Potentially inappropriate medication use in elderly patients

Harugeri, Anand; Joseph, Jinta; Parthasarathi, G; Ramesh, Madhan; Guido, Shoba

doi:10.4103/0022-3859.68642

Cited by 56 publications

(36 citation statements)

References 26 publications

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“…The prevalence of prescription of PIMs independent of diagnoses or condition (59.3%) was higher than that reported in other studies employing similar methods (14,16,17,26,28) The high frequency of prescription of PIMs may reflect the lack of knowledge regarding the Beers Criteria among prescribers. This reinforces the importance of the dissemination of the Beers Criteria among physicians, and the implementation of prescription review.…”

Section: Resultscontrasting

confidence: 50%

“…The prevalence of polypharmacy among the hospitalized elderly was high (90.2%) and similar to the rate detected in a study conducted in India (90.4%) but higher than the prevalence identified in an Italian study (20.1%) (27,28). Polypharmacy exposes elderly patients to a greater likelihood of drug-related problems (or drug therapy problems), adverse reactions and drug interactions (8).…”

Section: Resultssupporting

confidence: 48%

“…The most frequently prescribed PIMs in this study, namely, the long-acting benzodiazepine diazepam, digoxin, scopolamine and short-acting nifedipine, also featured among the five most prescribed PIMs of other similar studies (16,17,26,28). These results demonstrate that hospitalized elderly may be at greater risk of ADRs such as constipation, orthostatic hypotension, sedation, walking difficulties, falls and fractures (18,19).…”

Section: Resultsmentioning

confidence: 82%

“…This shows that, although patients hospitalized for longer periods are believed to be more fragile, no additional efforts were made to safeguard them from the potential harm of polypharmacy and PIM use. Likewise, several other studies also found an association between longer lengths of stay and PIM use (17,26,28).…”

Section: Resultsmentioning

confidence: 99%

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Potentially Inappropriate Medication Use Among Older Hospitalized Patients in a Brazilian General Hospital

Silva

Pereira

Soares

et al. 2016

Infarma

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Potentially inappropriate medication use among elderly patients from a Brazilian general hospital Uso de medicamentos potencialmente inadequados entre idosos em um hospital geral brasileiro ABSTRACTThe aim of this study was to determine the profile of the pharmacotherapy used by hospitalized elderly. A cross-sectional study was conducted at a Brazilian charitable general hospital. Drug prescriptions for hospitalized elderly patients (age≥60 years), dated from May to September 2010, were the source of data for this study and retrospectively analyzed (n=1,783). Polypharmacy (use of 5 or more drugs) and potentially inappropriate medications (PIMs -according to the Beers Criteria) were identified. Associations between sex, age, admission for cardiovascular disease or hospital stay and polypharmacy or PIM prescription were studied using univariate analysis (Pearson's Chi-square test). The association between polypharmacy and PIM prescription was also evaluated. A total of 204 elderly were hospitalized (mean age = 75 years) during the study period. The most commonly prescribed drugs acted on the cardiovascular system (29%) and the alimentary tract and metabolism (26%). Around 90% of the elderly were submitted to polypharmacy and 59% had, at least, one prescription of PIMs. A hospital stay of five days or more was associated with polypharmacy and PIM prescription. This study revealed a worrying drug utilization profile of high PIM use and polypharmacy practice. There is a need to implement strategies to improve geriatric prescribing.

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Section: Resultscontrasting

confidence: 50%

Section: Resultssupporting

confidence: 48%

Section: Resultsmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Potentially Inappropriate Medication Use Among Older Hospitalized Patients in a Brazilian General Hospital

Silva

Pereira

Soares

et al. 2016

Infarma

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“…[3] Benzodiazepines, antihistamines, anticholinergics, and cardiac glycosides are the commonly prescribed inappropriate medicines among geriatric patients. [45]…”

Section: Introductionmentioning

confidence: 99%

Utilization of potentially inappropriate medications in elderly patients in a tertiary care teaching hospital in India

Jhaveri

Patel

Barvaliya³

et al. 2014

Perspect Clin Res

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Aim:To evaluate the use of potentially inappropriate medicines in elderly inpatients in a tertiary care teaching hospital.Materials and Methods:Retrospective analysis was performed for cases of elderly patients admitted between January 2010 and December 2010. Data on age, gender, diagnosis, duration of hospital stay, treatment, and outcome were collected. Prescriptions were assessed for the use of potentially inappropriate medications in geriatric patients by using American Geriatric Society Beer's criteria (2012) and PRISCUS list (2010).Results:A total of 676 geriatric patients (52.12% females) were admitted in the medicine ward. The average age of geriatric patients was 72.69 years. According to Beer's criteria, at least one inappropriate medicine was prescribed in 590 (87.3%) patients. Metoclopramide (54.3%), alprazolam (9%), diazepam (8%), digoxin > 0.125 mg/day (5%), and diclofenac (3.7%) were the commonly used inappropriate medications. Use of nonsteroidal anti-inflammatory drugs (NSAIDs) in heart and renal failure patients was the commonly identified drug–disease interaction. According to PRISCUS list, at least one inappropriate medication was prescribed in 210 (31.06%) patients.Conclusion:Use of inappropriate medicines is highly prevalent in elderly patients.

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Population‐based prevalence of polypharmacy and patterns of medication use in southwestern Iran: A cross‐sectional study

Taherifard

Mohammadi

Vardanjani

et al. 2022

Pharmacoepidemiology and Drug

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Background: Pharmaceutical medications are considered an important component of healthcare delivery and there is a need for its rational use; although there have been major improvements in the pharmaceutical sector in the recent past, inappropriate medication use is considered a major threat to patients' health. Therefore, the pattern of medication use should be monitored routinely. The aim of this study was to investigate the population-based prevalence of polypharmacy and the patterns of medication use in southwestern Iran. We also investigated correlates between polypharmacy and patterns of medication use.Methods: Data from the Khuzestan Comprehensive Health Study (KCHS) which consists information of 30 506 with age range to 20 to 65 years were used. Crude and age-standardized prevalence of polypharmacy and their 95% confidence intervals were estimated for different subpopulations. Multivariable Poisson regression modeling was applied, and adjusted prevalence ratios and their 95% confidence intervals were estimated. The Anatomical Therapeutic Chemical classification system (first and second levels) was used for drug classification in different groups based on age, gender, and socioeconomic status.Erfan Taherifard and Zahra Mohammadi are co-first authors.

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Potentially inappropriate medication use in elderly patients

Abstract: PIM use was common (23.5%) among the elderly patients during their stay in medicine wards in two tertiary care hospitals. Measures targeted only at BC medications may do little to change the risk of ADRs in elderly.

Cited by 56 publications

References 26 publications

Potentially Inappropriate Medication Use Among Older Hospitalized Patients in a Brazilian General Hospital

Potentially Inappropriate Medication Use Among Older Hospitalized Patients in a Brazilian General Hospital

Utilization of potentially inappropriate medications in elderly patients in a tertiary care teaching hospital in India

Population‐based prevalence of polypharmacy and patterns of medication use in southwestern Iran: A cross‐sectional study

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