Potential Role of Gut Microbiota in Traditional Chinese Medicine against COVID-19

Zhang, Grace; Yue, Shi‐Jun; Wang, Wenxiao; Chen, Yanyan; Zhao, Chongbo; Song, Yijun; Yan, Dan; Zhang, Li; Tang, Yuping

doi:10.1142/s0192415x21500373

Cited by 23 publications

(18 citation statements)

References 97 publications

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“…Therefore, it was also recommended for the recovery of gut microbiota balance while treating COVID-19 patients . Many Chinese herbs and preparations have demonstrated properties of restoring intestinal barrier function and intestinal homeostasis, which may further modulate the immune function after SARS-CoV-2 infection. , Understanding the role of compounds in maintaining intestinal flora balance could provide new ideas for preventing and treating COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Dissection of the Active Ingredients and Potential Mechanism of Han-Shi-Yu-Fei-Decoction in Treating COVID-19 Based on In Vivo Substances Profiling and Clinical Symptom-Guided Network Pharmacology

et al. 2022

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This work was aimed to elucidate the mechanism of action of Han-Shi-Yu-Fei-decoction (HSYFD) for treating patients with mild coronavirus disease 2019 (COVID-19) based on clinical symptom-guided network pharmacology. Experimentally, an ultra-high performance liquid chromatography technique coupled with quadrupole time-of-flight mass spectrometry method was used to profile the chemical components and the absorbed prototype constituents in rat serum after its oral administration, and 11 out of 108 compounds were identified. Calculatingly, the disease targets of Han-Shi-Yu-Fei symptoms of COVID-19 were constructed through the TCMIP V2.0 database. The subsequent network pharmacology and molecular docking analysis explored the molecular mechanism of the absorbed prototype constituents in the treatment of COVID-19. A total of 42 HSYFD targets oriented by COVID-19 clinical symptom were obtained, with EGFR, TP53, TNF, JAK2, NR3C1, TH, COMT, and DRD2 as the core targets. Enriched pathway analysis yielded multiple COVID-19-related signaling pathways, such as the PI3K/AKT signaling pathway and JAK-STAT pathway. Molecular docking showed that the key compounds, such as 6-gingerol, 10-gingerol, and scopoletin, had high binding activity to the core targets like COMT, JAK2, and NR3C1. Our work also verified the feasibility of clinical symptom-guided network pharmacology analysis of chemical compounds, and provided a possible agreement between the points of views of traditional Chinese medicine and western medicine on the disease.

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Section: Discussionmentioning

confidence: 99%

Dissection of the Active Ingredients and Potential Mechanism of Han-Shi-Yu-Fei-Decoction in Treating COVID-19 Based on In Vivo Substances Profiling and Clinical Symptom-Guided Network Pharmacology

et al. 2022

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“…It is worth noting that the potential role of GM in traditional Chinese herbal medicines for the attenuation of SARS-CoV-2 has been demonstrated earlier (see [ 133 ]). On the other hand, Chen et al have reviewed and listed the roles of medicinal plants to include ACE2 inhibition in the GI tract, support in restoration of the GI flora for the regulation of intestinal mucosal barrier and respiratory immunity, and the attenuators of the specific complexities that caused by COVID-19 disease [ 35 ].…”

Section: Main Textmentioning

confidence: 97%

“…Targeting gut microbiota (GM) to prevent and treat COVID-19 has been viewed as an alternative strategy [ 101 ] as GM plays an important role in the maintenance of host homeostasis, and GM can modulate ACE2 which is expressed in intestinal cells and is crucial for the entry of SARS-CoV-2 into the host cells [ 133 ]. Dysbiosis of GM or altered oral microbiome has a correlation with the severity and hospitalization of COVID-19 in patients compared to healthy individuals [ 125 , 130 ] as well to produce pro-inflammatory cytokines [ 5 ].…”

Section: Main Textmentioning

confidence: 99%

Role of ethno-phytomedicine knowledge in healthcare of COVID-19: advances in traditional phytomedicine perspective

