Linear atrophoderma of Moulin is a distinctive disease originally described in 1992 and characterized by acquired, mildly atrophic, non-sclerotic, slightly hyperpigmented lesions following the lines of Blaschko. Here, we describe a 15-year-old girl with a 13-year history and a 29-year-old male with a 6-year history of prominent linear telangiectatic erythema and mild atrophoderma following the lines of Blaschko that involved the right leg and hip, and both legs, the trunk and both arms, respectively. As pronounced telangiectatic erythema within lesions of atrophoderma of Moulin has not hitherto been described, we propose that the disease in our patients represents a novel variant of linear atrophoderma of Moulin. Due to considerable overlap, we do not favour the notion that our cases constitute an entity entirely separate from linear atrophoderma of Moulin.

EinleitungDie Menschen werden immer älter, aber alle wollen jünger bleiben. Die Haut ist das Organ, das dem Altern am sichtbarsten unterworfen ist, wobei zahlreiche endogene und exogene Faktoren die natürlichen Alterungsvorgänge beschleunigen können. Umgangssprachlich sagt man, die Haut sei ein Spiegel der Gesundheit. Während in der Renaissance die Maler Schönheit als Korpulenz und blasse Haut als schön ansahen (Abb. AbstractIt is a well-known fact that the desire for beauty has always occupied mankind. According to the ideal of beauty, the most different methods for improvement of the appearance were carried out. The increasing portion of elderly people of the population with consecutive intrinsic and extrinsic skin aging gives this situation a special dynamics. Next to the beauty ideal preventive and curative measures during these life decades receive a prerogative meaning. The numerous positive effects of estrogen therapy in women are well-known, whereby there is more and more evidence that anti-aging effects occur through estrogen intake. Phytoestrogens derive from plants and have an estrogen-like effectiveness. Lately, creams containing phytoestrogens with the isoflavonoid compounds genistein and daidzein have been used for wrinkle-reduction. In this overview the actual knowledge regarding phytoestrogens is presented. Übersicht 69Dieses Dokument wurde zum persönlichen Gebrauch heruntergeladen. Vervielfältigung nur mit Zustimmung des Verlages.

Objective: To evaluate, in the context of a randomized study, the ‘Sole Si Sole No GISED’ project, the effectiveness of an educational intervention to improve sun protection behaviour in schoolchildren. Methods: A large number of primary schools (classes II and III) in Italy were randomized to an educational intervention or control group: The intervention was conducted by trained teachers using ad hoc developed materials. Attitudes toward sun exposure and behaviour while in the sun were assessed at baseline and 1 year after concluding the educational intervention. In a subgroup of children, melanocytic naevi were counted on the upper limbs at the same intervals. The pilot phase of the study was started in 2001. Results: During the pilot phase, a total of 4,233 children was recruited. Of these, 2,116 were randomized to the active intervention and 2,117 to the control group. No difference for any of the study variables was documented between the 2 groups at baseline. About 20% of the children reported intense sun exposure during the year preceding the study. About 88% of the children reported adequate modalities of sun protection. Sunscreens were commonly used. A total of 508 children (12%) reported a history of sunburns in the year preceding the start of the study. Melanocytic naevi were counted in a total of 1,503 children (852 in the experimental and 651 in the control group). No differences in terms of skin, hair and eye colours were documented between the experimental and the control groups. The mean naevus count at baseline was 9.6 (median 7) in the experimental group and 10.1 (median 8) in the control group. Conclusion: About 50% of the total expected number of children was recruited during the pilot phase of the study. Randomization proved to be an excellent modality to select 2 samples similar for all the important study variables examined. A history of sunburns was reported less frequently than expected. The ‘Sole Si Sole No GISED programme’ is one of the few examples of a controlled evaluation of the effectiveness of an educational intervention in Italy.

