Potential Role of the Amygdala and Posterior Claustrum in Exercise Intensity-dependent Cardiovascular Regulation in Rats

Kim, Jimmy; Yamanaka, Koji; Tsukioka, Kei; Waki, Hidefumi

doi:10.1016/j.neuroscience.2020.02.024

Cited by 8 publications

(12 citation statements)

References 57 publications

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“…On the other hand, the neuronal circuits of aversion-predictive depressive responses are still unclear. Based on behavioral and autonomic aspects and functional connections to the amygdala, possible candidates are the midbrain periaqueductal gray which is involved in negative emotional processing and freezing behavior induced by fearful stimuli (Amorapanth et al 1999;Buhle et al 2013), and the claustrum which shows depressive responses to arti cial stimulation and functionally connected with the amygdala (Kim et al 2020). Thus, future studies should further examine the functions of neuronal circuits that may support and maintain the emotional expression suitable for a dynamically changing environment.…”

Section: Discussionmentioning

confidence: 99%

“…We previously showed that electrical and chemical stimulations of the central nucleus of the amygdala (CeA) in anesthetized rats induced bidirectional (facilitatory or inhibitory) cardiovascular responses in a region-speci c manner (Yamanaka et al 2018). In behavioral animals, we observed a sudden increase in the blood pressure immediately before exhaustion during high-intensity treadmill running with negative emotion and strong c-Fos expression in the amygdala (Kim et al 2020).…”

Section: Introductionmentioning

confidence: 94%

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Regulation of blood pressure by the central nucleus of the amygdala in dynamically changing appetitive and aversive classical conditioning tasks in rats

Yamanaka

Waki

2021

Preprint

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In an environment of dynamically changing conditions, humans and animals can determine whether a current situation is favorable to them and accordingly select actions. Autonomic cardiovascular tuning is as important as motor control for this function. However, neuronal mechanisms underlying the dynamic adjustments of autonomic cardiovascular responses remain unclear. In this study, we hypothesized that the amygdala plays a role in autonomic cardiovascular tuning in a dynamically changing situation. We recorded the blood pressures and heart rates of head-restrained rats during appetitive and aversive classical conditioning tasks. Rats learned varying associations between conditioned stimuli and unconditioned stimuli in appetitive, neutral, and aversive blocks. Blood pressure and heart rate in the appetitive block gradually increased in response to reward-predicting cue, preceded by a vigorously increased response to the actual reward. The predictive response was significantly higher than the responses in the neutral and aversive condition blocks. Blood pressure and heart rate responses to the air puff-predicting cue in the aversive block were significantly lower than that of the responses in the neutral block. The conditioned blood pressure response rapidly changed through condition switching. Furthermore, bilateral pharmacological inactivation of the central nucleus of the amygdala has significantly decreased reward-predictive pressor responses in the latter phase, but not in the initial phase of block change. These results suggest that blood pressure is adaptively tuned by positive and negative conditioned stimuli and that the central nucleus of the amygdala likely assists in maintaining pressor response in dynamically changing situations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Regulation of blood pressure by the central nucleus of the amygdala in dynamically changing appetitive and aversive classical conditioning tasks in rats

Yamanaka

Waki

2021

Preprint

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“…To monitor cardiovascular parameters, including HR, from continuously measured arterial pressure, the rats were catheterized in the abdominal aorta and implanted with a radio transmitter (HD-S10; Data Sciences International, St. Paul, MN, USA) under anesthesia, as described previously (Waki et al, 2003;Yamanaka et al, 2018;Tsukioka et al, 2019;Kim et al, 2020). The catheter was secured in the aorta with tissue adhesive Vetbond (3M, MN, USA) and a cellulose patch.…”

Section: Surgical Implantation Of Radio Transmittermentioning

confidence: 99%

“…Recently, we revealed that c-Fos expression, a marker of neuronal activity, was exaggerated in the CeA in response to prolonged and high-intensity exercise but not to low-intensity exercise (Kim et al, 2020). Thus, CeA activation may be related to negative emotions during high-intensity exercise.…”

Section: Introductionmentioning

confidence: 95%

Implication of the Central Nucleus of the Amygdala in Cardiovascular Regulation and Limiting Maximum Exercise Performance During High-intensity Exercise in Rats

Tsukioka

Yamanaka²,

Waki³

2022

Neuroscience

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“…We showed that electrical and chemical stimulation of the central nucleus of the amygdala (CeA) in anesthetized rats induced bidirectional (facilitatory or inhibitory) cardiovascular responses in a region-speci c manner, indicating that the amygdala displays the neuronal circuitry for modulating autonomic responses 12 . In fact, high-intensity treadmill running with negative emotion has caused a sudden increase in blood pressure immediately before exhaustion and strong c-Fos expression in the amygdala 13 . Conditioned cardiovascular responses are classically recorded during anticipation of either appetitive or aversive outcomes 14,15 .…”

Section: Introductionmentioning

confidence: 99%

Maintenance of Blood Pressure in Emotional Context-based Autonomic Switching by the Central Nucleus of the Amygdala in Rats

Yamanaka¹,

Waki²

2020

Preprint

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Proper autonomic control is necessary in making appropriate decisions and actions, but neuronal mechanisms for this function are yet to be determined. Here we show that the amygdala plays a role in autonomic cardiovascular tuning in a dynamically changing environment. We recorded blood pressure and heart rate of head-restrained rats during appetitive and aversive classical conditioning tasks. Rats learned varying associations between conditioned stimuli and unconditioned stimuli in three types of contexts: appetitive, neutral, and aversive blocks. Blood pressure and heart rate in the appetitive block gradually increased after reward-predicting cues, followed by a vigorously increased response to the actual reward. The predictive response was found to be significantly higher than the responses in the neutral and aversive blocks. Blood pressure and heart rate responses to the air puff-predicting cue in the aversive block were significantly lower than that of the responses in the neutral block. Pharmacological blockade of the amygdala has significantly decreased reward-predictive pressor responses in the latter phase, but not in the initial phase of context change. Cardiovascular responses are thus adaptively tuned by positive and negative emotional stimuli, and the central nucleus of the amygdala likely assists in maintaining pressor response tuning based on emotional context.

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Potential Role of the Amygdala and Posterior Claustrum in Exercise Intensity-dependent Cardiovascular Regulation in Rats

Cited by 8 publications

References 57 publications

Regulation of blood pressure by the central nucleus of the amygdala in dynamically changing appetitive and aversive classical conditioning tasks in rats

Regulation of blood pressure by the central nucleus of the amygdala in dynamically changing appetitive and aversive classical conditioning tasks in rats

Implication of the Central Nucleus of the Amygdala in Cardiovascular Regulation and Limiting Maximum Exercise Performance During High-intensity Exercise in Rats

Maintenance of Blood Pressure in Emotional Context-based Autonomic Switching by the Central Nucleus of the Amygdala in Rats

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