Potential role of sirtuins in livestock production

Ghinis-Hozumi, Y.; Antaramián, Anaid; Villarroya, Francesc; Piña, Enrique; Mora, Ofelia

doi:10.1017/s1751731112001115

Cited by 11 publications

(8 citation statements)

References 115 publications

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“…Sirt1 expression of fatty pigs was greater than lean pigs in brain. Except Sirt1, the most extensively studied Sirtuins, the expression and function of other Sirtuins in pigs are little known (Ghinis-Hozumi et al, 2013). We also studied the expression pattern of Sirt2-7 in brain and found that the mRNA levels of Sirt2 and Sirt4 of fatty Jinhua pigs were greater, while the mRNA levels of Sirt3-7 of lean Landrace pigs were greater at the age of 180 days.…”

Section: Discussionmentioning

confidence: 90%

“…Since Sirt2 and Sirt4 also highly expressed in brain of Jinhua pigs, Sirt1, Sirt2, and Sirt4 may play critical roles in brain antioxidant capacity in pigs. Sirtuins have been proved to play an important role in the regulation of energy balance in livestock (Ghinis-Hozumi et al, 2013), however there is little research about the role of Sirtuins and antioxidant capacity in porcine brain. Our results will add new knowledge to Sirtuins' function in livestock.…”

Section: Discussionmentioning

confidence: 99%

“…In pigs, high levels of porcine Sirt1-7 mRNA were also found in brain (Shan et al, 2009;Ghinis-Hozumi et al, 2013). At the same time, the antioxidants such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activity in pork could be affected by genetic type (Hernandez et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Effect of breed on the expression of Sirtuins (Sirt1-7) and antioxidant capacity in porcine brain

Ren

Shan

Zhu

et al. 2013

Animal

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Sirtuins, NAD-dependent histone deacetylase (HDAC), are correlated to aging and antioxidant. The aim of this study was to determine breed differences of porcine Sirtuins expression and antioxidant capacity in brain between Jinhua pigs (a fatty breed of China) and Danish Landrace pigs (a leaner breed). Effect of age on Sirtuins' expression was also investigated. At the age of 180 days, the mRNA levels of Sirt1, as well as Sirt2 and Sirt4, in Jinhua pigs were greater, but the mRNA levels of Sirt3, Sirt5, Sirt6, and Sirt7 of Jinhua pigs were lower compared with Danish Landrace pigs. Likewise, at the same BW of 64 kg, the mRNA levels of Sirtuins, except Sirt5 and Sirt7, in Jinhua pigs were greater than Danish Landrace pigs. Meanwhile, Jinhua pigs possessed higher antioxidants activity than Danish Landrace pigs either at the same age or at the same BW. Furthermore, mRNA levels of Sirtuins were decreased with age in brain of the two breeds from 30 to 120 days. The results indicated that Sirtuins expression in brain was different between fatty and lean pigs, and Sirtuins expression may be correlated to antioxidant capacity. In addition, age could down-regulate Siruins expression in porcine brain.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Effect of breed on the expression of Sirtuins (Sirt1-7) and antioxidant capacity in porcine brain

Ren

Shan

Zhu

et al. 2013

Animal

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“…Other studies in fish have related SIRTs to ammonia levels (Connon et al, 2011 ), cold exposure (Teigen et al, 2015 ), spatial learning (Rajan et al, 2015 ), changes in blood glucose (Otero-Rodiño et al, 2016 ) and adipocyte maturation during hypoxia (Ekambaram and Parasuraman, 2017 ). Nevertheless, SIRT function and regulation remain poorly studied in fish and in livestock animals in general (Ghinis-Hozumi et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Co-expression Analysis of Sirtuins and Related Metabolic Biomarkers in Juveniles of Gilthead Sea Bream (Sparus aurata) With Differences in Growth Performance

