Potentiation of Antiepileptic Activity of Phenytoin Using Beta Carotene Against Maximal Electroshock Induced Convulsions in Mice

Abstract

Phenytoin is the mostly used drug for the seizures. However question regarding safety and efficacy of this drug make it particularly compelling to identify adjunct therapy that could boost therapeutic benefit. Study found that one adjunct therapy is beta carotene. The main aim of present study was to evaluate potentiation of antiepileptic activity of Phenytoin by beta carotene in mice against maximal electroshock induced (MES) induced convulsions. In these methods all the animals were divided into sixteen groups & each group consists of six animals. Shock 50mA for 0.2 sec was applied for all groups of mice. Testing drugs doses were randomised within groups of animal in such way that each group was required during a given test series. The results revealed that beta carotene significantly potentiated efficacy of phenytoin but did not exert antiepileptic effect on its own. Alone beta carotene at the dose of 20mg/kg p.o. significantly reduced elevated MDA level in serum. Concurrent administration of phenytoin and beta carotene on serum MDA activity was not differed with alone beta carotene at the dose of 20mg/kg. It is concluded that beta carotene potentiates the antiepileptic activity of phenytoin.

Evaluation of Alpha-Amylase Inhibitory, Antioxidant, and Antimicrobial Potential and Phytochemical Contents of Polygonum hydropiper L.

“…The therapeutic application of β-carotene showed a strong association with a lower risk of lung cancer [33]. β-Carotene along with phenytoin has great antiepileptic activity and can be used as a therapeutic agent in epilepsy management [34]. Tannins have been reported as anticancer and anti-inflammatory agents and can be used for ulcerated tissues [35][36][37].…”

Cytotoxic Potential and Molecular Pathway Analysis of Silver Nanoparticles in Human Colon Cancer Cells HCT116

“…Low concentrations of poly ( N -vinyl-2-pyrrolidone)-coated AgNPs inhibited the viability of acute myeloid leukemia cells and the viability of K562 cells in a dose-dependent manner after entering the cells via endocytic pathway endosomes [13]. Importantly, AgNPs were shown to exert anti-cancer effects and exhibited cytotoxicity via different mechanisms on cancer cells, such as by inducing cellular apoptosis through mitochondria-dependent and mitochondria-independent pathways against various types of cancer cells, including human breast cancer cells (MCF-7, MDA-MB-231), lung cancer cells (A549), liver (HepG2), and skin and oral carcinoma cell lines (HT144), via the leakage of lactate dehydrogenase, reactive oxygen species (ROS) generation, and the impairment of mitochondrial dysfunction [14,15,16,17,18,19]. However, the anti-cancer activity of AgNPs depends on various factors such as their size, shape, and surface coatings, as well as the surface charge, the type of cells, and the type of reducing agents used to synthesize the AgNPs.…”