Ahmed

Hughes²

2022

Beni-Suef Univ J Basic Appl Sci

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Background Since the outbreak of the COVID-19 virus, ethnomedicinal plants have been used in diverse geographical locations for their purported prophylactic and pharmacological effects. Medicinal plants have been relied on by people around the globe for centuries, as 80% of the world’s population rely on herbal medicines for some aspect of their primary health care needs, according to the World Health Organization. Main body This review portrays advances in traditional phytomedicine by bridging the knowledge of ethno-phytomedicine and COVID-19 healthcare. Ethnomedicinal plants have been used for symptoms related to COVID-19 as antiviral, anti-infective, anti-inflammatory, anti-oxidant, antipyretic, and lung–gut immune boosters. Traditionally used medicinal plants have the ability to inhibit virus entry and viral assembly, bind to spike proteins, membrane proteins, and block viral replications and enzymes. The efficacy of traditional medicinal plants in the terms of COVID-19 management can be evaluated by in vitro, in vivo as well as different in silico techniques (molecular docking, molecular dynamics simulations, machine learning, etc.) which have been applied extensively to the quest and design of effective biotherapeutics rapidly. Other advances in traditional phytomedicines against COVID-19 are controlled clinical trials, and notably the roles in the gut microbiome. Targeting the gut microbiome via medicinal plants as prebiotics is also found to be an alternative and potential strategy in the search for a COVID-19 combat strategy. Conclusions Since medicinal plants are the sources of modern biotherapeutics development, it is essential to build collaborations among ethnobotanists, scientists, and technologists toward developing the most efficient and the safest adjuvant therapeutics against the pandemic of the twenty-first century, COVID-19.

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“…Indeed, numerous studies have demonstrated that ethnic medicines can reverse intestinal microecological disorders caused by pathogen infections ( Wu and Tan, 2019 ; Lin et al., 2021 ). For instance, ethnomedicines such as berberine, baicalin, apigenin ( Radulovic et al., 2018 ), and sulforaphene ( Li et al., 2017 ) have been shown to restore normal gut flora balance after pathogen infection-induced disruption by increasing the abundance of probiotic organisms in the gut ( Li et al., 2011 ; Wu et al., 2018 ; Zhang et al., 2021 ). One possible mechanism associated with beneficial effects of one of these medicines, baicalin, for protecting rats against gut microbiota imbalance was linked to modulation of SCFAs content ( Zhu et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota and SCFAs Play Key Roles in QingFei Yin Recipe Anti-Streptococcal Pneumonia Effects

Sun

Wang

Wei

et al. 2021

Front. Cell. Infect. Microbiol.

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Emerging evidence has revealed the presence in animals of a bidirectional regulatory “lung-gut axis” that provides resistance to respiratory infections. Clues to the existence of this system stem from observations that respiratory infections are often accompanied by gastrointestinal symptoms, whereby intestinal microbiota appear to play pivotal roles in combating pathogenic infections. Importantly, short-chain fatty acids (SCFAs) produced by the gut microbiota appear to serve as the biological link between host immune defenses and gut flora. Streptococcus pneumoniae (S.pn), the main cause of lower respiratory tract infections, is involved in more than 1.189 million deaths per year. QingFei Yin (QFY) is known for its excellent therapeutic efficacy in combating bacterial lung infections. In this study, effects of S.pn infection on gut homeostasis were assessed using 16S RNA-based microbiota community profiling analysis. In addition, potential mechanisms underlying QFY recipe beneficial therapeutic effects against bacterial pneumonia were explored using S.pn-infected gut microbiota-depleted mice. Results of data analysis indicated that QFY treatment alleviated lung infection-associated pathogenic processes, while also promoting repair of disordered gut flora and counteracting S.pn infection-associated decreases in levels of SCFAs, particularly of acetate and butyrate. Mechanistically, QFY treatment suppressed inflammatory lung injury through inhibition of the host NF-κB-NLRP3 pathway. These results inspired us to identify precise QFY targets and mechanisms underlying QFY anti-inflammatory effects. In addition, we conducted an in-depth evaluation of QFY as a potential treatment for bacterial pneumonia.

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Potential Role of Gut Microbiota in Traditional Chinese Medicine against COVID-19

Cited by 23 publications

References 97 publications

Dissection of the Active Ingredients and Potential Mechanism of Han-Shi-Yu-Fei-Decoction in Treating COVID-19 Based on In Vivo Substances Profiling and Clinical Symptom-Guided Network Pharmacology

Dissection of the Active Ingredients and Potential Mechanism of Han-Shi-Yu-Fei-Decoction in Treating COVID-19 Based on In Vivo Substances Profiling and Clinical Symptom-Guided Network Pharmacology

Role of ethno-phytomedicine knowledge in healthcare of COVID-19: advances in traditional phytomedicine perspective

Gut Microbiota and SCFAs Play Key Roles in QingFei Yin Recipe Anti-Streptococcal Pneumonia Effects

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