Potentially zoonotic gastrointestinal nematodes co‐infecting free ranging non‐human primates in Kenyan urban centres

Mbuthia, Peris; Murungi, Edwin; Owino, Vincent; Akinyi, Mercy; Eastwood, Gillian; Nyamota, Richard; Lekolool, Isaac; Jeneby, Maamun

doi:10.1002/vms3.424

Cited by 4 publications

(4 citation statements)

References 40 publications

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“…stephanostomum reported from apes and monkeys in Kenya (Mbuthia et al, 2021), Uganda (Cibot et al, 2015;Ghai et al, 2014;Krief et al, 2010;Ota et al, 2015), Gabon (Makouloutou et al, 2014;Sirima et al, 2021), Cameroon (Hamad et al, 2014;Ilík et al, 2023;Sirima et al, 2021), Democratic Republic of the Congo (Medkour et al, 2021;Narat et al, 2015) and Tanzania (Gasser et al, 1999;Terio et al, 2018). The sequences from the eastern chimpanzees in Gombe (Terio et al, 2018) are the only other published O.…”

Section: Comparison With Oesophagostomum Sequences From Other Field S...mentioning

confidence: 96%

Oesophagostomum stephanostomum causing parasitic granulomas in wild chimpanzees (Pan troglodytes verus) of Taï National Park, Côte d'Ivoire

Jaffe,

Metzger,

Mätz‐Rensing

et al. 2024

American J Primatol

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Nematodes belonging to the genus Oesophagostomum frequently infect wild chimpanzees (Pan troglodytes) across widely separated field sites. Nodular lesions (granulomas) containing Oesophagostomum are commonly seen in the abdomen of infected chimpanzees post‐mortem. At Taï National Park, Côte d'Ivoire, previous studies have identified larvae of a variety of Oesophagostomum spp. in wild chimpanzee stool, based on sequencing of larval DNA, and nodular lesions associated with Oesophagostomum, identified morphologically to the genus level but not sequenced. Here we present three recent cases of parasitic granulomas found post‐mortem in chimpanzees at Taï. We complement descriptions of gross pathology, histopathology and parasitology with PCR and sequencing of DNA isolated from the parasitic nodules and from adult worms found inside the nodules. In all three cases, we identify Oesophagostomum stephanostomum as the causative agent. The sequences from this study were identical to the only other published sequences from nodules in nonhuman primates—those from the wild chimpanzees of Gombe, Tanzania.

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Section: Comparison With Oesophagostomum Sequences From Other Field S...mentioning

confidence: 96%

Oesophagostomum stephanostomum causing parasitic granulomas in wild chimpanzees (Pan troglodytes verus) of Taï National Park, Côte d'Ivoire

Jaffe,

Metzger,

Mätz‐Rensing

et al. 2024

American J Primatol

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“…(Mul et al, 2007). Menurut Kurniawati et al (2020), nematoda gastrointestinal tersebut berpotensi menular ke manusia melalui interaksi yang cukup dekat antara manusia dan monyet ekor panjang (Mbuthia et al, 2021). Satwa primata dewasa yang terinfeksi dapat mengalami penurunan produksi, sedangkan pada satwa muda dapat mengakibatkan pertumbuhan terhambat, nafsu makan menurun, anemia, dan diare (Bellantari et al, 2021).…”

Section: Pendahuluanunclassified

Kejadian nematodosis gastrointestinal pada monyet ekor panjang (Macaca fascicularis) di Pusat Studi Satwa Primata LPPM IPB

2023

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Monyet ekor panjang (Macaca fascicularis) sering digunakan sebagai hewan model dalam penelitian biomedis. Nematodosis umum ditemukan pada kelompok primata yang bukan manusia atau non-human primate. Nematodosis gastrointestinal dapat memengaruhi hasil penelitian atau berpotensi sebagai sumber penularan ke manusia (zoonosis). Penelitian bertujuan melakukan identifikasi tipe, menghitung tingkat kejadian dan derajat infeksi kecacingan nematoda gastrointestinal pada monyet ekor panjang di kandang penangkaran Pusat Studi Satwa Primata, Lembaga Penelitian dan Pengabdian kepada Masyarakat IPB (PSSP LPPM IPB) serta membandingkan dua metode pemeriksaan kuantitatif McMaster dan Kato-Katz. Sampel feses dari 24 ekor monyet ekor panjang diperiksa menggunakan metode flotasi sederhana, yaitu McMaster dan Kato-Katz. Sembilan (37,5%) dari 24 sampel terinfeksi oleh trichurid (20,8%), ascarid (12,5%), dan strongylid (4,2%), masing-masing dengan rataan derajat infeksi 833,3 ± 923,8; 32 ± 27,7; dan 12 ± 17 telur tiap gram tinja (TTGT). Tingkat infeksi namatodosis pada monyet ekor panjang berdasarkan kelompok umur dan jenis kelamin berturut-turut adalah pada bayi 50%, anak 50%, remaja 16,7%, dewasa 33,3%, jantan 33,3%, dan betina 41,7%. Tingkat kejadian dan derajat infeksi nematodosis gastrointestinal pada monyet ekor panjang menunjukkan kategori sedang hingga rendah. Hasil ini dapat dijadikan pertimbangan dalam manajemen pemeliharaan, penelitian biomedis, dan mitigasi risiko potensi penularan ke manusia.

