Potential sources and sediment-pore water partitioning behaviors of emerging per/polyfluoroalkyl substances in the South Yellow Sea

Feng, Xuemin; Min-qiang, YE; Li, Yao; Zhou, Jian; Sun, Binbin; Zhu, Yumin; Zhu, Lingyan

doi:10.1016/j.jhazmat.2020.122124

Cited by 83 publications

(25 citation statements)

References 70 publications

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“…Poly/perfluoroalkyl substances (PFASs) are persistent organic pollutants which may pose a variety of risks to aquatic organisms . They are able to biomagnify and bioaccumulate in aquatic food webs, which are directly correlated to their chemical structures, e.g., carbon chain length. − Due to regulations and bans on some classical PFASs, e.g., perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) and their salts, short-chain PFASs and fluorotelomer-based PFASs are manufactured and applied as replacements for legacy PFASs, and their concentrations in the environment are increasing in the fresh surface water, coastal water, and tap water in many countries. − This raises awareness and concern about the potential risks of these PFASs in the environment. Polyfluoroalkyl phosphate diesters (diPAPs) are a group of novel PFASs used in water-based paints, cleaning products, floor polish solutions, and fast food packaging .…”

Section: Introductionmentioning

confidence: 99%

Thyroid-Disrupting Effects of 6:2 and 8:2 Polyfluoroalkyl Phosphate Diester (diPAPs) at Environmentally Relevant Concentrations from Integrated In Silico and In Vivo Studies

Pengyu

Yang

Chen

et al. 2020

Environ. Sci. Technol. Lett.

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Polyfluoroalkyl phosphate esters (PAPs), a kind of poly/perfluoroalkyl substance, are used in food contact materials. Herein, a three-dimensional quantitative structure–activity relationship (3D-QSAR) model was developed and applied to predict the binding affinity of 6:2 and 8:2 polyfluoroalkyl phosphate diesters (diPAPs) with transthyretin (ttr) to potentially displace thyroid hormones. The predicted activity of 6:2 diPAP was higher than that of 8:2 diPAP, and both were comparable to that of perfluorobutanesulfonate, suggesting their potential endocrine disrupting effects. For verification, zebrafish embryos were incubated with 6:2 and 8:2 diPAPs at 0.5–50 ng/L for 7 days. Both diPAPs reduced total and free thyroxine (T4) and triiodothyronine (T3) levels but elevated deiodinases levels, suggesting inhibited synthesis and increased metabolism of thyroid hormones. Consistent with the results of 3D-QSAR, the efficacy of 6:2 diPAP was generally higher than that of 8:2 diPAP, which might be due to the higher binding affinities of 6:2 diPAP for thyroid hormone receptor (TR) β and TTR, predicted by molecular docking. For both diPAPs, the decreased thyroid hormones weakened the activation of TRα, thus significantly reducing the TRα level in the intestine. The integrated results provide strong evidence of thyroid toxicities of 6:2 and 8:2 diPAPs.

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Section: Introductionmentioning

confidence: 99%

Thyroid-Disrupting Effects of 6:2 and 8:2 Polyfluoroalkyl Phosphate Diester (diPAPs) at Environmentally Relevant Concentrations from Integrated In Silico and In Vivo Studies

Pengyu

Yang

Chen

et al. 2020

Environ. Sci. Technol. Lett.

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“…2c and Table S7). Surface water will accelerate the migration of pollutants, and especially the supply also carries PFASs into groundwater (Chiavola et al 2020, Feng et al 2020. The PFOS substitute of F-53B was detected with low contamination degree, whereas concentration in surface water was higher in the groundwater.…”

Section: Heath Risk Assessmentmentioning

confidence: 99%

Occurrence and health risk assessment of perfluorinated substances from water in residential areas around fluorine chemical industry, China

Tang

Zhu

Liu

et al. 2021

Preprint

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To identify the contamination status and assess the health risk of per- and polyfluoroalkyl substances (PFASs) in surface and ground water are of great significance recently. Eighteen individual PFASs were analyzed in thirty-three surface/ground water samples from fluorine industry in one period of park-A (park A) and two periods of park B. All the short chain PFASs (C < 8) and chlorinated polyfluorinated ether sulfonate acid (F-53B) in the park A and B were detected with 100%. The first three detected substances of perfluorobutane sulfonate (PFBS), perfluorobutanoic acid (PFBA) and perfluorooctanoic acid (PFOA) were the predominant substances. The contamination status in wet season (WS) is stronger than in dry season (DS) in park B. Total concentration of PFASs(∑PFASs) in park A presented the increasing tendency following the groundwater flow direction whereas this rule was limited to reflect in all periods of park B. Applying different relative source contribution (RSC) of 100% and 20% to assess this risk of different aged group bodies from PFASs, the result was that all PFASs (4 ≤ C ≤ 7 or 9 ≤ C ≤ 12) while perfluorooctane sulfonate (PFOS) and PFOA (C = 8) were identified to the low risk quotient (RQ) contribution. Mixed RQmix value mainly relies on the PFOA and PFOS with a larger contribution rate of 80–90%. All assessed cases (Case 1, Case2, Case3 and Case4) to all aged groups reveal the infants were to be vulnerable to PFASs influence, followed by the children, teenagers and adults, respectively.

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“…Surprisingly, thus far, there is no mutually agreed international drinking water standard for PFOA and PFOS, but the United States Environmental Protection Agency have recommended a strict combined concentration limit of 70 ng/L (Cordner et al, 2019). Recent analysis of global water samples even revealed concentrations exceeding the provisional threshold (Andersson et al, 2019;Feng et al, 2020;Li et al, 2018;Lorenzo et al, 2019;Scher et al, 2018;Valsecchi et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Polymer-assisted modification of metal-organic framework MIL-96 (Al): influence of HPAM concentration on particle size, crystal morphology and removal of harmful environmental pollutant PFOA

Azmi

Ladewig

2021

Chemosphere

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Potential sources and sediment-pore water partitioning behaviors of emerging per/polyfluoroalkyl substances in the South Yellow Sea

Cited by 83 publications

References 70 publications

Thyroid-Disrupting Effects of 6:2 and 8:2 Polyfluoroalkyl Phosphate Diester (diPAPs) at Environmentally Relevant Concentrations from Integrated In Silico and In Vivo Studies

Thyroid-Disrupting Effects of 6:2 and 8:2 Polyfluoroalkyl Phosphate Diester (diPAPs) at Environmentally Relevant Concentrations from Integrated In Silico and In Vivo Studies

Occurrence and health risk assessment of perfluorinated substances from water in residential areas around fluorine chemical industry, China

Polymer-assisted modification of metal-organic framework MIL-96 (Al): influence of HPAM concentration on particle size, crystal morphology and removal of harmful environmental pollutant PFOA

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