et al. 2018

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Sirtuins (SIRTs) represent a conserved protein family of deacetylases that act as master regulators of metabolism, but little is known about their roles in fish and livestock animals in general. The present study aimed to assess the value of SIRTs for the metabolic phenotyping of fish by assessing their co-expression with a wide-representation of markers of energy and lipid metabolism and intestinal function and health in two genetically different gilthead sea bream strains with differences in growth performance. Fish from the fast-growing strain exhibited higher feed intake, feed efficiency and plasma IGF-I levels, along with higher hepatosomatic index and lower mesenteric fat (lean phenotype). These observations suggest differences in tissue energy partitioning with an increased flux of fatty acids from adipose tissue toward the liver. The resulting increased risk of hepatic steatosis may be counteracted in the liver by reduced lipogenesis and enhanced triglyceride catabolism, in combination with a higher and more efficient oxidative metabolism in white skeletal muscle. These effects were supported by co-regulated changes in the expression profile of SIRTs (liver, sirt1; skeletal muscle, sirt2; adipose tissue, sirt5-6) and markers of oxidative metabolism (pgc1α, cpt1a, cs, nd2, cox1), mitochondrial respiration uncoupling (ucp3) and fatty acid and triglyceride metabolism (pparα, pparγ, elovl5, scd1a, lpl, atgl) that were specific to each strain and tissue. The anterior intestine of the fast-growing strain was better suited to cope with improved growth by increased expression of markers of nutrient absorption (fabp2), epithelial barrier integrity (cdh1, cdh17) and immunity (il1β, cd8b, lgals1, lgals8, sIgT, mIgT), which were correlated with low expression levels of sirt4 and markers of fatty acid oxidation (cpt1a). In the posterior intestine, the fast-growing strain showed a consistent up-regulation of sirt2, sirt3, sirt5 and sirt7 concurrently with increased expression levels of markers of cell proliferation (pcna), oxidative metabolism (nd2) and immunity (sIgT, mIgT). Together, these findings indicate that SIRTs may play different roles in the regulation of metabolism, inflammatory tone and growth in farmed fish, arising as powerful biomarkers for a reliable metabolic phenotyping of fish at the tissue-specific level.

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“…Few SIRT2 variants have been reported to date for cattle, as most research has focused on rodents and human models [ 11 ]. The Qinchuan breed of cattle ( Bos taurus ) used in our research is one of the outstanding indigenous breeds in China, known for its excellent adaptability and physical features.…”

Section: Introductionmentioning

confidence: 99%

Expression of the SIRT2 Gene and Its Relationship with Body Size Traits in Qinchuan Cattle (Bos taurus)

Gui

Zhang

Liu

et al. 2015

IJMS

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Silent information regulator 2 (SIRT2) is a member of the sirtuin family of class III NAD (nicotinamide adenine dinucleotide)-dependent protein deacetylases and may regulate senescence, metabolism and apoptosis. The aims of this study were to investigate whether the SIRT2 gene could be used as a candidate gene in the breeding of Qinchuan cattle. Real-time polymerase chain reaction (RT-PCR) results showed that among all types of tissue that were analyzed, the highest mRNA expression levels of the gene were found in subcutaneous fat. DNA sequencing of 468 individual Qinchuan cattle identified two novel, single nucleotide polymorphisms (g.19501 C > T and g.19518 C > T) in the 3' untranslated region (3'UTR) of the SIRT2 gene. The frequencies of SNP g.19501 C > T and g.19518 C > T were in Hardy-Weinberg disequilibrium in all the samples (chi-square test, χ2 < χ0.052). An association analysis showed that the two loci were significantly correlated with some body size traits and the H2H2 (-CT-CT-) diplotypes performed better than other combinations. These results indicated that the variations in the SIRT2 gene and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

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Potential role of sirtuins in livestock production

Cited by 11 publications

References 115 publications

Effect of breed on the expression of Sirtuins (Sirt1-7) and antioxidant capacity in porcine brain

Effect of breed on the expression of Sirtuins (Sirt1-7) and antioxidant capacity in porcine brain

Co-expression Analysis of Sirtuins and Related Metabolic Biomarkers in Juveniles of Gilthead Sea Bream (Sparus aurata) With Differences in Growth Performance

Expression of the SIRT2 Gene and Its Relationship with Body Size Traits in Qinchuan Cattle (Bos taurus)

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