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“…Reverse transcriptase polymerase chain reaction (RT-PCR) has been applied in screening viruses such as H1N1, H3N2 in uenza viruses and coronaviruses in NHPs present in Kenya (Bunuma et al, 2018;Gambo, 2018). More recently, High resolution melting PCR (PCR_HRM) has been introduced and used for detection of multiple parasite species in NHPs that are within the same genus (Mbuthia Peris et al, 2020;Nyamota et al, 2020). This approach cuts out the need for sequencing and hence reduces diagnostic costs.…”

Section: Diagnostic Techniques Employed For Kenyan Nhp Surveillancementioning

confidence: 99%

Surveillance of emerging infectious diseases in wild non-human primates in Kenya: Successes and challenges

Akinyi

Stanislaus

Mbuthia

et al. 2021

Preprint

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Emerging infectious diseases (EIDs) originating from wildlife present a significant threat to global health, security, and economic growth, thus combatting their emergence is a public health priority. Humans and non-human primates (NHPs) exhibit a high degree of overlap in their genetic and physiological similarities, hence making them susceptible to majority of pathogens that can cross the primate species boundaries. However, efforts to understand the potential infectious disease-causing pathogens harbored by wild primate populations has lagged and is yet to be fully explored. Disease surveillance in wildlife to identify probable infectious disease outbreaks has remained a challenge especially in developing countries due to logistical and financial constrains associated with both periodic and longitudinal sample collection. Such loopholes have hampered the preparedness to handle the emerging infectious diseases whenever they arise. In this review we focus on successes, challenges, and proposed solutions for EID surveillance in non-human primate populations in Kenya. We discuss,1) mechanisms of cross species transmission of EIDs, 2) the role of NHPS in EID transmission, 3) results from past NHP pathogen surveillance projects in Kenya and 4) challenges and proposed solutions for NHP-EID surveillance. Finally, we propose that more studies need to include investigations into understanding how cross species transmission occurs in diverse NHP populations and how this impacts one health.

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Potentially zoonotic gastrointestinal nematodes co‐infecting free ranging non‐human primates in Kenyan urban centres

Cited by 4 publications

References 40 publications

Oesophagostomum stephanostomum causing parasitic granulomas in wild chimpanzees (Pan troglodytes verus) of Taï National Park, Côte d'Ivoire

Oesophagostomum stephanostomum causing parasitic granulomas in wild chimpanzees (Pan troglodytes verus) of Taï National Park, Côte d'Ivoire

Kejadian nematodosis gastrointestinal pada monyet ekor panjang (Macaca fascicularis) di Pusat Studi Satwa Primata LPPM IPB

Surveillance of emerging infectious diseases in wild non-human primates in Kenya: Successes and challenges

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Potentially zoonotic gastrointestinal nematodes co‐infecting free ranging non‐human primates in Kenyan urban centres

Cited by 4 publications

References 40 publications

Oesophagostomum stephanostomum causing parasitic granulomas in wild chimpanzees (Pan troglodytes verus) of Taï National Park, Côte d'Ivoire

Oesophagostomum stephanostomum causing parasitic granulomas in wild chimpanzees (Pan troglodytes verus) of Taï National Park, Côte d'Ivoire

Kejadian nematodosis gastrointestinal pada monyet ekor panjang (Macaca fascicularis) di Pusat Studi Satwa Primata LPPM IPB

﻿Surveillance of emerging infectious diseases in wild non-human primates in Kenya: Successes and challenges

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Surveillance of emerging infectious diseases in wild non-human primates in Kenya: Successes and challenges