Potential urinary monitoring of the enhanced permeability and retention effect using MMP-2-responsive poly(ethylene glycol) derivatives

Sun, Xiaohang; Nomoto, Takahiro; Takemoto, Hiroyuki; Matsui, Makoto; Guo, Hongbo; Sun, Yudi; Miura, Yutaka; Nishiyama, Nobuhiro

doi:10.1016/j.jconrel.2020.09.004

Cited by 13 publications

(6 citation statements)

References 32 publications

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“…What's more, the radiation can penetrate more deeply along with minimal absorbance in skins, tissues, and hemoglobin. [44] To avoid killing normal tissues, targeting groups are commonly decorated to PB NMs to form a targeted drug delivery system. In order to distinguish breast cancer cells, Shang et al [45] conjugated folic acid (FA) to PBNPs packaged in poly(lactic-coglycolic acid) (PLGA) to obtain a core/shell model for drugloading.…”

Section: Tumor Therapymentioning

confidence: 99%

“…Under the radiation of NIR light with the wavelength of 808 and 1024 nm, drugs could accumulate in tumor tissues through the enhanced permeability and retention effect (EPR). What's more, the radiation can penetrate more deeply along with minimal absorbance in skins, tissues, and hemoglobin [44] …”

Section: Biological Application Of Prussian Blue and Its Analoguementioning

confidence: 99%

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Prussian Blue and Its Analogues: From Properties to Biological Applications

Zeng,

Su,

Wang

et al. 2023

ChemistrySelect

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The utilization of metal organic framework (MOF) nanocomposites in various biomedical applications has been widely studied because of their unique properties. In recently years, Prussian blue (PB) is widely used in clinical studied due to its biosafety, which has already been approved by USA Food and Drug Administration (FDA). Therefore, it is great urgent to systematically summarize the resent progress to better serve the broad community of researchers. This review focuses on the properties of PB and PB analogues (PBA), and their applications in biological field. A systemic introduction of the properties is presented, including abilities of photothermal, scavenging of reactive oxygen species and adsorption. A variety of biomedical applications, such as tumor therapy, anti‐bacterial infection, biosensor, bioimaging, excretion, ischemic stroke treatment, etc. have been discussed as well. Furthermore, the challenges, key factors, and the prospects in the clinical transformation of PB or PBA are simultaneously discussed. This review will provide reference and guidance for the design and application of PB and PBA in the future.

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Section: Tumor Therapymentioning

confidence: 99%

Section: Biological Application Of Prussian Blue and Its Analoguementioning

confidence: 99%

Prussian Blue and Its Analogues: From Properties to Biological Applications

Zeng,

Su,

Wang

et al. 2023

ChemistrySelect

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“…Various types of MMPs-responsive nano systems have been developed both for diagnostic and therapeutic purposes in cancer (Table 1). For instance, a promising tool to predict the enhanced permeability and retention (EPR) effect in cancer patients has been recently developed using MMP-2-responsive PEG-NPs [233]. The EPR effect describes the preferential accumulation of nanomedicines or macromolecular drugs in the tumor sites, as a result of leaky vascular structures and dysfunctional lymphatic drainage, compared to normal tissues [234].…”

Section: Matrix Metalloproteinasesmentioning

confidence: 99%

“…The EPR effect describes the preferential accumulation of nanomedicines or macromolecular drugs in the tumor sites, as a result of leaky vascular structures and dysfunctional lymphatic drainage, compared to normal tissues [234]. MMP-2-responsive PEG-NPs have been conjugated with a fluorescent dye linked to a synthetic substrate that can be cleaved by MMP-2, which is overexpressed in the tumor ECM [233]. Upon tumor accumulation, the fluorescent dye is released from the PEG and excreted in the urine.…”

Section: Matrix Metalloproteinasesmentioning

confidence: 99%

Nano-targeting vascular remodeling in cancer: Recent developments and future directions

Giordo

Wehbe

Paliogiannis

et al. 2022

Seminars in Cancer Biology

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“…For EPR-based passive tumor targeting, it is also vital to reduce the clearance by the reticuloendothelial system (RES). NPs modified with hydrophilic groups such as polyethylene glycol, 18,19 cyclodextrins, 20 and zwitterions 21 can significantly escape the phagocytosis of the mononuclear macrophage system. Our previous work has shown that modification of zwitterions such as 1,3-propane sulfonate (1,3-PS), 2-methacryloyloxyethyl phosphorylcholine, and carboxymethylacrylamide on the surface of PAMAM dendrimers can endow them with improved antifouling property to boost therapeutic gene delivery and tumor multimodality imaging, thereby promoting the efficacy of the tumor theranostic effect.…”

Section: Introductionmentioning

confidence: 99%