Potential therapeutic applications of differentiated induced pluripotent stem cells (iPSCs) in the treatment of neurodegenerative diseases

Gao, Aijing; Peng, Yungui; Deng, Yulin; Qing, Hong

doi:10.1016/j.neuroscience.2012.09.076

Cited by 19 publications

(14 citation statements)

References 104 publications

(101 reference statements)

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“…Advancements in research with induced pluripotent stem cells (iPS), moreover, hold promise for the development of additional treatment options [2]. However, despite a growing body of evidence that stem cell-based strategies for patients with neurodegenerative diseases can be effective, there are many obstacles " If the implementation costs for stem cell-based treatments for neurodegenerative diseases cannot be reduced ... this emerging group of therapies may be affordable only to a smaller group of wealthy patients.…”

Section: Scientific Challengesmentioning

confidence: 99%

Stem Cell Treatments for Neurodegenerative Diseases: Challenges from a science, Business and Healthcare Perspective

Rosemann¹

2015

Neurodegener. Dis. Manag.

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Section: Scientific Challengesmentioning

confidence: 99%

Stem Cell Treatments for Neurodegenerative Diseases: Challenges from a science, Business and Healthcare Perspective

Rosemann¹

2015

Neurodegener. Dis. Manag.

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“…9). 177 Besides, tissue engineering may supply stable resource of tissue for in vitro use, including pathogenicity of diseases, pharmaceutical testing and so on.…”

Section: Applications In Tissue Engineering and Regenerative Medicinementioning

confidence: 99%

“…(3) Therapeutic agents screening: Effective chemical screening using various compounds to determine whether they enhance the function of neurodegenerative disease-specific iPSCs could provide candidate drugs that will be used in clinical trials and in animal models. Reprinted with permission from[177], A. Gao, et al, Potential therapeutic applications of differentiated induced pluripotent stem cells (iPSCs) in the treatment of neurodegenerative diseases.Neuroscience 228, 47 (2013). © 2013, Elsevier.…”

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confidence: 99%

The Role of Nanotechnology in Induced Pluripotent and Embryonic Stem Cells Research

Chen¹,

Qiu²,

Li³

2014

j biomed nanotechnol

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This paper reviews the recent studies on development of nanotechnology in the field of induced pluripotent and embryonic stem cells. Stem cell therapy is a promising therapy that can improve the quality of life for patients with refractory diseases. However, this option is limited by the scarcity of tissues, ethical problem, and tumorigenicity. Nanotechnology is another promising therapy that can be used to mimic the extracellular matrix, label the implanted cells, and also can be applied in the tissue engineering. In this review, we briefly introduce implementation of nanotechnology in induced pluripotent and embryonic stem cells research. Finally, the potential application of nanotechnology in tissue engineering and regenerative medicine is also discussed.

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“…39 All these applications hold great promise in the therapy of neurodegenerative disorders, such as Alzheimer's and Huntington's disease, in reproductive technology, or in the treatment of monogenic disease such as cystic fibrosis and sickle cell anemia. [40][41][42] However, the potential of iPS cells seems to be predominantly in regenerative medicine, and has already been proposed in cardiac repair, 43 ischemic stroke, 44 various neurological diseases 45 and diabetes. 46 Stem cellmediated therapy has also been proposed as a potential therapy for chronic diseases of a complex etiopathogenesis such as inflammatory bowel disease (IBD), although only the hematopoietic stem cells, 47,48 mesenchymal stem cells (MSCs) 49,50 and colonic stem cells 51 have been tested so far.…”

Section: Applicationsmentioning

confidence: 99%

In vivo reprogramming in inflammatory bowel disease

Wagnerová

Gardlík

2013

Gene Ther

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The direct reprogramming of somatic cells has immense implications in various areas of medicine. Although remarkable progress has been made in developing novel reprogramming methods, the efficiency and fidelity of reprogramming still need to be improved. Inflammatory bowel disease (IBD) involves chronic inflammatory diseases of the gastrointestinal tract with a complex etiology caused by various genetic, immunological and environmental factors. Recently, the role of stem cells has been proposed in pathogenesis and therapy of IBD. However, the efficiency and the safety of the stem cell treatments depend on the origin of the stem cell and the administration method. We hypothesize that the reprogramming of the intestinal cells into a pluripotent state is of huge importance for IBD therapy and prevention. The vectors carrying reprogramming genes encoding pluripotency factors can be transferred to the damaged tissue, in this case the intestine, by means of invasive bacterial vectors able to colonize colon mucosa. Reconstruction of tissues in vivo might avoid problems encountered in tissue rebuilding in vitro because of lack of appropriate scaffolds and microenvironments. Herein we present a review of recent literature and a perspective of in vivo reprogramming in IBD using bacterial vectors and analyze the rationale for such approach.

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Potential therapeutic applications of differentiated induced pluripotent stem cells (iPSCs) in the treatment of neurodegenerative diseases

Cited by 19 publications

References 104 publications

Stem Cell Treatments for Neurodegenerative Diseases: Challenges from a science, Business and Healthcare Perspective

Stem Cell Treatments for Neurodegenerative Diseases: Challenges from a science, Business and Healthcare Perspective

The Role of Nanotechnology in Induced Pluripotent and Embryonic Stem Cells Research

In vivo reprogramming in inflammatory bowel disease

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