Potential silver nanoparticles migration from commercially available polymeric baby products into food simulants

Choi, Jeong In; Chae, Song Ji; Kim, Jung Min; Choi, Ji‐Yeob; Park, Se Jong; Choi, Hee Ju; Bae, Hojae; Park, Hyun Jin

doi:10.1080/19440049.2017.1411611

Cited by 21 publications

(11 citation statements)

References 29 publications

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“…Thus, the presence of AgNPs in dietary supplements, water contamination, or food fish and other aquatic organisms provides the potential sources of oral exposure [23]. Recent studies have also demonstrated that AgNPs incorporated in food packaging can migrate from packaging into food under several usage conditions [95,96]. Inhalation exposure during manufacturing also ultimately leads to oral exposure, since particles cleared via the mucociliary escalator are swallowed and cleared through the GIT.…”

Section: Oral Exposurementioning

confidence: 99%

Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure

Ferdous

Nemmar

2020

IJMS

701

354

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Engineered nanomaterials (ENMs) have gained huge importance in technological advancements over the past few years. Among the various ENMs, silver nanoparticles (AgNPs) have become one of the most explored nanotechnology-derived nanostructures and have been intensively investigated for their unique physicochemical properties. The widespread commercial and biomedical application of nanosilver include its use as a catalyst and an optical receptor in cosmetics, electronics and textile engineering, as a bactericidal agent, and in wound dressings, surgical instruments, and disinfectants. This, in turn, has increased the potential for interactions of AgNPs with terrestrial and aquatic environments, as well as potential exposure and toxicity to human health. In the present review, after giving an overview of ENMs, we discuss the current advances on the physiochemical properties of AgNPs with specific emphasis on biodistribution and both in vitro and in vivo toxicity following various routes of exposure. Most in vitro studies have demonstrated the size-, dose- and coating-dependent cellular uptake of AgNPs. Following NPs exposure, in vivo biodistribution studies have reported Ag accumulation and toxicity to local as well as distant organs. Though there has been an increase in the number of studies in this area, more investigations are required to understand the mechanisms of toxicity following various modes of exposure to AgNPs.

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Section: Oral Exposurementioning

confidence: 99%

Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure

Ferdous

Nemmar

2020

IJMS

701

354

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“…If PNCs find use as food contact materials, they could potentially be a source of human dietary exposure to engineered nanomaterials (ENMs). Consequently, studies have explored whether nanofillers can transfer out of PNCs into foods and other environments under intended use conditions. , This body of work has mostly focused on silver nanoparticles (AgNPs), − but nanoclay, , metal oxide, , carbonaceous, − or other − nanofillers have also been investigated. These studies have established that nanofiller mass (e.g., Ag) is usually released from PNCs during long-term storage, and factors like food pH, embedded particle characteristics (size, composition), and polymer properties impact this process.…”

Section: Introductionmentioning

confidence: 99%

Food and Beverage Ingredients Induce the Formation of Silver Nanoparticles in Products Stored within Nanotechnology-Enabled Packaging

Yang

Paulose

Redan

et al. 2021

ACS Appl. Mater. Interfaces

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Nanotechnology-based packaging may improve food quality and safety, but packages manufactured with polymer nanocomposites (PNCs) could be a source of human dietary exposure to engineered nanomaterials (ENMs). Previous studies showed that PNCs release ENMs to foods predominantly in a dissolved state, but most of this work used food simulants like dilute acetic acid and water, leaving questions about how substances in real foods may influence exposure. Here, we demonstrate that food and beverage ingredients with reducing properties, like sweeteners, may alter exposure by inducing nanoparticle formation in foods contacting silver nanotechnology-enabled packaging. We incorporated 12.8 ± 1.4 nm silver nanoparticles (AgNPs) into polyethylene and stored media containing reducing ingredients in packages manufactured from this material under accelerated room-temperature and refrigerated conditions. Analysis of the leachates revealed that reducing ingredients increased the total silver transferred to foods contacting PNC packaging (by as much as 7-fold) and also induced the (re)formation of AgNPs from this dissolved silver during storage. AgNP formation was also observed when Ag+ was introduced to solutions of natural and artificial sweeteners (glucose, sucrose, aspartame), commercial beverages (soft drinks, juices, milk), and liquid foods (yogurt, starch slurry), and the amount and morphology of reformed AgNPs depended on the ingredient formulation, silver concentration, storage conditions, and light exposure. These results imply that food and beverage ingredients may influence dietary exposure to nanoparticles when PNCs are used in packaging applications, and the practice of using food simulants may in certain cases underpredict the amount of ENMs likely to be found in foods stored in these materials.

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“…Because of the antimicrobial potential of silver nanoparticles (AgNPs), they are amongst the most frequently used nanoparticles (NPs) in food associated products (e.g. packaging and kitchen utensils) (Choi et al 2018;Lichtenstein et al 2015). Therefore, oral ingestion is considered as a main exposure route for humans to AgNPs.…”

Section: Introductionmentioning

confidence: 99%

Impact of in vitro digestion on gastrointestinal fate and uptake of silver nanoparticles with different surface modifications

et al. 2019

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Nanomaterials, especially silver nanoparticles (AgNPs), are used in a broad range of products owing to their antimicrobial potential. Oral ingestion is considered as a main exposure route to AgNPs. This study aimed to investigate the impact of the biochemical conditions within the human digestive tract on the intestinal fate of AgNPs across an intestinal in vitro model of differentiated Caco-2/HT29-MTX cells. The co-culture model was exposed to different concentrations (250-2500 mg/L) of pristine and in vitro digested (IVD) AgNPs and silver nitrate for 24 h. ICP-MS and spICP-MS measurements were performed for quantification of total Ag and AgNPs. The AgNPs size distribution, dissolution, and particle concentration (mass-and number-based) were characterized in the cell fraction and in the apical and basolateral compartments of the monolayer cultures. A significant fraction of the AgNPs dissolved (86-92% and 48-70%) during the digestion. Cellular exposure to increasing concentrations of pristine or IVD AgNPs resulted in a concentration dependent increase of total Ag and AgNPs content in the cellular fractions. The cellular concentrations were significantly lower following exposure to IVD AgNPs compared to the pristine AgNPs. Transport of silver as either total Ag or AgNPs was limited (<0.1%) following exposure to pristine and IVD AgNPs. We conclude that the surface chemistry of AgNPs and their digestion influence their dissolution properties, uptake/association with the Caco-2/HT29-MTX monolayer. This highlights the need to take in vitro digestion into account when studying nanoparticle toxicokinetics and toxicodynamics in cellular in vitro model systems.

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Potential silver nanoparticles migration from commercially available polymeric baby products into food simulants

Cited by 21 publications

References 29 publications

Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure

Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure

Food and Beverage Ingredients Induce the Formation of Silver Nanoparticles in Products Stored within Nanotechnology-Enabled Packaging

Impact of in vitro digestion on gastrointestinal fate and uptake of silver nanoparticles with different surface modifications

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