Potential Value of Estrogen Receptor Beta Expression in Colorectal Carcinoma: Interaction with Apoptotic Index

Elbanna, Hosam Ghazy; Ebrahim, Mohamed A.; Abbas, Amr M.; Zalata, Khaled; Hashim, Maha Abo

doi:10.1007/s12029-010-9214-4

Cited by 25 publications

(25 citation statements)

References 32 publications

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“…Results of our study are in line with studies that associated ER β -negative tumours with advanced tumour stages (Jassam et al , 2005; Elbanna et al , 2012). We did not observe a significantly different expression of ER β in relation to tumour differentiation as reported by Konstantinopoulos et al (2003).…”

Section: Discussionsupporting

confidence: 93%

“…On the other hand, the ER α , which has a major role in breast cancer development (Cuzick et al , 2011), treatment and prognosis (Davies et al , 2011), can be found only at very low levels in normal colorectal tissue (Kennelly et al , 2008). Results of previous studies showed that loss of ER β expression in CRC is associated with poorer differentiation of tumours and more advanced cancer stages (Konstantinopoulos et al , 2003; Jassam et al , 2005; Elbanna et al , 2012). …”

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confidence: 96%

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Expression of oestrogen receptor β and prognosis of colorectal cancer

et al. 2012

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Background:Previous studies suggest that sex steroids influence colorectal cancer (CRC) carcinogenesis. The oestrogen receptor β (ERβ) is the predominantly expressed ER in the colon and loss of ERβ in CRC has been associated with advanced cancer stages.Methods:Information on vital status by the end of 2009 was obtained for 1262 CRC patients recruited between 2003 and 2007. The ERβ expression was immunohistochemically measured and associations of ERβ scores with overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS) were evaluated using Cox proportional hazard models adjusted for prognostic factors, such as tumour stage and second primary tumours.Results:Of the 1101 tumour samples with successful measurement, 535 were ERβ negative (48.6%), 381 (34.6%) showed moderate and 185 (16.8%) showed high ERβ expression. Compared with high ERβ expression, lack of ERβ was associated with higher cancer stages as well as greater tumour extent. In multivariate analyses, ERβ negativity was associated with an increased hazard ratio for death (HR=1.61, 95% CI 1.09–2.40, P=0.02), death attributed to CRC (HR=1.54, 95% CI 0.99–2.39, P=0.06) as well as a poorer DFS (DFS HR=1.64, 95% CI 1.23–3.36, P=0.04). The associations were stronger in stage I-III patients (OS HR=2.20, 95% CI 1.28–4.06, P=0.007, DSS HR=2.38, 95% CI 1.20–5.39, P=0.02, respectively).Conclusions:Lack of ERβ expression is associated with advanced cancer stages and independently associated with poor survival.

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Section: Discussionsupporting

confidence: 93%

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confidence: 96%

Expression of oestrogen receptor β and prognosis of colorectal cancer

et al. 2012

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“…ERβ has a crucial role in colonic-cell homeostasis, including modulation of proliferation and organised cell death (Kennelly et al, 2008). Some previous studies have showed that loss of ERβ expression in CRC is associated with poorer differentiation of tumors and more advanced cancer stages (Jassam et al, 2005;Elbanna et al, 2012). And a previous study demonstrated that ERβ-positive colorectal tumors were associated with a better overall survival (Fang et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Distribution Characteristics of 3,369 Chinese Colorectal Cancer Patients for Gender, Age, Location and Tumor Size During Colonoscopy

Cai

Wang²,

Liao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Studies have shown the existence of gender-and age-related differences in the incidence and anatomic distribution of colorectal cancers. The purposes of this study were to analyze the distribution characteristics of colorectal cancer patients regarding gender, age, location and tumor size in the course of colonoscopy. Materials and Methods: All colorectal cancer patients who underwent colonoscopy in the First Affiliated Hospital of Guangxi Medical University from 2003 to 2012 were included in our retrospective study. Demographic information (age and gender) and colonoscopy report information (tumor size and location) were collected and analyzed. To compare the gender differences in tumor location and tumor size, as well as the size differences in tumor location, the chi-square test was used. Results: A total of 3, 369 colorectal cancer patients (2, 007 men vs 1, 362 women) were included in our study. Statistical analysis showed there was no gender difference in the anatomic distribution of the tumors (p>0.05). However, there was a gender difference in tumor size (p<0.05). In addition, our study found there was a significant difference in tumor size between rectal and colon tumors (p<0.001). Conclusions: There was no gender difference in the anatomic distribution of colorectal tumors. In addition, tumors observed in men were larger than in women.

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“…A potential mediator of estrogen effects is the estrogen receptor-b (ESR2), which is the primarily expressed estrogen receptor in the large intestine (1). Loss of ESR2 expression in tumor tissue of patients with colorectal cancer has been associated with poorer differentiation of tumors and more advanced cancer stages (7)(8)(9)(10). However, it has also been postulated that endogenous and exogenous sex hormones may have differential effects on the development of colorectal cancer (6), as high levels of endogenous estrogens have been found to be associated with an increased risk for colorectal cancer (11,12).…”

Section: Introductionmentioning

confidence: 99%

Colorectal Cancer Risk Associated with Hormone Use Varies by Expression of Estrogen Receptor-β

et al. 2013

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The risk of colorectal cancer is reduced among users of oral contraceptives or menopausal hormone therapy, but associations with reproductive characteristics that are markers of a woman's endogenous hormone milieu have not been consistently observed. To help understand possible mechanisms through which exogenous and endogenous hormonal exposures are involved in colorectal cancer, we assessed the risk of these malignancies according to tumor expression of estrogen receptor-b (ESR2). In a population-based study of postmenopausal women (503 cases and 721 controls matched for sex and age), immunohistochemical expression of ESR2 was determined in 445 cases of incident colorectal cancer. Unconditional logistic regression was used in case-case analyses to assess heterogeneity between risk associations according to ESR2 status and in case-control analyses to estimate associations separately for ESR2-negative and ESR2-positive tumors. For ESR2-positive tumors but not ESR2-negative tumors, colorectal cancer risk significantly decreased with duration of oral contraceptive use [per five-year increments OR ESR2-positive, 0.87, 95% confidence interval (CI), 0.77-0.99; OR ESR2-negative, 1.02, 95% CI, 0.91-1.15; P heterogeneity ¼ 0.07] and with duration of menopausal hormone therapy use (per five-year increments OR ESR2-positive, 0.84, 95% CI, 0.74-0.95; OR ESR2-negative, 0.94, 95% CI 0.84-1.05; P heterogeneity ¼ 0.06). Significant heterogeneity according to ESR2 expression was found for the association with current use of menopausal hormone therapy (<0.5 years ago; P heterogeneity ¼ 0.023) but not for associations with reproductive factors. In conclusion, our results suggest that hormone use decreases risk for ESR2-positive but not ESR2-negative colorectal cancer. Cancer Res; 73(11); 3306-15. Ó2013 AACR.

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Potential Value of Estrogen Receptor Beta Expression in Colorectal Carcinoma: Interaction with Apoptotic Index

Cited by 25 publications

References 32 publications

Expression of oestrogen receptor β and prognosis of colorectal cancer

Expression of oestrogen receptor β and prognosis of colorectal cancer

Distribution Characteristics of 3,369 Chinese Colorectal Cancer Patients for Gender, Age, Location and Tumor Size During Colonoscopy

Colorectal Cancer Risk Associated with Hormone Use Varies by Expression of Estrogen Receptor-β

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