Potential Value of Plants as Sources of New Antifertility Agents II *

Farnsworth, Norman R.; Bingel, Audrey S.; Cordell, Geoffrey A.; Crane, F.A.; Fong, Harry H. S.

doi:10.1002/jps.2600640504

Cited by 263 publications

(75 citation statements)

References 373 publications

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“…have been found to exert antifertility effect in experimental rats (Farnsworth et al 1975;Ammar et al 2003;Benariba et al 2013). The mechanism by which these antifertiliy properties were exerted is, however, different among the different species.…”

Section: Herbal Remedies With Female Antifertility and Abortificiant mentioning

confidence: 99%

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Akour

Kasabri

Afifi

et al. 2016

Pharmaceutical Biology

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Context National statistical reports in Jordan indicate a decrease in the total fertility rate along with a parallel increase in contraceptive use. The folkloric use of medicinal herbs in gynecological disorders has been growing in Jordan, despite of deficient reports on the evidence-based safety and efficacy of these practices. Objective The aim of this comprehensive article is to review medicinal plants with claimed ethnonpharmacological usage in various gynecological and pregnancy-related issues in Jordan, and to assess their evidence-based pharmacological studies as well as their phytochemistry. Methods The published literature was surveyed using Google Scholar entering the terms ''ethnopharmacology AND Jordan AND infertility AND gynecology OR gestation''. We included ethnopharmacological surveys in Jordan with available full-text. Results Twelve articles were reviewed. Plant species which are commonly used for female gynecological issues such as Artemisia monosperma Del. and A. herba-alba Asso. (Asteraceae) have been found to exert an antifertility effect. Ricinus communis L. (Euphorbiaceae) and Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) had antifertility effects in male rats, but Nigella sativa oil L. (Ranunculaceae) and Cinnamon zeylanicum J. Presl (Lauraceae) were found to enhance it. Conclusion Using plants for gynecological disorders is a common practice in Jordan. Many of them, whether utilised for gynecological or non-gynecological conditions equally, were found to have detrimental effects on female or male fertility. Thus, couples planning pregnancy should be discouraged from the consumption of these herbs. Further local studies are warranted to confirm the appreciable beneficial pharmacological effects and safety of these plants. ARTICLE HISTORY

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Section: Herbal Remedies With Female Antifertility and Abortificiant mentioning

confidence: 99%

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Akour

Kasabri

Afifi

et al. 2016

Pharmaceutical Biology

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“…Plants (57) and fungal contaminants of stored grain (58) contain estrogens that are suspected of contributing to infertility problems in farm animals. There is also the possibility that phytoestrogens in the diet can contribute to the growth of hormone-dependent breast tumors in postmenopausal patients (59).…”

Section: Phytoestrogensmentioning

confidence: 99%

Structure-Activity Relationships of Estrogens

Jordan¹,

Mittal²,

Gosden³

et al. 1985

Environmental Health Perspectives

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The last 50 years has seen an exponential rise in the published reports about estrogen action. The model to describe the early events in the mechanism of action of estrogens via the estrogen receptor is updated in this paper to incorporate some of the recent data on the subcellular localization of the receptor. New evidence suggests that the receptor is a nuclear protein, so it appears that estrogens must first diffuse into the nuclear compartment to initiate estrogen action via the receptor complex. This review traces the development of potent estrogenic compounds by the study of their structure-activity relationships. Studies of structure-activity relationships in vivo using Allen Doisy or 3-day uterine weight tests can provide much valuable information, but the assays suffer from the complex problems of pharmacokinetics and metabolic transformation. Studies in vitro using primary cultures of rat pituitary or uterine cells to assay the ability of a compound to induce prolactin synthesis or progesterone receptor synthesis, respectively, can provide essential information about the structural requirements for a compound to produce estrogenic effects. Nevertheless, it should be pointed out that studies in vivo are required to determine whether a compound is metabolically activated to an estrogen. Estrogen receptor binding models are presented to describe the changes in a molecule that will predict high affinity for the ligand and agonist, partial agonist and antagonist properties of the ligand-receptor complex. Most estrogenic pesticides and phytoestrogens comform to the predictions of the estrogen receptor binding model.

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“…1926 wurde erstmals beschrieben, dass Pflanzen östrogenähnliche Aktivität ausüben können [33]. 1975 wurden mehrere hundert Pflanzen mit östro-genähnlicher Aktivität identifiziert [22]. Epidemiologische Studien weisen darauf hin, dass der Konsum einer phytoöstrogen-reichen Diät, wie sie in traditionellen asiatischen Kulturen praktiziert wird, mit einem niedrigeren Risiko für sog.…”

Section: Geschichteunclassified

Phytoöstrogene als Antiaging-Mittel

Keil¹,

Bayerl²

2002

Akt Dermatol

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EinleitungDie Menschen werden immer älter, aber alle wollen jünger bleiben. Die Haut ist das Organ, das dem Altern am sichtbarsten unterworfen ist, wobei zahlreiche endogene und exogene Faktoren die natürlichen Alterungsvorgänge beschleunigen können. Umgangssprachlich sagt man, die Haut sei ein Spiegel der Gesundheit. Während in der Renaissance die Maler Schönheit als Korpulenz und blasse Haut als schön ansahen (Abb. AbstractIt is a well-known fact that the desire for beauty has always occupied mankind. According to the ideal of beauty, the most different methods for improvement of the appearance were carried out. The increasing portion of elderly people of the population with consecutive intrinsic and extrinsic skin aging gives this situation a special dynamics. Next to the beauty ideal preventive and curative measures during these life decades receive a prerogative meaning. The numerous positive effects of estrogen therapy in women are well-known, whereby there is more and more evidence that anti-aging effects occur through estrogen intake. Phytoestrogens derive from plants and have an estrogen-like effectiveness. Lately, creams containing phytoestrogens with the isoflavonoid compounds genistein and daidzein have been used for wrinkle-reduction. In this overview the actual knowledge regarding phytoestrogens is presented. Übersicht 69Dieses Dokument wurde zum persönlichen Gebrauch heruntergeladen. Vervielfältigung nur mit Zustimmung des Verlages.

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Potential Value of Plants as Sources of New Antifertility Agents II *

Cited by 263 publications

References 373 publications

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Structure-Activity Relationships of Estrogens

Phytoöstrogene als Antiaging-Mittel

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