involved participants with lower baseline leptin levels. In conclusion, flavonoid intake significantly increased circulating adiponectin and decreased leptin levels; however, study heterogeneity was very high.Future well-designed trials are required to address heterogeneous study designs and clarify the efficacy of plants in regulating adiponectin and leptin levels.

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“…Mohsenzadeh et al have shown that vascular toxicity induced by BPA was prevented by the co-supplementation of green tea extract, epigallocatechin gallate (EGCG), or vitamin E in rats [ 230 ]. Another experimental study in rats has shown that green tea extract or EGCG co-supplementation prevented metabolic disorders induced by BPA through improving insulin signaling pathways ( Figure 2 ) and lipid metabolism, which are attributed to their anti-inflammatory, and antioxidant properties [ 231 ]. An in vitro and in silico study by Suthar et al revealed that green tea extract significantly mitigated the oxidative stress induced by BPA on erythrocytes [ 232 ].…”

Section: Various Natural Products That Are Effective Against Bpa-indu...mentioning

confidence: 99%

“… ( a ) The schematic representation of the insulin signaling promoting potential of resveratrol, grape seed extract [ 183 ], and epigallocatechin gallate (EGCG) [ 231 ]. ( b ) Developmental BPA exposure is associated with anxiogenic effects in juvenile rats via downregulating the expression of estrogen receptor beta (Esr2) and melanocortin receptors (Mc3r, Mc4r) in amygdala.…”

Section: Various Natural Products That Are Effective Against Bpa-indu...mentioning

confidence: 99%

Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use

et al. 2022

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Bisphenol A (BPA) is a ubiquitous environmental toxin with deleterious endocrine-disrupting effects. It is widely used in producing epoxy resins, polycarbonate plastics, and polyvinyl chloride plastics. Human beings are regularly exposed to BPA through inhalation, ingestion, and topical absorption routes. The prevalence of BPA exposure has considerably increased over the past decades. Previous research studies have found a plethora of evidence of BPA’s harmful effects. Interestingly, even at a lower concentration, this industrial product was found to be harmful at cellular and tissue levels, affecting various body functions. A noble and possible treatment could be made plausible by using natural products (NPs). In this review, we highlight existing experimental evidence of NPs against BPA exposure-induced adverse effects, which involve the body’s reproductive, neurological, hepatic, renal, cardiovascular, and endocrine systems. The review also focuses on the targeted signaling pathways of NPs involved in BPA-induced toxicity. Although potential molecular mechanisms underlying BPA-induced toxicity have been investigated, there is currently no specific targeted treatment for BPA-induced toxicity. Hence, natural products could be considered for future therapeutic use against adverse and harmful effects of BPA exposure.

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Potential role of green tea extract and epigallocatechin gallate in preventing bisphenol A-induced metabolic disorders in rats: Biochemical and molecular evidence

Cited by 11 publications

References 111 publications

Hepatoprotective effect of Artemisia Argyi essential oil on bisphenol A‐induced hepatotoxicity via inhibition of ferroptosis in mice

Hepatoprotective effect of Artemisia Argyi essential oil on bisphenol A‐induced hepatotoxicity via inhibition of ferroptosis in mice

Effect of flavonoid intake on circulating levels of adiponectin and leptin: A systematic review and meta‐analysis of randomized controlled clinical trials

Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use

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