Potential uses and benefits of phytosterols in diet: present situation and future directions

Quílez, Joan; Garcı́a-Lorda, Pilar; Salas‐Salvadó, Jordi

doi:10.1016/s0261-5614(03)00060-8

Cited by 176 publications

(120 citation statements)

References 86 publications

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“…For example, as functional food ingredients, they seem to be a safe and practical option to reduce cholesterol levels in the blood. They also exhibit cancer prevention activity as they exert cytotoxic effects on cancer cells (McCarthy et al, 2013;Quílez, García-Lorda, & Salas-Salvadó, 2003).…”

Section: Discussionmentioning

confidence: 99%

Bioactive compounds from brewer’s spent grain: phenolic compounds, fatty acids and in vitro antioxidant capacity

et al. 2017

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ABSTRACT. Brewer's spent grain (BSG) was characterized by physicochemical, total phenolic compound and flavonoids contents. Antioxidant activity was evaluated by four different assays. The chromatographic analyses were used to quantify the phenolic compounds and the fatty acids in BSG. Ethanolic extracts were tested to evaluate antibacterial activity. The higher concentration of total phenolic compounds for BSG was obtained in the extraction with ethanol 20%. BSG showed an antioxidant potential for all tests evaluated. In the case of chromatographic analysis, phenolic acids and flavonoids, such as syringic acid and catechin, respectively, were detected in high quantities. Regarding to the fatty acids profile, polyunsaturated fatty acids, such as linoleic and oleic acids, were found in significant amounts. No antibacterial activity was reported for bacterial cultures and concentrations tested. BSG may be considered a protein source, rich in fiber, polyunsaturated fatty acids and bioactive compounds with antioxidant potential.Keywords: by-products, brewer's spent grain, flavonoids, antioxidant.Compostos bioativos do bagaço de malte: compostos fenólicos, ácidos graxos e capacidade antioxidante in vitro RESUMO. Bagaço de malte (BM) foi caracterizado pela avaliação do conteúdo total de compostos fenólicos e flavonóides e propriedades físico-químicas. A atividade antioxidante foi avaliada por quatro diferentes ensaios. Análises cromatográficas foram utilizadas para quantificar os compostos fenólicos e os ácidos graxos do BM. O extrato etanólico foi testado para avaliar a atividade antibacteriana. A concentração mais elevada de compostos fenólicos totais para o BM foi obtida na extração com etanol a 20%. O BM mostrou um potencial antioxidante para todos os testes avaliados. Na análise cromatografia líquida, ácidos fenólicos e flavonóides, tais como o ácido siringico e catequina, respectivamente, foram detectados em quantidades elevadas. Em relação ao perfil de ácidos graxos, ácidos graxos poli-insaturados, como ácidos oleico e linoleico, foram encontradas em quantidades significativas. Nenhuma atividade antibacteriana foi observada para culturas de bactérias e concentrações testadas. BM pode ser considerado como uma fonte de proteína, rico em fibra, ácidos graxos poli-insaturados e compostos bioativos com potencial antioxidante.Palavras-chave: sub-produto, bagaço de malte, flavonoides, antioxidante.

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Section: Discussionmentioning

confidence: 99%

Bioactive compounds from brewer’s spent grain: phenolic compounds, fatty acids and in vitro antioxidant capacity

et al. 2017

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“…Indeed, sterols possess properties of reducing cholesterol levels in blood serum [14], some phenolic compounds have recognized antioxidant activity used in the food industry as well as other effects of the type anti-allergic, anti-artherogenic, anti-inflammatory, antimicrobial, vasodilatant, etc. [15].…”

Section: Extractives Of Miscanthus X Giganteusmentioning

confidence: 99%

Miscanthus x giganteus as a Source Of Biobased Products Through Organosolv Fractionation: A Mini Review

