Potential use of characterised hyper-colonising strain(s) of Campylobacter jejuni to reduce circulation of environmental strains in commercial poultry

Calderón-Gómez, Lirio I.; Hartley, Lauren E.; McCormack, Ashling; Ringoir, Danielle Desiree; Korolik, Victoria

doi:10.1016/j.vetmic.2008.09.055

Cited by 16 publications

(11 citation statements)

References 27 publications

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“…This is of interest as C. jejuni 331 is known to be a strong chicken coloniser, capable of out competing other C. jejuni strains in co-infection studies and has been proposed as a potential non-virulent bioreplacement bacteria [28,29]. It is possible that the lack of binding to disaccharide and small sugar subunits by C. jejuni 331 may offer a competitive advantage, allowing 331 to better colonise the intestinal crypts by ignoring smaller sugars in the lumen.…”

Section: Discussionmentioning

confidence: 99%

Assessment of glycan interactions of clinical and avian isolates of Campylobacter jejuni

et al. 2013

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BackgroundCampylobacter jejuni strain 11168 was demonstrated to have a broad specificity for eukaryotic surface glycosylation using glycan array analysis. The initial screen indicated that sialic acid and mannose are important binding partners after environmental stress, while galactose and fucose structures are likely to be involved in persistent infection.ResultsIn this broader study, five additional human/clinical isolates and six chicken isolates were fully assessed to determine their glycan binding capacity using an extended glycan array. C. jejuni 11168 was rescreened here due to the presence of glycoaminoglycan (GAG) and other structures that were not available on our previous glycan array. The current array analysis of additional C. jejuni strains confirmed the growth condition dependent differences in glycan binding that was previously observed for C. jejuni 11168. We noted strain to strain variations, particularly for the human isolates C. jejuni 520 and 81116 and the chicken isolate C. jejuni 331, with the majority of differences observed in galactose, mannose and GAG binding. Chicken isolates were found to bind to a broader range of glycans compared to the human isolates, recognising branched mannose and carageenan (red seaweed) glycans. Glycan array data was confirmed using cell-based lectin inhibition assays with the fucose (UEA-I) and mannose (ConA) binding lectins.ConclusionsThis study confirms that all C. jejuni strains tested bind to a broad range of glycans, with the majority of strains (all except 81116) altering recognition of sialic acid and mannose after environmental stress. Galactose and fucose structures were bound best by all strains when C. jejuni was grown under host like conditions confirming the likelihood of these structures being involved in persistent infection.

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Section: Discussionmentioning

confidence: 99%

Assessment of glycan interactions of clinical and avian isolates of Campylobacter jejuni

et al. 2013

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“…Theoretically this would mean that when nonpathogenic, strongly colonizing C. jejuni strains are identified, these strains can potentially be used to exclude pathogenic C. jejuni from broiler ceca. Calderon‐Gomez and others () identified a highly colonizing strain that could not be displaced by other colonizing strains. However, this measure does not take into account that Campylobacter species are capable of exchanging virulence properties (Zhou and others ) detrimental to humans with other Campylobacter species.…”

Section: Possible Intervention Measures To Delay or Prevent Campylobamentioning

confidence: 96%

Thermotolerant Campylobacter during Broiler Rearing: Risk Factors and Intervention

Robyn¹,

Rasschaert²,

Pasmans

et al. 2015

Comp Rev Food Sci Food Safe

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Thermotolerant Campylobacters are one of the most important bacterial causative agents of human gastrointestinal illness worldwide. In most European Union (EU) member states human campylobacteriosis is mainly caused by infection with Campylobacter jejuni or Campylobacter coli following consumption or inadequate handling of Campylobactercontaminated poultry meat. To date, no effective strategy to control Campylobacter colonization of broilers during rearing is available. In this review, we describe the public health problem posed by Campylobacter presence in broilers and list and critically review all currently known measures that have been researched to lower the numbers of Campylobacter bacteria in broilers during rearing. We also discuss the most promising measures and which measures should be investigated further. We end this review by elaborating on readily usable measures to lower Campylobacter introduction and Campylobacter numbers in a broiler flock.

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“…The mechanisms employed by the bacteria to colonize the chicken intestine are still not fully understood. Moreover, it was demonstrated that different C. jejuni strains do not have the same ability to colonize a chicken, with some strains outcompeting others when colonizing chicken cecum [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Extensive characterization of Campylobacter jejuni chicken isolates to uncover genes involved in the ability to compete for gut colonization

et al. 2015

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Background: Campylobacter jejuni is responsible for human foodborne enteritis. This bacterium is a remarkable colonizer of the chicken gut, with some strains outcompeting others for colonization. To better understand this phenomenon, the objective of this study was to extensively characterize the phenotypic performance of C. jejuni chicken strains and associate their gut colonizing ability with specific genes.

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Potential use of characterised hyper-colonising strain(s) of Campylobacter jejuni to reduce circulation of environmental strains in commercial poultry

Cited by 16 publications

References 27 publications

Assessment of glycan interactions of clinical and avian isolates of Campylobacter jejuni

Assessment of glycan interactions of clinical and avian isolates of Campylobacter jejuni

Thermotolerant Campylobacter during Broiler Rearing: Risk Factors and Intervention

Extensive characterization of Campylobacter jejuni chicken isolates to uncover genes involved in the ability to compete for gut colonization

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