Potential Signal Transduction Regulation by HDL of the β2-Adrenergic Receptor Pathway. Implications in Selected Pathological Situations

Niesor, Eric J.; Benghozi, Renée

doi:10.1016/j.arcmed.2015.05.008

Cited by 8 publications

(8 citation statements)

References 86 publications

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“…The ADCY9 protein is a membrane-bound enzyme that catalyzes the formation of cyclic Adenosine monophosphate (cAMP) from Adenosine triphosphate (ATP) (Hacker et al, 1998) in the estrogen signaling pathway. ADCY9 protein is affected by changes in membrane-rich cholesterol plasma membrane domains (Niesor and Benghozi, 2015). Reduced amplitude of cAMP circadian oscillation was probably associated with changed expression of ADCY9 (Baburski et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Based Estrogen Related Genes Biomarkers for Diagnosis and Prognosis in Non-small Cell Lung Cancer

Jia

Xie

et al. 2021

Front. Genet.

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BackgroundLung cancer is the tumor with the highest morbidity and mortality, and has become a global public health problem. The incidence of lung cancer in men has declined in some countries and regions, while the incidence of lung cancer in women has been slowly increasing. Therefore, the aim is to explore whether estrogen-related genes are associated with the incidence and prognosis of lung cancer.MethodsWe obtained all estrogen receptor genes and estrogen signaling pathway genes in The Cancer Genome Atlas (TCGA), and then compared the expression of each gene in tumor tissues and adjacent normal tissues for lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) separately. Survival analysis was performed of the differentially expressed genes in LUAD and LUSC patients separately. The diagnostic and prognostic values of the candidate genes were validated in the Gene Expression Omnibus (GEO) datasets.ResultsWe found 5 estrogen receptor genes and 66 estrogen pathway genes in TCGA. A total of 50 genes were differently expressed between tumor tissues and adjacent normal tissues and 6 of the 50 genes were related to the prognosis of LUAD in TCGA. 56 genes were differently expressed between tumor tissues and adjacent normal tissues and none of the 56 genes was related to the prognosis of LUSC in TCGA. GEO datasets validated that the 6 genes (SHC1, FKBP4, NRAS, PRKCD, KRAS, ADCY9) had different expression between tumor tissues and adjacent normal tissues in LUAD, and 3 genes (FKBP4, KRAS, ADCY9) were related to the prognosis of LUAD.ConclusionsThe expressions of FKBP4 and ADCY9 are related to the pathogenesis and prognosis of LUAD. FKBP4 and ADCY9 may serve as biomarkers in LUAD screening and prognosis prediction in clinical settings.

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Section: Discussionmentioning

confidence: 99%

Transcriptome Based Estrogen Related Genes Biomarkers for Diagnosis and Prognosis in Non-small Cell Lung Cancer

Jia

Xie

et al. 2021

Front. Genet.

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“…Research shows that adenylyl cyclase 9 is linked to HDL function and may result in cardiovascular events in multiple pathologies (39,40). Downregulation of ADCY9 is related to positive effects on atherosclerosis and cardiovascular endothelial function and a gain in adipose tissue volume in the absence of CETP (18,41).…”

Section: Discussionmentioning

confidence: 99%

“…Among all the subtypes of adenylate cyclase, ADCY9 is the only membrane-bound AC subtype that is not sensitive to the adenylate cyclase activator. It is capable of being stimulated by beta-adrenergic receptor activation and is insensitive to forskolin, calcium, and somatostatin, which contributes to the CRH, corticosteroids and beta-adrenergic signaling pathway cascades ( 34 , 38 , 39 ). Research shows that adenylyl cyclase 9 is linked to HDL function and may result in cardiovascular events in multiple pathologies ( 39 , 40 ).…”

