Potentials of Biowaste Carbohydrates in Gut Health Enhancement

El-Hindawy, Marwa

doi:10.1007/978-3-030-84436-3_2

Cited by 2 publications

(2 citation statements)

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“…The pathogenesis of hyperlipidemia may be closely related to intestinal flora since an imbalance of intestinal microecological flora is often found in hyperlipidemia patients, and the imbalance can conversely aggravate lipid metabolism disorder, leading to a vicious circle (Lv et al, 2018 ). It has been found that polysaccharides can improve the integrity of intestinal barrier function, reduce the intestinal mucosal damage, promote the growth and reproduction of beneficial bacteria related to intestinal hyperlipidemia, and inhibit the growth and reproduction of harmful bacteria to regulate and maintain their normal physiological activities by shaping the intestinal flora (Du et al, 2013 ; El Kaoutari et al, 2013 ; El‐Hindawy, 2022 ). The products from polysaccharides degraded by intestinal flora, including lactic acid, acetic acid, propionic acid, and butyric acid, can regulate the pH and microbial diversity in intestines, and provide energy for the body, playing a key role in the protection of the normal peristalsis and barrier of intestines (El‐Hindawy, 2022 ; Okeke et al, 2014 ; Uebanso et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

“…It has been found that polysaccharides can improve the integrity of intestinal barrier function, reduce the intestinal mucosal damage, promote the growth and reproduction of beneficial bacteria related to intestinal hyperlipidemia, and inhibit the growth and reproduction of harmful bacteria to regulate and maintain their normal physiological activities by shaping the intestinal flora (Du et al, 2013 ; El Kaoutari et al, 2013 ; El‐Hindawy, 2022 ). The products from polysaccharides degraded by intestinal flora, including lactic acid, acetic acid, propionic acid, and butyric acid, can regulate the pH and microbial diversity in intestines, and provide energy for the body, playing a key role in the protection of the normal peristalsis and barrier of intestines (El‐Hindawy, 2022 ; Okeke et al, 2014 ; Uebanso et al, 2017 ). Further study on whether IOP can exert its hypolipidemic activity by regulating intestinal flora is needed.…”

Section: Introductionmentioning

confidence: 99%

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Study on the hypolipidemic effect of Inonotus obliquus polysaccharide in hyperlipidemia rats based on the regulation of intestinal flora

Lin

Guo

et al. 2022

Food Science & Nutrition

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The purpose of this study was to observe the effect of Inonotus obliquus polysaccharide (IOP) on blood lipids and its regulation on the intestinal flora in hyperlipidemia rats, and explore the modern biological connotation of IOP in reducing blood lipids. In this study, we obtained the crude IOP by the water extraction and alcohol precipitation method, and then classified it by DEAE ion‐exchange chromatography to obtain the acidic I. obliquus polysaccharide (IOP‐A). After the administration of the IOP‐A, the serum TC, TG, and LDL‐C levels were significantly lower, while the serum HDL‐C levels were significantly higher. The expression of CYP7A1 protein was considerably increased, whereas the expression of SREBP‐1C protein was considerably decreased in the rat hepatic tissue. In addition, the IOP‐A could significantly alleviate the hepatocyte fatty degeneration in the liver lobule of rats. We believe that the IOP‐A can affect the composition of intestinal flora by reducing the relative abundance of Firmicutes and increasing the relative abundance of Bacteroidetes. These findings indicated that the IOP‐A can regulate the dyslipidemia of hyperlipidemia rats, and its mechanism may be through regulating the CYP7A1 and SREBP‐1C expression in the metabolism of lipids, and correcting the imbalance of intestinal flora structure caused by a high‐fat diet.

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