A submerged anaerobic membrane bioreactor (AnMBR) demonstration plant with two commercial hollow-fibre ultrafiltration systems (PURON ® , KochMembrane Systems, PUR-PSH31) was designed and operated for urban wastewater treatment. An instrumentation, control, and automation (ICA) system was designed and implemented for proper process performance. Several singleinput-single-output (SISO) feedback control loops based on conventional on-off and PID algorithms were implemented to control the following operating variables: flow-rates (influent, permeate, sludge recycling and wasting, and recycled biogas through both reactor and membrane tanks), sludge wasting volume, temperature, transmembrane pressure, and gas sparging. The proposed ICA for AnMBRs for urban wastewater treatment enables the optimisation of this new technology to be achieved with a high level of process robustness towards disturbances.