Section: Discussionmentioning

confidence: 99%

ADCY9 functions as a novel cancer suppressor gene in lung adenocarcinoma

Tang¹,

Wang²,

Zhang³

et al. 2023

J Thorac Dis

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Background: The process of lucubrating into lung adenocarcinoma (LUAD) is of profound clinical and practical significance in improving the prognosis of LUAD patients. Multiple biomarkers are reportedly involved in the proliferation or metastasis of adenocarcinoma. However, whether the ADCY9 gene influences the development of LUAD remains unknown. Therefore, we aimed to elucidate the relationship between the expression of ADCY9 and the proliferation and migration of LUAD.Methods: The ADCY9 gene was filtered via a survival analysis of LUAD acquired from the Gene Expression Omnibus (GEO). Then, we conducted a validation analysis and ADCY9-microRNA, microRNA-lncRNA, and ADCY9-lncRNA targeting relationship analysis through the data obtained from The Cancer Genome Atlas (TCGA) dataset. The survival curve, correlation, and prognostic analysis were implemented through bioinformatics methods. Both protein and mRNA expression levels of LUAD cell lines and LUAD patient samples (80 pairs) were detected using western blot assays and quantitative real-time polymerase chain reaction (qRT-PCR). An immunohistochemistry assay was performed to display the correlation between the expression level of the ADCY9 gene and prognosis in LUAD patients (2012-2013; n=115).Overexpression of cell lines SPCA1 and A549 were used for a series of cell function assays. Results:Compared with the expression level in adjacent normal tissues, ADCY9 expression was downregulated in LUAD tissues. Based on the result of the survival curve analysis, high expression of ADCY9 may lead to a better prognosis and may be seen as an independent predictor for LUAD patients. High expression of ADCY9-related microRNA hsa-miR-7-5p may lead to a worse prognosis, and high expression of hsa-miR-7-5p-related lncRNAs may lead to the opposite effects. Overexpression of ADCY9 restrained the proliferation, invasion, and migration abilities of SPCA1, A549 cells. Conclusions:Results indicate that the ADCY9 gene acts as a tumor suppressor to restrain the proliferation, migration, and invasion in LUAD and can lead to a better survival or prognosis in LUAD patients.

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“…Abnormal cholesterol metabolism is closely related to HDL and LDL levels. The main atheroprotective mechanism of HDL is reverse cholesterol transport, whereby excess cholesterol is transported from peripheral tissues to the liver for elimination [ 33 ]. In contrast, cholesterol is removed from the liver to surrounding tissues by LDL, and LDL levels are related to the risk of atherosclerosis [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease

Niu

Jia

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease. Currently, there are no recognized medical therapies effective for NAFLD. Previous studies have demonstrated the effects of total turmeric extract on rats with NAFLD induced by high-fat diet. In this study, serum metabolomics was employed using UHPLC-Q-TOF-MS to elucidate the underlying mechanisms of HFD-induced NAFLD and the therapeutic effects of TE. Supervised orthogonal partial least-squares-discriminant analysis was used to discover differentiating metabolites, and pathway enrichment analysis suggested that TE had powerful combined effects of regulating lipid metabolism by affecting glycerophospholipid metabolism, glycerolipid metabolism, and steroid hormone biosynthesis signaling pathways. In addition, the significant changes in glycerophospholipid metabolism proteins also indicated that glycerophospholipid metabolism might be involved in the therapeutic effect of TE on NAFLD. Our findings not only supply systematic insight into the mechanisms of NAFLD but also provide a theoretical basis for the prevention or treatment of NAFLD.

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Potential Signal Transduction Regulation by HDL of the β2-Adrenergic Receptor Pathway. Implications in Selected Pathological Situations

Cited by 8 publications

References 86 publications

Transcriptome Based Estrogen Related Genes Biomarkers for Diagnosis and Prognosis in Non-small Cell Lung Cancer

Transcriptome Based Estrogen Related Genes Biomarkers for Diagnosis and Prognosis in Non-small Cell Lung Cancer

ADCY9 functions as a novel cancer suppressor gene in lung adenocarcinoma

Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease

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