Potential Role of Life Stress in Unexplained Sudden Cardiac Arrest

Abstract

Background The etiology of sudden cardiac arrest (SCA) in individuals without known cardiovascular heart disease remains elusive in nearly half of all patients after systematic testing. We investigated the relationship between stressful life events and SCA risk in cases of explained and unexplained SCA (USCA) events. Methods Individuals who previously experienced SCA were enrolled prospectively and divided into a USCA or explained SCA (ESCA) subgroup dependent on whether a diagnosis was ascribed after SCA. Participants completed either the 1997 Recent Life Changes Questionnaire, Student Stress Scale, or Social Re-adjustment Rating Scale for Non-Adults recalling events during the year preceding their SCA, depending on age at SCA presentation; all measure stress in life change units (LCUs). SCA group scores were compared with an age- and sex-matched control group. Results We compared 36 SCA group participants (22 USCA, 14 ESCA, age 47 ± 15 years, age at SCA 40 ± 14 years, 50% male) with 36 control participants (age 47 ± 15 years, 50% male). There was no significant difference in LCU score between the control group and the SCA group (248 ± 181 LCU vs 252 ± 227 LCU; P > .05). The ESCA subgroup had significantly lower mean LCU scores than the USCA subgroup (163 ± 183 LCU vs 308 ± 237 LCU; P = .030). Conclusions Stressful life events, especially those producing chronic stress, might predispose otherwise healthy individuals to lethal arrhythmias. Further investigation into the role of stress in SCA precipitation is warranted.

Technologization of sudden cardiac death prevention based on the disciplinary-methodological matrix of health-preserving competence

“…3) Infectious factors: herpetic infection, flu including COVID-19 [11], other infections. 4) Non-infectious diseases, in particular, diabetes [18,28]. 5) Substances that have a neurotropic [22] and psychotropic effect: medicines, alcohol, drugs, smoking, as well as anabolic steroids.…”

“…Chang Liu et al [18] are investigating sudden cardiac death in persons who do not have cardiac disorders. They points to the significant role of stress as an etiological factor of this pathology.…”

Phosphate toxicity and SERCA2a dysfunction in sudden cardiac arrest

“…2 Yet, nearly half of individuals with sudden cardiac arrest have no detected "coronary or structural heart disease". 3 Among children and young adults, the cause of approximately one-third of sudden cardiac deaths remains unexplained after thorough examination. 4,5 Consequently, "unexplained sudden cardiac death is often attributed to cardiac arrhythmia caused by cardiac ion-channel dysfunction, which is undetectable in a conventional autopsy".…”

“…In sudden cardiac death, closely related to sudden cardiac arrest, “nine out of 10 people who have a cardiac arrest outside of a hospital die—often within minutes” 2 . Yet, nearly half of individuals with sudden cardiac arrest have no detected “coronary or structural heart disease” 3 . Among children and young adults, the cause of approximately one‐third of sudden cardiac deaths remains unexplained after thorough examination 4,5 .…”