Villaverde¹,

Ligero²,

Vega

2010

TOASJ

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This paper deals with the chemical treatments with selected organic compounds that have been applied to Miscanthus to upgrade it, for pulp production or fractionation purposes. Organosolv processes have demonstrated their effectiveness as fractionation treatments; therefore special emphasis is placed on these systems and, in particular, those making use of carboxylic acids. That is, Acetosolv process that uses acetic acid-water-hydrochloric acid mixtures as delignifying agents, the process with formic acid-water-hydrochloric acid and the Milox process, which replaces the hydrochloric acid in the medium by hydrogen peroxide, thus forming peroxyacetic acid. Furthermore, we present the results of the characterizations that have been made in relation to extractives and lignin of Miscanthus. It also is analyzed the major changes undergone by lignin during organosolv treatments. Finally, some progresses in the field of TCF bleaching of the cellulose pulps obtained are summarized.

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“…The intake of 2 g per day of PS reduces low-density lipoprotein cholesterol (LDL-C) by an average of 10% (Katan et al, 2003). PS and stanols are recommended as therapeutic lifestyle changes to reduce LDL-C (QuIlez et al, 2003). PS mediate their cholesterol-lowering effect by inhibiting intestinal cholesterol absorption (Moreau et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Baseline plasma plant sterol concentrations do not predict changes in serum lipids, C-reactive protein (CRP) and plasma plant sterols following intake of a plant sterol-enriched food

et al. 2007

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Background/Objectives: Plant sterol (PS) consumption lowers serum cholesterol levels, while modestly increasing plasma PS concentrations. Plasma PS concentrations may reflect sterol absorption, thus individuals with high plasma plant sterol (HPS) concentrations may show greater changes in circulating cholesterol and PS than individuals with low plasma plant sterol (LPS) concentrations. The objective of this study was to examine whether HPS and LPS concentrations are related to subsequent changes in plasma PS, serum lipid and C-reactive protein (CRP) concentrations, following dietary PS intake in otherwise healthy hypercholesterolemic men. Subjects/Methods: This single-blinded, randomized, diet-controlled study consisted of two 4-week phases, separated by a 4-week washout, where a diet with a placebo or the 2.0 g per day PS-enriched spread was consumed during the phases. Results: At baseline, men with HPS possessed higher (Po0.01) mean serum cholesterol concentration, while those with LPS had higher (Po0.05) body mass index. Following PS intake, plasma sum of campesterol plus sitosterol concentrations were elevated from 34.6±4.2 to 46.2±3.3 mmol l À1 (mean±SE) and 16.5±0.9 to 20.8±1.2 mmol l À1 after PS intake in men with HPS and LPS, respectively. Changes in plasma PS concentrations, however, were not different between individuals with either HPS or LPS baseline concentrations. Total cholesterol and low-density lipoprotein cholesterol levels were decreased (Po0.0001) by 6.3 and 7.8%, respectively, with PS consumption for all individuals. Changes in lipid parameters were not different between individuals with HPS or LPS baseline concentrations. No changes in CRP were apparent subsequent to PS intervention. Conclusions: Baseline plasma PS concentrations are not associated or predictive of changes in serum cholesterol or plasma PS concentrations after PS intervention. Thus, individuals with HPS show similar increases in PS concentrations as individuals with LPS following PS supplementation. Plasma PS remained in the range of previously reported concentrations.

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Potential uses and benefits of phytosterols in diet: present situation and future directions

Cited by 176 publications

References 86 publications

<b>Bioactive compounds from brewer’s spent grain: phenolic compounds, fatty acids and <i>in vitro</i> antioxidant capacity

<b>Bioactive compounds from brewer’s spent grain: phenolic compounds, fatty acids and <i>in vitro</i> antioxidant capacity

Miscanthus x giganteus as a Source Of Biobased Products Through Organosolv Fractionation: A Mini Review

Baseline plasma plant sterol concentrations do not predict changes in serum lipids, C-reactive protein (CRP) and plasma plant sterols following intake of a plant sterol-enriched food

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