EinleitungHäufigere Operationen kleineren Ausmaßes in der Dermatologie bringen die Haut mit potenziellen Allergenen in Kontakt. Es be− steht das Risiko einer Sensibilisierung auf den OP−Faden, die Lo− kalanästhetika, die Desinfektionsmittel, die Wundspüllösungen und das Schutzpflaster nach der Wundschließung. Werden Nä− vuszellennävi und andere Hautveränderungen regelmäßig ent− fernt, kann sich die Zahl der Eingriffe schnell zu 30 bis 40 Klein− operationen summieren. Kennt der Patient seine Pflasterunver− träglichkeit, macht er in der Regel schon vorher darauf aufmerk− sam. Werden Lokalanästhetika nicht vertragen, berichtet der Pa− tient meistens über Vorfälle bei der Zahnbehandlung. Zu allergi− schen oder irritativen Reaktionen auf Desinfektionsmittel erhält man selten eine Auskunft. Noch geringer ist die Zahl der beob− achteten Unverträglichkeiten auf das millionenfach eingesetzte synthetische Nahtmaterial. AbstractA 42−year−old female kindergarden teacher developed an erythe− ma around the operation field lasting for several days. To remove multiple nevus cell nevi from her skin, 27 surgical operations had been performed during the last years. As the suture came under suspicion another colourless thread was used in the next opera− tion. However the erythema developed again. Epicutaneous tests were done with all operation and auxiliary materials used before and at the last surgery. In the 72 hour reading 3+−plus reactions were observed due to the azo dye acid blue 158 of the thread, ge− nuine colophony and modified colophony products whereas 2+ −plus reactions were seen with povidone iodine and prilocaine. It became clear that specific hypersensitivity to these five allergens had been induced solely by frequent contact with protecting plas− ters containing colophony, the azo dye of the surgical suture, po− vidone iodine used for disinfection and the numerous subcutane− ous applications of the local anaesthetic prilocaine. The latter must have been responsible for the second relapse because the thread used during the last operation contained no dye. Kasuistik 458Dieses Dokument wurde zum persönlichen Gebrauch heruntergeladen. Vervielfältigung nur mit Zustimmung des Verlages.

ZusammenfassungIn einer offenen kontrollierten Anwendungsbeobachtung über 3 Wochen wurde an 30 Probanden mit empfindlicher Haut (objektiviert mittels positivem Stinging-Test) ein Deodorant auf Hautverträglichkeit getestet. Aufgrund der Tatsache, dass man mit apparativen Methoden axillär nicht objektive Messergebnisse erzielen kann, wurde in dieser Testung auf den linken Unterarm ausgewichen, an dem das Testpräparat zur Beurteilung und Objektivierung der Verträglichkeit getestet wurde. An beiden Unterarmen wurden die hautphysiologischen Parameter pH-Wert, Hautfeuchtigkeit, Fettgehalt des Stratum corneums und transepidermaler Wasserverlust (TEWL) gemessen. Zudem wurde das Testpräparat täglich axillär angewandt. Bei subjektiver Verträglichkeit axillär konnten im Beobachtungszeitraum bei tägli-cher Anwendung der Testsubstanz keine irritativen Hautverän-derungen oder Störungen der Barrierefunktion des Stratum corneums bei der Überprüfung am Unterarm festgestellt werden. Das Testprodukt hatte keinen signifikanten Einfluss auf die Hautfeuchtigkeit, den Fettgehalt und den transepidermalen Wasserverlust des Stratum corneums. Der pH-Wert sank am linken Unterarm unter Verwendung des Deodorants signifikant ab, blieb jedoch im physiologischen Bereich von ca. pH 5,5. Die Testung am Unterarm stimmte mit der guten Verträglichkeit axillär über-ein. Somit hatte das Testprodukt keine schädigenden Auswirkungen auf die Hornschichtbarriere und kann aufgrund dieser Ergebnisse zu Wirksamkeit und Verträglichkeit zur täglichen Pflege bei sensibler Haut empfohlen werden. AbstractIn an open controlled study the application of a deodorant for 3 weeks was tested for tolerance in 30 volunteers with sensitive skin (positive stinging test). As axillar measurement leads to no objective results, the left forearm was chosen for testing where the test product was applied. Additionally, the deodorant was applied to both axillae. The parameters pH, skin capacity, lipid content of the stratum corneum and transepidermal water loss were measured on the left and right forearm. During the observation period no irritative changes or damages of the skin barrier could be observed by using the deodorant regularly. The application of the deodorant had no significant influence on skin capacity, the skin lipid content and the transepidermal water loss. After 3 weeks the pH-value decreased significantly on the left forearm but remained in the physiologic range of approximately pH 5.5. The test results correlated to the subjectively evaluated good tolerance in the axillar location. These excellent results recommend the tested product for the daily care of sensitive skin.